PDF(Pubmed)
Abstract：
Ameloblastoma in dogs most often has a highly conserved acanthomatous cell morphology and is recognized as canine acanthomatous ameloblastoma (CAA) while conventional ameloblastoma (CA) makes up a smaller yet morphologically diverse group of epithelial odontogenic tumors. In humans, a rare desmoplastic histological subtype has distinctive clinical, radiological, and microscopic features. Desmoplastic ameloblastoma (DA) has not previously been described in dogs, although it has been rarely referenced in the veterinary literature. This is the first thorough description of a case series of DA in dogs and describes clinical presentation, diagnostic imaging findings, histopathological features for diagnosis, and treatment outcome. Clinically, DA most often presents as a mass or swelling in the rostral mandible or maxilla of middle age to older dogs. On diagnostic imaging, the lesion has a radiolucent or mixed pattern with well-defined borders and variable loculation. As a solid, fibrous tumor with obscured odontogenic epithelium, DA is challenging to diagnose histologically and can mimic several other oral tumors, both benign and malignant. As an ameloblastoma, the biological behavior of DA is locally destructive yet benign and prognosis is favorable following surgical excision.
摘要：
犬的成釉细胞瘤通常具有高度保守的棘皮瘤细胞形态，被认为是犬棘皮瘤成釉细胞瘤（CAA），而常规成釉细胞瘤（CA）构成了较小但形态多样的上皮牙源性肿瘤组。在人类中,一种罕见的促纤维化组织学亚型具有独特的临床，放射学,微观特征。促纤维化成釉细胞瘤（DA）以前没有在狗中描述过，尽管它在兽医文献中很少被引用。这是对狗DA病例系列的首次全面描述，并描述了临床表现，诊断成像结果，诊断的组织病理学特征，和治疗结果。临床上,DA通常表现为中年至老年犬的头骨下颌骨或上颌骨中的肿块或肿胀。关于诊断成像，病变具有射线可透或混合模式，边界明确且位置可变。作为一个固体，牙源性上皮模糊的纤维瘤，DA在组织学诊断方面具有挑战性，并且可以模拟其他几种口腔肿瘤，良性和恶性。作为成釉细胞瘤，DA的生物学行为具有局部破坏性，但良性，手术切除后预后良好。
