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Abstract：
BACKGROUND: In an ageing population, low impact fragility fractures are becoming increasingly common. However, fracture risk can be reduced where low bone density can be identified at an early stage. In this study we aim to demonstrate that IBEX Bone Health (IBEX BH) can provide a clinically useful prediction from wrist radiographs of aBMD and T-score at the ultra-distal (UD) and distal-third (DT) regions of the radius.
METHODS: A 261-participant single-centre, non-randomised, prospective, study was carried out to compare a) IBEX BH, a quantitative digital radiography software device, to b) Dual-energy X-ray Absorptiometry (DXA). A total of 257 participants with wrist digital radiograph (DR), forearm DXA pairs were included in the analysis after exclusions.
RESULTS: The adjusted R2 value for IBEX BH outputs to the radial areal bone mineral density (aBMD) produced by a GE Lunar DXA system for the UD region is 0.87 (99% Confidence Interval (CI) [0.84, 0.89]). The adjusted R2 value for IBEX BH outputs to aBMD for the DT region is 0.88 (99% CI [0.85, 0.90]). The Area Under the Receiver Operating Characteristic curve (AUC) for the forearm T-score ≤ - 2.5 risk prediction model at the UD region is 0.95 (99% CI [0.93, 0.98]). The AUC for the forearm T-score ≤ - 2.5 risk prediction model at the DT region is 0.98 (99% CI [0.97, 0.99]).
CONCLUSIONS: From a DR of the wrist, IBEX BH provides a clinically useful i) estimate of aBMD at the two regions of interest on the radius and ii) risk prediction model of forearm T-score ≤ - 2.5 at the UD and DT regions.
METHODS: A 261-participant single-centre, non-randomised, prospective, study was carried out to compare a) IBEX BH, a quantitative digital radiography software device, to b) Dual-energy X-ray Absorptiometry (DXA). A total of 257 participants with wrist digital radiograph (DR), forearm DXA pairs were included in the analysis after exclusions.
RESULTS: The adjusted R2 value for IBEX BH outputs to the radial areal bone mineral density (aBMD) produced by a GE Lunar DXA system for the UD region is 0.87 (99% Confidence Interval (CI) [0.84, 0.89]). The adjusted R2 value for IBEX BH outputs to aBMD for the DT region is 0.88 (99% CI [0.85, 0.90]). The Area Under the Receiver Operating Characteristic curve (AUC) for the forearm T-score ≤ - 2.5 risk prediction model at the UD region is 0.95 (99% CI [0.93, 0.98]). The AUC for the forearm T-score ≤ - 2.5 risk prediction model at the DT region is 0.98 (99% CI [0.97, 0.99]).
CONCLUSIONS: From a DR of the wrist, IBEX BH provides a clinically useful i) estimate of aBMD at the two regions of interest on the radius and ii) risk prediction model of forearm T-score ≤ - 2.5 at the UD and DT regions.
摘要：
背景：在人口老龄化的背景下，低冲击脆性骨折变得越来越普遍。然而,在早期发现低骨密度的情况下，可以降低骨折风险。在这项研究中，我们旨在证明IBEX骨骼健康（IBEXBH）可以从腕部X射线照片中的aBMD和T评分提供临床上有用的预测桡骨的远端（UD）和远端三分之一（DT）区域。
方法：拥有261名参与者的单中心，非随机化，prospective,进行了研究，以比较a)IBEXBH，定量数字射线照相软件装置，至b)双能X射线吸收测定法(DXA)。共有257名参与者获得腕部数字射线照片（DR），前臂DXA对被纳入排除后的分析.
结果：由GELunarDXA系统对UD区域产生的IBEXBH输出至radial面骨矿物质密度（aBMD）的调整后R2值为0.87（99％置信区间（CI）[0.84，0.89]）。对于DT区域,IBEXBH输出到aBMD的调整的R2值为0.88(99%CI[0.85,0.90])。UD区域前臂T评分≤-2.5风险预测模型的受试者工作特征曲线下面积(AUC)为0.95(99%CI[0.93,0.98])。前臂T评分≤-2.5风险预测模型在DT区域的AUC为0.98(99%CI[0.97,0.99])。
结论：从手腕的DR来看，IBEXBH提供了临床上有用的i）在半径上的两个感兴趣区域的aBMD估计，以及ii）在UD和DT区域的前臂T评分≤-2.5的风险预测模型。
方法：拥有261名参与者的单中心，非随机化，prospective,进行了研究，以比较a)IBEXBH，定量数字射线照相软件装置，至b)双能X射线吸收测定法(DXA)。共有257名参与者获得腕部数字射线照片（DR），前臂DXA对被纳入排除后的分析.
结果：由GELunarDXA系统对UD区域产生的IBEXBH输出至radial面骨矿物质密度（aBMD）的调整后R2值为0.87（99％置信区间（CI）[0.84，0.89]）。对于DT区域,IBEXBH输出到aBMD的调整的R2值为0.88(99%CI[0.85,0.90])。UD区域前臂T评分≤-2.5风险预测模型的受试者工作特征曲线下面积(AUC)为0.95(99%CI[0.93,0.98])。前臂T评分≤-2.5风险预测模型在DT区域的AUC为0.98(99%CI[0.97,0.99])。
结论：从手腕的DR来看，IBEXBH提供了临床上有用的i）在半径上的两个感兴趣区域的aBMD估计，以及ii）在UD和DT区域的前臂T评分≤-2.5的风险预测模型。
