radius

半径
  • 文章类型: Journal Article
    影响桡骨远端的巨细胞瘤被认为更具侵袭性,与其他地方的同行相比。虽然人们提倡切除作为一种选择,但复发率较低,据报道,刮宫导致了优越的功能结果。这项回顾性研究旨在评估通过扩大病灶内刮治(EIC)或切除和尺骨放射疗法(RRU)进行GCT桡骨远端治疗的患者的功能和肿瘤学结果。关于局部复发率和功能。从2011年到2021年,由一名外科医生手术治疗桡骨远端巨细胞瘤的24例患者被纳入研究。人口统计,临床放射学,并记录和分析手术细节,功能和肿瘤结果也是如此。在中位数(IQR)6.3年的随访(范围2年至15.9年),刮治的复发率高于切除术,但无统计学意义(35.7%vs20%,p>0.05)。患者在其他地方管理,然后提交给我们复发有较高的局部复发率(66.6%,p=0.01)。平均复发时间为14个月(范围2-24个月)。关于最后的后续行动,刮宫组患者在握力和活动范围方面有较好的功能结局.平均改良梅奥腕部评分和MSTS评分分别为78.2和25.63,EIC组分别为69.6和25.75,用于RRU组。与尺骨放射切除和关节固定术相比,扩大病灶内刮治可使手腕移动和疾病控制更早地康复。
    Giant cell tumor affecting distal radius has been considered more aggressive, as compared to its counterparts in other locations. While resection has been advocated as the treatment of choice with lower rates of recurrence, curettage has reportedly led to superior functional outcomes. This retrospective study aimed to evaluate the functional and oncological outcomes of patients managed for GCT distal radius by either extended intralesional curettage (EIC) or resection and arthrodesis with radialisation of ulna (RRU), with respect to rates of local recurrence and function. Twenty-four patients operated for giant cell tumor of distal radius by a single surgeon from 2011 to 2021, were included in the study. The demographic, clinico-radiological, and surgical details were recorded and analyzed, as were the functional and oncological outcomes. At a median (IQR) follow-up of 6.3 years (range 2 years to 15.9 years), the rate of recurrence in curettage was found to be higher than that in resection but was not statistically significant (35.7% vs 20%, p > 0.05). Patients managed elsewhere and then presented to us for recurrence had a higher rate of local recurrence (66.6%, p = 0.01). Average time to recurrence was 14 months (range 2-24 months). On final follow-up, patients in curettage group had better functional outcomes in terms of grip strength and range of motion. Mean Modified Mayo Wrist score and MSTS score were 78.2 and 25.63, respectively, for EIC group and 69.6 and 25.75, respectively, for RRU group. Extended intralesional curettage resulted in an earlier rehabilitation with a mobile wrist and acceptable disease control when compared with resection and arthrodesis with radialisation of ulna.
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  • 文章类型: Journal Article
    目的:本研究调查了仅桡骨固定与桡骨和尺骨固定治疗前臂远端双骨骨折患儿的临床和功能结局。
    方法:来自两个中心的71例前臂远端双骨骨折患者(尺骨-是组30例,回顾性分析了尺骨组41例)接受闭合复位和经皮钉扎治疗的患者。操作持续时间,透视曝光次数,比较了两组患者的减少率和基于影像学评估的角度。在最后一次随访时比较了腕关节功能的评估,包括Gartland-Werley评分和Mayo腕关节评分。
    结果:尺骨-no组(6.11±1.56°;6.51±1.69°)在骨愈合后的尺骨角度明显大于尺骨-yes组(4.49±1.30°;5.05±2.18°)(p<0.05)。尺骨-是组之间的减少率没有发现显着差异(6.67%,2/30)和无尺骨组(4.88%,2/41)(p>0.05)。在最后的随访中,尺骨组Gartland-Werley评分(1.83±3.25,范围:0-16)与尺骨无差异(1.85±2.72,范围:0-11.5)(p>0.05)。尺骨-是组(92.60±6.20)和尺骨-无组(92.15±7.58)之间的MayoWrist评分差异无统计学意义(p>0.05)。
    结论:对于儿童前臂远端双骨骨折,与桡骨和尺骨的固定相比,仅桡骨的固定似乎是一种可行的方法,具有相同的临床结果。
    OBJECTIVE: This study investigated the clinical and functional outcomes of children with distal both-bone forearm fractures treated by fixation of the radius only compared to fixation of both the radius and ulna.
