METHODS: A 261-participant single-centre, non-randomised, prospective, study was carried out to compare a) IBEX BH, a quantitative digital radiography software device, to b) Dual-energy X-ray Absorptiometry (DXA). A total of 257 participants with wrist digital radiograph (DR), forearm DXA pairs were included in the analysis after exclusions.
RESULTS: The adjusted R2 value for IBEX BH outputs to the radial areal bone mineral density (aBMD) produced by a GE Lunar DXA system for the UD region is 0.87 (99% Confidence Interval (CI) [0.84, 0.89]). The adjusted R2 value for IBEX BH outputs to aBMD for the DT region is 0.88 (99% CI [0.85, 0.90]). The Area Under the Receiver Operating Characteristic curve (AUC) for the forearm T-score ≤ - 2.5 risk prediction model at the UD region is 0.95 (99% CI [0.93, 0.98]). The AUC for the forearm T-score ≤ - 2.5 risk prediction model at the DT region is 0.98 (99% CI [0.97, 0.99]).
CONCLUSIONS: From a DR of the wrist, IBEX BH provides a clinically useful i) estimate of aBMD at the two regions of interest on the radius and ii) risk prediction model of forearm T-score ≤ - 2.5 at the UD and DT regions.
方法:拥有261名参与者的单中心,非随机化,prospective,进行了研究,以比较a)IBEXBH,定量数字射线照相软件装置,至b)双能X射线吸收测定法(DXA)。共有257名参与者获得腕部数字射线照片(DR),前臂DXA对被纳入排除后的分析.
结果:由GELunarDXA系统对UD区域产生的IBEXBH输出至radial面骨矿物质密度(aBMD)的调整后R2值为0.87(99%置信区间(CI)[0.84,0.89])。对于DT区域,IBEXBH输出到aBMD的调整的R2值为0.88(99%CI[0.85,0.90])。UD区域前臂T评分≤-2.5风险预测模型的受试者工作特征曲线下面积(AUC)为0.95(99%CI[0.93,0.98])。前臂T评分≤-2.5风险预测模型在DT区域的AUC为0.98(99%CI[0.97,0.99])。
结论:从手腕的DR来看,IBEXBH提供了临床上有用的i)在半径上的两个感兴趣区域的aBMD估计,以及ii)在UD和DT区域的前臂T评分≤-2.5的风险预测模型。