PDF(Pubmed)
Abstract：
Perceptions of the complete eradication of vaccine-preventable diseases such as measles, mumps, and rubella (MMR) may foster complacency and compromise vaccination efforts. Decreased measles vaccination rates during the COVID-19 pandemic have heightened the risk of outbreaks, even in adequately vaccinated populations. To address this, we have aligned with ECDC recommendations, leveraging previous cross-border sero-epidemiological assessments between Pécs, Hungary, and Osijek, Croatia, to identify latent risk groups and uncover potential parallels between our nations. Testing 2680 Hungarian and 1764 Croatian serum samples for anti-MMR IgG via ELISAs revealed anti-measles seropositivity ratios below expectations in Croatian cohorts aged ~20-30 (75.7%), ~30-40 (77.5%) and ~40-50 years (73.3%). Similarly, Hungarian samples also showed suboptimal seropositivity ratios in the ~30-40 (80.9%) and ~40-50 (87.3%) age groups. Considering mumps- and rubella-associated seropositivity trends, in both examined populations, individuals aged ~30-50 years exhibited the highest vulnerability. Additionally, we noted congruent seropositivity trends across both countries, despite distinct immunization and epidemiological contexts. Therefore, we propose expanding research to encompass the intricate dynamics of vaccination, including waning long-term immunity. This understanding could facilitate targeted interventions and bolster public awareness. Our findings underscore persistent challenges in attaining robust immunity against measles despite vaccination endeavors.
摘要：
对完全根除麻疹等疫苗可预防疾病的认识,腮腺炎,和风疹（MMR）可能会助长自满情绪并损害疫苗接种工作。COVID-19大流行期间麻疹疫苗接种率下降增加了疫情爆发的风险，即使在充分接种疫苗的人群中。为了解决这个问题，我们与ECDC的建议保持一致，利用Pécs之间先前的跨境血清流行病学评估，匈牙利,还有奥西耶克,克罗地亚,确定潜在的风险群体，并发现我们国家之间的潜在相似之处。通过ELISA对2680名匈牙利和1764名克罗地亚血清样本进行抗MMRIgG检测，结果显示，在20-30岁的克罗地亚人群中，抗麻疹血清阳性率低于预期（75.7％），~30-40岁（77.5%）和~40-50岁（73.3%）。同样，匈牙利样本在〜30-40（80.9％）和〜40-50（87.3％）年龄组中也显示出次优的血清阳性率。考虑到腮腺炎和风疹相关的血清阳性趋势，在两个被检查的人群中，30-50岁的个体表现出最高的脆弱性。此外,我们注意到两国的血清阳性趋势一致，尽管有不同的免疫接种和流行病学背景。因此,我们建议扩大研究范围，以涵盖疫苗接种的复杂动态，包括长期免疫力下降.这种理解可以促进有针对性的干预措施并提高公众意识。我们的发现强调了尽管进行了疫苗接种，但在获得针对麻疹的强大免疫力方面仍存在持续的挑战。