    METHODS: A total of 71 patients from two centres with distal both-bone forearm fractures (30 in the ulna-yes group, 41 in the ulna-no group) who underwent closed reduction and percutaneous pinning treatment were retrospectively analysed. Operation duration, number of fluoroscopic exposures, loss of reduction rate and angulation based on radiographic assessment were compared between the two groups. Evaluation of wrist function including Gartland-Werley Score and Mayo Wrist Score were compared at the last follow-up.
    RESULTS: Ulna angulation upon bone healing on the posteroanterior and the lateral plane of ulna-no group (6.11 ± 1.56°; 6.51 ± 1.69°) was significantly greater than that of ulna-yes group (4.49 ± 1.30°; 5.05 ± 2.18°) (p < 0.05). No significant difference was found in the loss of reduction rate between ulna-yes group (6.67%, 2/30) and the ulna-no group (4.88%, 2/41) (p > 0.05). At last follow-up, no significant difference was found between the Gartland-Werley Scores of the ulna-yes group (1.83 ± 3.25, range: 0-16) and ulna-no group (1.85 ± 2.72, range: 0-11.5) (p > 0.05). No significant difference was found between the Mayo Wrist Scores of the ulna-yes group (92.60 ± 6.20) and ulna-no group (92.15 ± 7.58) (p > 0.05).
    CONCLUSIONS: For distal both-bone forearm fractures in children, fixation of only the radius appears to be a viable method with equivalent clinical outcomes compared to fixation of both the radius and ulna.
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  • 文章类型: Journal Article
    背景:对于有症状的桡骨远端不愈合患者,常进行桡骨矫正截骨术。在3D计划的截骨术中,在使用两个尺骨调整左右长度差异后,未受影响的半径会反映在不均匀的半径上。这种方法假设畸形人群的尺骨长度差异与健康人群相似。本研究旨在分析桡骨远端畸形愈合人群尺骨长度的差异,并评估年龄的潜在影响。性别,或者在这个差异上有马伦尼翁一面。
    方法:我们使用双侧前臂CT扫描评估了65例桡骨远端畸形愈合的成年患者。构建了两个尺骨的3D模型,和长度差异沿标准化长度轴确定。将结果与没有半径畸形的两个种群进行比较。
    结果:平均绝对尺骨长度差为2.57mm(SD1.81),这与两个健康人群相当。这种差异并没有受到年龄的显著影响,性别,或者马伦联方面。
    结论:这项研究表明,在当前的3D计划过程中,使用尺骨长度差来校正径向长度差,在使用对侧桡骨作为桡骨畸形患者的矫正截骨术的模板之前,是安全的。
    BACKGROUND: A corrective radius osteotomy is often performed in patients with a symptomatic distal radius malunion. In 3D-planned osteotomies, the unaffected radius is mirrored over the malunited radius after adjusting for left-right length differences using both ulnae. This approach assumes that ulnar length differences in a malunion population are similar to those in a healthy population. This study was conducted to analyze the difference in ulnar length in a distal radius malunion population and to assess the potential influence of age, sex, or malunion side on this difference.
    METHODS: We evaluated 65 adult patients with distal radius malunion using bilateral forearm CT scans. 3D models of both ulnae were constructed, and length differences were determined along a standardized length axis. The results were compared to two populations without a radius malunion.
    RESULTS: The average absolute ulnar length difference was 2.57 mm (SD 1.81), which was comparable to the two healthy populations. This difference was not significantly affected by age, sex, or malunion side.
