{Reference Type}: Journal Article
{Title}: A comparison between IBEX bone health applied to digital radiographs and dual-energy X-ray absorptiometry at the distal-third and ultra-distal regions of the radius.
{Author}: Lopez B;Meertens R;Gundry M;Scott P;Crone MB;McWilliam R;
{Journal}: BMC Musculoskelet Disord
{Volume}: 25
{Issue}: 1
{Year}: 2024 Jul 24
{Factor}: 2.562
{DOI}: 10.1186/s12891-024-07670-0
{Abstract}: <B>BACKGROUND: </B>In an ageing population, low impact fragility fractures are becoming increasingly common. However, fracture risk can be reduced where low bone density can be identified at an early stage. In this study we aim to demonstrate that IBEX Bone Health (IBEX BH) can provide a clinically useful prediction from wrist radiographs of aBMD and T-score at the ultra-distal (UD) and distal-third (DT) regions of the radius.<BR><B>METHODS: </B>A 261-participant single-centre, non-randomised, prospective, study was carried out to compare a) IBEX BH, a quantitative digital radiography software device, to b) Dual-energy X-ray Absorptiometry (DXA). A total of 257 participants with wrist digital radiograph (DR), forearm DXA pairs were included in the analysis after exclusions.<BR><B>RESULTS: </B>The adjusted R2 value for IBEX BH outputs to the radial areal bone mineral density (aBMD) produced by a GE Lunar DXA system for the UD region is 0.87 (99% Confidence Interval (CI) [0.84, 0.89]). The adjusted R2 value for IBEX BH outputs to aBMD for the DT region is 0.88 (99% CI [0.85, 0.90]). The Area Under the Receiver Operating Characteristic curve (AUC) for the forearm T-score ≤  - 2.5 risk prediction model at the UD region is 0.95 (99% CI [0.93, 0.98]). The AUC for the forearm T-score ≤  - 2.5 risk prediction model at the DT region is 0.98 (99% CI [0.97, 0.99]).<BR><B>CONCLUSIONS: </B>From a DR of the wrist, IBEX BH provides a clinically useful i) estimate of aBMD at the two regions of interest on the radius and ii) risk prediction model of forearm T-score ≤  - 2.5 at the UD and DT regions.