本横断面调查旨在调查巴基斯坦北部边境地区口蹄疫的分布和危险因素。从小反刍动物(239)和大反刍动物(146)中汇编了约385份血清样品,并使用3ABC-Mab-bELISA进行了测试。记录了67.0%的总体明显血清阳性率。在斯瓦特报告的最高血清阳性率为81.1%,其次是Mohmand的76.6%,吉尔吉特72.7%,上拉65.6%,Bajaur的63.4%,Chitral地区为46.6%,开伯尔地区最低为46.5%。51.5%的血清阳性率的统计学差异,71.8%,58.3%,在绵羊中记录了74.4%,山羊,牛,还有水牛,分别。从调查的不同风险因素来看,年龄,性别,动物的种类,季节,群/群大小,耕作方法,爆发地点,发现游牧动物运动与口蹄疫的血清阳性率显着相关(p<0.05)。结论是,适当的流行病学研究,小反刍动物基于风险的口蹄疫监测,疫苗接种策略,跨界动物转移的控制措施,合作,需要在研究地区实施意识计划,以调查大型和小型反刍动物中新传播的病毒株以及广泛血清流行率的相关因素,以计划适当的控制政策来约束该地区口蹄疫的后果。
The present cross-sectional survey was carried out to investigate the distribution and risk factors of FMD in Pakistan\'s northern border regions. About 385 serum samples were compiled from small ruminants (239) and large ruminants (146) and tested using 3ABC-Mab-bELISA. An overall apparent seroprevalence of 67.0% was documented. The highest seroprevalence of 81.1% was reported in the Swat, followed by 76.6% in Mohmand, 72.7% in Gilgit, 65.6% in Shangla, 63.4% in Bajaur, 46.6% in Chitral and lowest 46.5% in Khyber region. Statistically significant variations in seroprevalence of 51.5%, 71.8%, 58.3%, and 74.4% were recorded in sheep, goats, cattle, and buffaloes, respectively. From the different risk factors investigated, age, sex, species of animal, seasons, flock/herd size, farming methods, outbreak location, and nomadic animal movement were found to be significantly associated (p < 0.05) with the seroprevalence of FMD. It was concluded that proper epidemiological study, risk-based FMD surveillance in small ruminants, vaccination strategy, control measures for transboundary animal movement, collaborations, and awareness programs need to be practiced in the study regions to investigate the newly circulating virus strains in large and small ruminants and associated factors for the wide seroprevalence to plan proper control policies to bound the consequence of FMD in the region.