PDF(Pubmed)
Abstract：
UNASSIGNED: To investigate the association of altered serum ferritin during pregnancy with chorioamnionitis and neonatal sepsis.
UNASSIGNED: This retrospective cohort study included 78,521 pregnant women who attended antenatal check-ups at maternal and child health centers in Fujian Province, China. Study lasted from January 2014 to January 2019. A total of 59,812 pregnant women were followed up. Patients with suspected infection before the delivery were selected and divided into the chorioamnionitis and non-chorioamnionitis groups according to placental pathology. Differences in late and early pregnancy serum ferritin between the two groups were compared. Multiple logistics regression was used to adjust for confounding factors and to analyze the association between serum ferritin changes and pregnancy outcomes. Importance of altered serum ferritin during pregnancy was assessed by receiver operating characteristic (ROC) curve and net reclassification index (NRI).
UNASSIGNED: Clinical records of 8506 pregnant women were included in the study. there were 1010 (11.9%) cases of confirmed chorioamnionitis and 263 (3.1%) cases of neonatal sepsis. There was a significant difference in maternal serum ferritin changes between the groups with and without chorioamnionitis. No significant difference was detected in cases with or without neonatal sepsis. Multiple logistic regressions, corrected for confounding factors yielded similar conclusions. Maternal serum ferritin difference NRI 12.18% (p = 0.00014) was similar to the ROC results in predicting the occurrence of chorioamnionitis.
UNASSIGNED: Differential serum ferritin during pregnancy may predict chorioamnionitis but does not correlate well with neonatal sepsis.
UNASSIGNED: This retrospective cohort study included 78,521 pregnant women who attended antenatal check-ups at maternal and child health centers in Fujian Province, China. Study lasted from January 2014 to January 2019. A total of 59,812 pregnant women were followed up. Patients with suspected infection before the delivery were selected and divided into the chorioamnionitis and non-chorioamnionitis groups according to placental pathology. Differences in late and early pregnancy serum ferritin between the two groups were compared. Multiple logistics regression was used to adjust for confounding factors and to analyze the association between serum ferritin changes and pregnancy outcomes. Importance of altered serum ferritin during pregnancy was assessed by receiver operating characteristic (ROC) curve and net reclassification index (NRI).
UNASSIGNED: Clinical records of 8506 pregnant women were included in the study. there were 1010 (11.9%) cases of confirmed chorioamnionitis and 263 (3.1%) cases of neonatal sepsis. There was a significant difference in maternal serum ferritin changes between the groups with and without chorioamnionitis. No significant difference was detected in cases with or without neonatal sepsis. Multiple logistic regressions, corrected for confounding factors yielded similar conclusions. Maternal serum ferritin difference NRI 12.18% (p = 0.00014) was similar to the ROC results in predicting the occurrence of chorioamnionitis.
UNASSIGNED: Differential serum ferritin during pregnancy may predict chorioamnionitis but does not correlate well with neonatal sepsis.
摘要：
■探讨妊娠期血清铁蛋白改变与绒毛膜羊膜炎和新生儿败血症的关系。
■这项回顾性队列研究包括在福建省妇幼保健中心进行产前检查的78,521名孕妇,中国。研究从2014年1月持续到2019年1月。共随访了59,812名孕妇。选择分娩前疑似感染的患者,根据胎盘病理分为绒毛膜羊膜炎组和非绒毛膜羊膜炎组。比较两组孕晚期和孕早期血清铁蛋白的差异。采用多元物流回归对混杂因素进行校正，并分析血清铁蛋白变化与妊娠结局的相关性。通过受试者工作特征（ROC）曲线和净分类指数（NRI）评估妊娠期血清铁蛋白改变的重要性。
■8506名孕妇的临床记录被纳入研究。有1010例（11.9％）确诊的绒毛膜羊膜炎和263例（3.1％）新生儿败血症。有和没有绒毛膜羊膜炎的组之间的母体血清铁蛋白变化有显着差异。在有或没有新生儿败血症的病例中没有发现显着差异。多元逻辑回归，对混杂因素进行校正后得出类似的结论。母体血清铁蛋白差异NRI12.18％（p=0.00014）与预测绒毛膜羊膜炎发生的ROC结果相似。
妊娠期血清铁蛋白差异可预测绒毛膜羊膜炎，但与新生儿败血症的相关性不大。
■这项回顾性队列研究包括在福建省妇幼保健中心进行产前检查的78,521名孕妇,中国。研究从2014年1月持续到2019年1月。共随访了59,812名孕妇。选择分娩前疑似感染的患者,根据胎盘病理分为绒毛膜羊膜炎组和非绒毛膜羊膜炎组。比较两组孕晚期和孕早期血清铁蛋白的差异。采用多元物流回归对混杂因素进行校正，并分析血清铁蛋白变化与妊娠结局的相关性。通过受试者工作特征（ROC）曲线和净分类指数（NRI）评估妊娠期血清铁蛋白改变的重要性。
■8506名孕妇的临床记录被纳入研究。有1010例（11.9％）确诊的绒毛膜羊膜炎和263例（3.1％）新生儿败血症。有和没有绒毛膜羊膜炎的组之间的母体血清铁蛋白变化有显着差异。在有或没有新生儿败血症的病例中没有发现显着差异。多元逻辑回归，对混杂因素进行校正后得出类似的结论。母体血清铁蛋白差异NRI12.18％（p=0.00014）与预测绒毛膜羊膜炎发生的ROC结果相似。
妊娠期血清铁蛋白差异可预测绒毛膜羊膜炎，但与新生儿败血症的相关性不大。
