{Reference Type}: Case Reports {Title}: Odontogenic Sarcomas of the Mandible. {Author}: Akers J;Geisler E;Qiu S;Konofaos P;Marwan H; {Journal}: Biomedicines {Volume}: 12 {Issue}: 3 {Year}: 2024 Mar 8 {Factor}: 4.757 {DOI}: 10.3390/biomedicines12030615 {Abstract}: Odontogenic sarcomas are exceedingly rare and account for less than 5% of all Maxillofacial Sarcomas. It usually affects the younger population. The posterior mandible is the most commonly affected site. Radiographically, it appears as a large destructive radiolucent lesion with ill-defined margins. Histopathological diagnosis is usually difficult. Surgery is the mainstay treatment. The role of chemotherapy and radiation therapy is not clear. Here, we present a case study of a 30-year-old female patient diagnosed with odontogenic sarcoma that impinged on her airway. The treatment and postoperative course will be discussed in detail.