    CONCLUSIONS: This study demonstrated that using the ulnar length difference to correct for radial length difference in the current 3D planning process, before using the contralateral radius as a template for a corrective osteotomy in patients with radius malunion, is safe.
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  • 文章类型: Journal Article
    哈氏合金B2是一种高性能镍钼合金,已用于微反应器,泵,管道,和耐腐蚀设备。在上述应用部件中需要方孔。尽管在电火花加工(EDM)中消耗更多的电极磨损很容易产生方孔。此外,方孔与小电极磨损实现是一个具有挑战性的任务在热加工。因此,在这项工作中,电火花加工工艺参数对电极锥角的影响,电极半径,研究了HastelloyB2的电极磨损长度和切割时间。基于Taguchi的VišekriterijumskoKompromisnoRangiranje(VIKOR)方法用于找到最佳工艺参数,并与基于Taguchi的灰色关联分析(GRA)方法进行比较以进行验证。结果表明,电流和脉冲持续时间对电极磨损表面和边缘有很大影响。由于具有热扩散的不稳定火花,具有尖锐边缘和表面的方形电极在电极端部完全转变成半球形。此外,VIKOR方法提供了一种替代的多准则优化方法,该方法由于可比性而比灰色关联分析增强了过程性能,独特性,评估和预测。
    Hastelloy B2 is a high-performance nickel-molybdenum alloy and has been used in micro reactor, pump, pipe, and corrosion-resistant equipment. Square holes are required in the above application components. Although square holes are easily produced by spending more electrodes wear in Electrical Discharge Machining (EDM). Moreover, the square hole with small electrode wear achieved is a challenging task in thermal machining. Hence, in this work, the effects of EDM process parameters on electrode taper angle, electrode radius, electrode wear length and cutting time of Hastelloy B2 are studied. Taguchi based VišekriterijumskoKompromisnoRangiranje (VIKOR) method is used to find the optimum process parameters and compared with Taguchi based Grey Relational Analysis (GRA) method for validation. The results showed that current and pulse duration greatly affects the electrode wear out surface and edges. The square electrodes with sharp edges and surfaces are fully transformed into hemispherical shapes at electrode ends due to an unstable spark with diffusion of heat. Also, the VIKOR method provides an alternative multi-criteria optimization method that enhances the process performance over the grey relational analysis due to comparability, uniqueness, assessment and prediction.
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  • 文章类型: Journal Article
    背景:研究表明,内侧半月板后根撕裂(MMPRT)与骨的形态特征之间存在关联。然而,股骨远端骨形态与MMPRT的关系,特别是股骨内侧后髁,知之甚少。我们的研究旨在确定股骨内侧后髁的形态学特征与MMPRT之间的关联。
    方法:于2021年1月至2022年1月进行了回顾性病例对照研究。在根据纳入和排除标准进行筛选后,分析了两个匹配的组:MMPRT组和孤立的外侧半月板撕裂组。在X光片上测量髋-膝-踝角度(HKA)和Kellgren-Lawrence等级(KLG);胫骨内侧倾斜角(MTSA),胫骨平台内侧深度(MTPD),两组均在磁共振成像(MRI)上测量股骨内侧后髁(RMFPC)的半径。通过使用受试者工作特征(ROC)曲线分析计算曲线下面积(AUC)和预测MMPRT的最佳临界值。
    结果:最终分析共包括174例患者(87例MMPRT患者和87例对照)。在RMFPC中显示出显着差异(17.6±1.0与16.2±1.0,p<0.01)和MTSA(6.4±2.0vs.4.0±1.3,p<0.01),大于对照组。MTPD(1.8±0.6vs.2.9±0.7,p<0.01)和HKA(175.4±2.2vs.损伤组179.0±2.7,p<0.01)与对照组比较差异有显著性,均低于对照组。然而,在KLG上的MMPRT和对照组之间(2.3±0.6vs.2.2±0.6,p=0.209),差异无统计学意义。其中,通过ROC曲线分析,RMFPC截止值计算为16.8mm,敏感性和特异性均为81.61%。
    结论:这项研究表明,较大的RMFPC,MTSA,较小的MTPD,和HKA都与MMPRT有关,RMFPC≥16.8mm被认为是MMPRT的重要危险因素。
    BACKGROUND: Studies have shown an association between medial meniscus posterior root tears (MMPRT) and morphologic characteristics of the bone. However, the association between distal femoral bone morphology and MMPRT, particularly the medial femoral posterior condyle, is poorly understood. Our study aimed to determine the association between the morphologic characteristics of the medial posterior femoral condyle and MMPRT.
