简介头颈部牙源性脓肿可导致严重的并发症,甚至导致死亡。这要求医疗保健专业人员对可用于诊断和治疗的所有炎症标志物有很好的了解。我们在日常医疗实践中使用的此类标记是白细胞(WBC),中性粒细胞(Neu),和C反应蛋白(CRP)。不知何故,背景是降钙素原(PCT),在这种化脓性感染中尚未详细研究。本研究的目的是调查和分析女性人群中头颈部牙源性化脓性感染的PCT,并将其与已经证实的炎症标志物如CRP进行比较。WBC,Neu。在文献中第一次,根据我们的知识,灵敏度,特异性,当使用PCT作为炎症的独立指标时,可以确定PCT的可预测性,并在患有头颈部牙源性脓肿的女性中确定其截止参考值。材料和方法这是一项前瞻性研究,其中CRP,WBC,Neu,对30例平均年龄为47岁(18-81岁)的头颈部牙源性脓肿妇女的PCT进行了检查和分析。作为对照组,我们纳入了30名平均年龄为48(18-80)岁的健康女性,在过去三个月中,没有记忆和物理证据表明存在任何感染。对于对照组也测量了四种标记。结果在临床的女性头颈部牙源性脓肿组中,CRP的平均值,WBC,Neu,与健康女性对照组相比,PCT和PCT显着升高(p<0.0001);CRP:95.46±76.41mg/lvs.0.63±0.37毫克/升,WBC:10.44±2.97x103/Lvs.6.5±1.49x103/L,Neu:7.92±2.93x103/Lvs.4.03±1.07x103/L,PCT:0.74±0.69ng/mlvs.0.14±0.08ng/ml。讨论PCT,以及CRP,WBC,Neu,在患有头颈部牙源性脓肿的女性中增加其血浆浓度,并且与之呈极正相关,与CRP高度相关,与WBC和Neu显著相关。此外,PCT与其他标志物相比具有许多优势;它开始更快地增加其血浆浓度,更快地达到其最大血浆浓度,感染消退后其浓度更快地正常化,并仅在细菌感染发生时增加其血液水平。结论PCT作为炎症标志物不仅与CRP呈正相关,WBC,还有Neu,凭借它比他们的优势,它似乎是诊断中最准确的指标,治疗,并在不久的将来随访牙源性头颈部脓肿;不仅在女性,而且在男性和儿童人群中。它的灵敏度,特异性,作为炎症的独立指标的可预测性是80%,76.7%,83%,分别,其临界值为0.225ng/ml,低于一般公认的0.5ng/ml。
Introduction
Odontogenic abscesses of the head and neck can lead to serious complications and even end in death. This requires healthcare professionals to have a good knowledge of all the markers of inflammation that can be used in their diagnosis and treatment. Such markers that we use in our daily medical practice are leukocytes (WBC), neutrophils (Neu), and C-reactive protein (CRP). Somehow, in the background is procalcitonin (PCT), which has not been studied in detail in this type of purulent infection. The aim of the present study is to investigate and analyze PCT in
odontogenic purulent infections of the head and neck in the female population and to compare it with already proven markers of inflammation such as CRP, WBC, and Neu. For the first time in the literature, as per our knowledge, the sensitivity, specificity, and predictability of PCT were determined when using it as an independent indicator of inflammation, and its cut-off reference values were determined in women with
odontogenic abscesses of the head and neck. Materials and methods This is a prospective study, in which the CRP, WBC, Neu, and PCT of 30 women with odontogenic abscesses of the head and neck with a mean age of 47 (18-81) years were examined and analyzed. As a control group, we included 30 healthy women with a mean age of 48 (18-80) years, in whom there was no anamnestic and physical evidence of the presence of any infection in the last three months. The four markers were measured for the control group too. Results In the clinical group of women with
odontogenic abscesses of the head and neck, the average values of CRP, WBC, Neu, and PCT were significantly higher (p<0.0001) compared to the same in the control group of healthy women; CRP: 95.46±76.41 mg/l vs. 0.63±0.37 mg/l, WBC: 10.44±2.97x103/L vs. 6.5±1.49x103/L, Neu: 7.92±2.93x103/L vs. 4.03±1.07x103/L, PCT: 0.74±0.69 ng/ml vs. 0.14±0.08 ng/ml. Discussion PCT, as well as CRP, WBC, and Neu, increases its plasma concentration in women with
odontogenic abscesses of the head and neck and is extremely well positively correlated with them, with a high correlation with CRP and a significant correlation with WBC and Neu. In addition, PCT has a number of advantages over the other markers; it begins to increase its plasma concentration faster, reaches its maximum plasma concentration faster, normalizes its concentration faster after the infection subsides, and increases its blood level only in bacterial infection genesis. Conclusions PCT as a marker of inflammation not only positively correlates well with CRP, WBC, and Neu but also, with its advantages over them, it appears to be the most accurate indicator in the diagnosis, treatment, and follow-up of odontogenic head and neck abscesses in the near future; not only in women but also in the male and children\'s population. Its sensitivity, specificity, and predictability as an independent indicator of inflammation are 80%, 76.7%, and 83%, respectively, and its cut-off value of 0.225 ng/ml is lower than the generally accepted 0.5 ng/ml.