    METHODS: A retrospective case-control study was performed from January 2021 to January 2022. After screening based on the inclusion and exclusion criteria, two matched groups were analyzed: the MMPRT group and the isolated lateral meniscus tears group. The hip-knee-ankle angle (HKA) and Kellgren-Lawrence grade (KLG) were measured on radiographs; the medial tibial slope angle (MTSA), medial tibial plateau depth (MTPD), and radius of the medial femoral posterior condyle (RMFPC) were measured on magnetic resonance imaging (MRI) in both groups. The area under the curve (AUC) and the best cutoff value for predicting MMPRT were calculated by using receiver operating characteristic (ROC) curve analysis.
    RESULTS: The final analysis included a total of 174 patients (87 MMPRT patients and 87 controls). Significant differences were shown in the RMFPC (17.6 ± 1.0 vs. 16.2 ± 1.0, p < 0.01) and MTSA (6.4 ± 2.0 vs. 4.0 ± 1.3, p < 0.01), which were larger than those of the control group. The MTPD (1.8 ± 0.6 vs. 2.9 ± 0.7, p < 0.01) and HKA (175.4 ± 2.2 vs. 179.0 ± 2.7, p < 0.01) of the injury group were significantly different from the control group, and both were lower than the control group. However, between the MMPRT and control groups on the KLG (2.3 ± 0.6 vs. 2.2 ± 0.6, p = 0.209), there was no statistically significant difference. Among them, the RMFPC cutoff value was calculated to be 16.8 mm by ROC curve analysis, and the sensitivity and specificity were both 81.61%.
    CONCLUSIONS: This study demonstrated that larger RMFPC, MTSA, smaller MTPD, and HKA were all associated with MMPRT, and RMFPC ≥ 16.8 mm was considered as a significant risk factor for MMPRT.
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  • 文章类型: Journal Article
    背景:在人口老龄化的背景下,低冲击脆性骨折变得越来越普遍。然而,在早期发现低骨密度的情况下,可以降低骨折风险。在这项研究中,我们旨在证明IBEX骨骼健康(IBEXBH)可以从腕部X射线照片中的aBMD和T评分提供临床上有用的预测桡骨的远端(UD)和远端三分之一(DT)区域。
    方法:拥有261名参与者的单中心,非随机化,prospective,进行了研究,以比较a)IBEXBH,定量数字射线照相软件装置,至b)双能X射线吸收测定法(DXA)。共有257名参与者获得腕部数字射线照片(DR),前臂DXA对被纳入排除后的分析.
    结果:由GELunarDXA系统对UD区域产生的IBEXBH输出至radial面骨矿物质密度(aBMD)的调整后R2值为0.87(99%置信区间(CI)[0.84,0.89])。对于DT区域,IBEXBH输出到aBMD的调整的R2值为0.88(99%CI[0.85,0.90])。UD区域前臂T评分≤-2.5风险预测模型的受试者工作特征曲线下面积(AUC)为0.95(99%CI[0.93,0.98])。前臂T评分≤-2.5风险预测模型在DT区域的AUC为0.98(99%CI[0.97,0.99])。
    结论:从手腕的DR来看,IBEXBH提供了临床上有用的i)在半径上的两个感兴趣区域的aBMD估计,以及ii)在UD和DT区域的前臂T评分≤-2.5的风险预测模型。
    BACKGROUND: In an ageing population, low impact fragility fractures are becoming increasingly common. However, fracture risk can be reduced where low bone density can be identified at an early stage. In this study we aim to demonstrate that IBEX Bone Health (IBEX BH) can provide a clinically useful prediction from wrist radiographs of aBMD and T-score at the ultra-distal (UD) and distal-third (DT) regions of the radius.
    METHODS: A 261-participant single-centre, non-randomised, prospective, study was carried out to compare a) IBEX BH, a quantitative digital radiography software device, to b) Dual-energy X-ray Absorptiometry (DXA). A total of 257 participants with wrist digital radiograph (DR), forearm DXA pairs were included in the analysis after exclusions.
    RESULTS: The adjusted R2 value for IBEX BH outputs to the radial areal bone mineral density (aBMD) produced by a GE Lunar DXA system for the UD region is 0.87 (99% Confidence Interval (CI) [0.84, 0.89]). The adjusted R2 value for IBEX BH outputs to aBMD for the DT region is 0.88 (99% CI [0.85, 0.90]). The Area Under the Receiver Operating Characteristic curve (AUC) for the forearm T-score ≤  - 2.5 risk prediction model at the UD region is 0.95 (99% CI [0.93, 0.98]). The AUC for the forearm T-score ≤  - 2.5 risk prediction model at the DT region is 0.98 (99% CI [0.97, 0.99]).
    CONCLUSIONS: From a DR of the wrist, IBEX BH provides a clinically useful i) estimate of aBMD at the two regions of interest on the radius and ii) risk prediction model of forearm T-score ≤  - 2.5 at the UD and DT regions.
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  • 文章类型: Journal Article
    肘部计算机断层扫描(CT)扫描已广泛用于描述肘部形态。提高临床诊断的客观性和效率,一种自动识别方法,段,并重建肘关节骨是在这项研究中提出的。该方法包括三个步骤:最初,肱骨,尺骨,根据肘关节的解剖特征自动识别半径,并生成提示框。随后,肘部MedSAM是通过迁移学习获得的,通过整合提示框来准确分割CT图像。之后,执行孔填充和对象重新分类步骤以细化掩模。最后,三维(3D)重建是无缝地使用行进立方体算法进行。为了验证该方法的可靠性和准确性,这些图像与高级外科医生标记的面具进行了比较。对分割结果的定量评估显示,肱骨的平均交集联合(IoU)值为0.963、0.959和0.950,尺骨,和半径,分别。此外,重建的表面误差分别为1.127、1.523和2.062mm,分别。因此,自动肘部重建方法在临床诊断中显示出有希望的能力,术前计划,肘关节疾病的术中导航。
    Elbow computerized tomography (CT) scans have been widely applied for describing elbow morphology. To enhance the objectivity and efficiency of clinical diagnosis, an automatic method to recognize, segment, and reconstruct elbow joint bones is proposed in this study. The method involves three steps: initially, the humerus, ulna, and radius are automatically recognized based on the anatomical features of the elbow joint, and the prompt boxes are generated. Subsequently, elbow MedSAM is obtained through transfer learning, which accurately segments the CT images by integrating the prompt boxes. After that, hole-filling and object reclassification steps are executed to refine the mask. Finally, three-dimensional (3D) reconstruction is conducted seamlessly using the marching cube algorithm. To validate the reliability and accuracy of the method, the images were compared to the masks labeled by senior surgeons. Quantitative evaluation of segmentation results revealed median intersection over union (IoU) values of 0.963, 0.959, and 0.950 for the humerus, ulna, and radius, respectively. Additionally, the reconstructed surface errors were measured at 1.127, 1.523, and 2.062 mm, respectively. Consequently, the automatic elbow reconstruction method demonstrates promising capabilities in clinical diagnosis, preoperative planning, and intraoperative navigation for elbow joint diseases.
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  • 文章类型: Journal Article
    背景:Sauvé-Kapandji(S-K)方法是一种用于治疗桡骨远端尺骨关节(DRUJ)慢性畸形的外科手术。对于这种有用的治疗方法,尚未确定在生理体内条件下手术前后关节接触表面的变化。因此,本研究的目的是比较S-K方法治疗DRUJ疾病前后腕关节的关节接触面积。
    方法:对15例DRUJ骨关节炎和尺骨嵌塞综合征患者进行SK方法。我们计算了MayoWrist评分作为患者的临床发现,并创建了采用S-K方法的病例的三维骨模型,并使用定制软件计算了接触面积和接触面积中心的移位。
    结果:平均改良的Mayo腕关节评分从术前60.3显著提高至术后80.3(P<0.01)。舟骨与半径的接触面积从术前的112.6±37.0mm2显着增加到术后的127.5±27.8mm2(P=0.03)。术前与尺骨桡骨的肺接触面积为121.3±43.3mm2,术后为112.5±37.6mm2,但这种减少并不显著(P=0.38)。舟骨与月骨的接触面积比从术前的1.01±0.4显着增加到术后的1.20±0.3(P=0.02)。舟骨和月骨接触区域中心的术后平移被分解为尺骨和近端方向。舟骨接触区域的尺骨和近端平移距离分别为0.8±1.7mm和0.4±0.6mm,分别,月接触面积为1.1±1.7毫米和0.4±1.1毫米,分别。这项研究揭示了S-K方法前后手腕接触面积和接触面积中心的变化。
    结论:这些结果可以准确地指示DRUJ障碍患者使用S-K方法从术前到术后腕关节接触面积的变化。使用3DCT图像评估由于腕关节的骨表面建模而引起的接触面积的变化可能有助于考虑手术方法。
    BACKGROUND: The Sauvé-Kapandji (S-K) method is a surgical procedure performed for chronic deformities of the distal radial ulnar joint (DRUJ). Changes to the joint contact surface from pre- to postoperatively under physiological in vivo conditions have not yet been determined for this useful treatment. The aim of the present study was therefore to compare the articular contact area of the wrist joint between before and after the S-K method for DRUJ disorders.
    METHODS: The SK method was performed for 15 patients with DRUJ osteoarthritis and ulnar impaction syndrome. We calculated the Mayo Wrist Score as the patient\'s clinical findings and created 3-dimensional bone models of cases in which the S-K method was performed and calculated the contact area and shift in the center of the contact area using customized software.
    RESULTS: The Mean modified Mayo Wrist Score improved significantly from 60.3 preoperatively to 80.3 postoperatively (P < 0.01). Scaphoid contact area to the radius increased significantly from 112.6 ± 37.0 mm2 preoperatively to 127.5 ± 27.8 mm2 postoperatively (P = 0.03). Lunate contact area to radius-ulna was 121.3 ± 43.3 mm2 preoperatively and 112.5 ± 37.6 mm2 postoperatively, but this decrease was not significant (P = 0.38). Contact area ratio of scaphoid to lunate increased significantly from 1.01 ± 0.4 preoperatively to 1.20 ± 0.3 postoperatively (P = 0.02). Postoperative translations of the center of the scaphoid and lunate contact areas were decomposed into ulnar and proximal directions. Ulnar and proximal translation distances of the scaphoid contact area were 0.8 ± 1.7 mm and 0.4 ± 0.6 mm, respectively, and those of the lunate contact area were 1.1 ± 1.7 mm and 0.4 ± 1.1 mm, respectively. This study revealed changes in wrist contact area and center of the contact area before and after the S-K method.
    CONCLUSIONS: These results may accurately indicate changes in wrist joint contact area from pre- to postoperatively using the S-K method for patients with DRUJ disorder. Evaluation of changes in contact area due to bone surface modeling of the wrist joint using 3DCT images may be useful in considering surgical methods.
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  • 文章类型: Journal Article
    本研究旨在检查55岁及以上的髋部骨折患者桡骨远端骨折的发生率。骨质疏松相关骨折,尤其是髋部骨折,在骨密度降低的老年人中常见且严重。先前的研究表明髋部骨折与桡骨远端骨折之间存在关系。
    这项研究纳入了过去5年在阿赫塔尔医院就诊的55岁以上髋部骨折患者。在经历桡骨远端骨折之前有超过五年的髋部骨折病史的患者被排除在外。个人信息是从医疗记录中提取的,用SPSS软件对收集的数据进行统计学分析,如t检验和配对t检验。
    这项研究涉及1,745例髋部骨折患者和183例无骨折患者。患者平均年龄为75.8±10.4岁,大多数是女性(59.6%)。在髋部骨折中,59.6%,34.5%,5.9%为股骨转子间骨折,股骨颈骨折,和股骨转子下骨折,分别。总的来说,15.8%的髋部骨折患者也有桡骨远端骨折。两组患者的平均年龄和性别分布相似,没有显著差异。然而,髋部骨折组桡骨远端骨折的患病率明显较高,与对照组相比。
    发现55岁以上的桡骨远端骨折患者,尤其是女性,更容易发生髋部骨折.桡骨远端骨折对患者髋部骨折的发生有显著影响。因此,老年骨质疏松症患者应谨慎行事,避免发生可能导致跌倒和骨折的高危活动.
    UNASSIGNED: This study aimed to examine the incidence of distal radius fractures in patients aged 55 and above who had also experienced hip fractures. Osteoporosis-associated fractures, particularly hip fractures, are common and serious in older individuals with reduced bone density. Previous research has suggested a relationship between hip fractures and distal radius fractures.
    UNASSIGNED: The study included patients over 55 years old who had presented with hip fractures at Akhtar Hospital in the past five years. Patients with a history of hip fractures more than five years before experiencing the distal radius fracture were excluded. Personal information was extracted from medical records, and the collected data were analyzed in SPSS software using statistical methods, such as t-tests and paired t-tests.
    UNASSIGNED: This study involved 1,745 patients with hip fractures and 183 individuals without fractures. The average age of the patients was 75.8±10.4 years old, with the majority being female (59.6%). Among the hip fractures, 59.6%, 34.5%, and 5.9% were intertrochanteric fractures, neck of femur fractures, and subtrochanteric fractures, respectively. Overall, 15.8% of individuals with hip fractures also had distal radius fractures. The average age and gender distribution of the patients were similar in both groups, with no significant difference. However, the prevalence of distal radius fractures was significantly higher in the hip fracture group, compared to the control group.
    UNASSIGNED: It was found that individuals over the age of 55 with distal radius fractures, especially females, are more susceptible to hip fractures. Distal radius fractures have a significant impact on the occurrence of hip fractures in patients. Therefore, older individuals with osteoporosis should be cautious and avoid high-risk activities that could lead to falls and fractures.
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  • 文章类型: Journal Article
    2型糖尿病(T2DM)骨折风险增加的基础尚不清楚。在这个多民族,基于人群的研究(n=565),我们研究了骨微结构,使用第二代HRpQCT和个体小梁分割和矿化(ITS;ITM),伴有和不伴有骨折的T2DM女性(n=175)的小梁板/杆形态和矿化。与对照组相比,T2DM的所有部位的协变量校正aBMD均高3.0-6.5%(所有p<0.005)。通过HRpQCT,T2DM具有较高的协变量调整的小梁vBMD(5.3-6.4%)和数量(3.8-5.1%),并且在桡骨和胫骨的皮质面积更大。与对照组相比,仅T2DM胫骨的协变量调整皮质孔隙率高10.0%,但失效载荷没有差异。在患有T2DM的女性中,与没有骨折的患者(n=103)相比,成人无创伤骨折的患者(n=59)在所有部位的DXA校正aBMD降低5.2-8.5%.通过HRpQCT,骨折患者调整后的总vBMD较低,皮质面积较小(10.2-16.1%),较低的皮质厚度(10.5-15.8%)和较低的皮质vBMD分别与桡骨和胫骨的18.1%和17.2%的破坏负荷降低有关(均p<0.05);钢板体积和厚度分别降低5.7%和4.7%(p<0.05),而仅胫骨骨折组的棒体积分数高12.8%。钠葡萄糖协同转运蛋白2抑制剂使用者(SGLT2i;n=19),通过ITS倾向于具有较低的放射状杆组织矿物质密度(p=0.06)。GLP1激动剂使用者(n=19)在两个部位都有小梁缺陷,并且在胫骨远端有更高的皮质孔隙率和更大的孔。总之,T2DM与皮质孔隙度增加相关,而T2DM和骨折患者的皮质缺损更明显,骨小梁板更少,失效负荷更低。
    2型糖尿病(T2DM)患者骨折风险增加的原因尚不清楚。我们采用了多民族,基于人群的队列(n=565),使用先进的成像和分析技术研究女性T2DM(n=175)的骨骼结构。通过双能X线吸收法和高分辨率外周定量计算机断层扫描,T2DM参与者在桡骨和胫骨处倾向于具有更高的骨密度和更好的结构;与没有糖尿病的参与者相比,糖尿病参与者中只有皮质孔隙率更高(更差),但是骨强度没有差异。与T2DM患者相比,T2DM和骨折患者的皮质参数和骨强度均较低。总之,T2DM与皮质孔隙度增加相关,而T2DM和骨折患者的皮质缺损更明显,与较低的失效负荷相关。
    The basis for increased fracture risk in type 2 diabetes (T2DM) is not well understood. In this multi-ethnic, population-based study (n = 565), we investigated bone microstructure, trabecular plate/rod morphology, and mineralization in women with T2DM (n = 175) with and without fracture using a second-generation HRpQCT and individual trabecula segmentation and mineralization (ITS; ITM). Covariate-adjusted aBMD was 3.0%-6.5% higher at all sites (all p<.005) in T2DM vs controls. By HRpQCT, T2DM had higher covariate-adjusted trabecular vBMD (5.3%-6.4%) and number (3.8%-5.1%) and greater cortical area at the radius and tibia. Covariate-adjusted cortical porosity was 10.0% higher at the tibia only in T2DM vs controls, but failure load did not differ. Among women with T2DM, those with adult atraumatic fracture (n = 59) had 5.2%-8.5% lower adjusted aBMD at all sites by DXA compared with those without fracture (n = 103). By HRpQCT, those with fracture had lower adjusted total vBMD and smaller cortical area (10.2%-16.1%), lower cortical thickness (10.5-15.8%) and lower cortical vBMD associated with 18.1 and 17.2% lower failure load at the radius and tibia, respectively (all p<.05); plate volume and thickness were 5.7% and 4.7% lower, respectively, (p<.05) while rod volume fraction was 12.8% higher in the fracture group at the tibia only. Sodium glucose cotransporter 2 inhibitor users (SGLT2i; n = 19), tended to have lower radial rod tissue mineral density by ITS (p=.06). GLP1 agonist users (n = 19) had trabecular deficits at both sites and higher cortical porosity and larger pores at the distal tibia. In summary, T2DM is associated with increased cortical porosity while those with T2DM and fracture have more marked cortical deficits and fewer trabecular plates associated with lower failure load.
    Reasons for increased fracture risk in type 2 diabetes (T2DM) are not well-understood. We used a multi-ethnic, population-based cohort (n = 565), to study bone structure in women with T2DM (n = 175) using advanced imaging and analysis techniques. Participants with T2DM tended to have higher bone density and better structure by DXA and HRpQCT, respectively, at the radius and tibia; only cortical porosity was higher (worse) in participants with diabetes compared with those without diabetes but there was no difference in bone strength. Participants with T2DM and fracture had lower cortical parameters and bone strength compared with participants with T2DM without fracture at both sites. In summary, T2DM is associated with increased cortical porosity while those with T2DM and fracture have more marked cortical deficits associated with lower failure load.
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