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Abstract：
Ameloblastic carcinoma is a rare malignant odontogenic tumor that is further classified into being primary or secondary arising from a preexisting benign ameloblastoma. It affects the mandible in two thirds of the patients. There is no standard treatment protocol for this lesion but radicalsurgical excision with or without radiotherapy is reported in the majority of cases. In this paper, we present a case of a 22 year old male diagnosed with Ameloblastic carcinoma of the mandible with a clinical course of typical aggressiveness and extensive destruction. Histopathological examination of the incised biopsy showed a parakeratinized stratified squamous epithelium with underlying fibrous connective tissue stroma. The stroma is highly myxomatous and exhibits islands of odontogenic epithelium and chronic inflammatory cell infiltrates. Interlacing strands of odontogenic epithelium shows stellate reticulum-like cells and occasional areas of squamous metaplasia with cellular and nuclear pleomorphism. In addition, mitotic figures were noted. With the correlation of clinical, radiographic, and histological features, the lesion is diagnosed as ameloblastic carcinoma. The lesion was surgical excised and post-treatment follow-up for 6 months revealed no recurrence of the malignancy.
摘要：
成釉细胞癌是一种罕见的恶性牙源性肿瘤，可进一步分为原发性或继发性，源于先前存在的良性成釉细胞瘤。它影响了三分之二的患者的下颌骨。该病变没有标准的治疗方案，但在大多数情况下，有或没有放射治疗的根治性手术切除报告。在本文中,我们介绍了一例22岁的男性，诊断为下颌骨成釉细胞癌，具有典型的侵袭性和广泛破坏的临床过程。切开的活检的组织病理学检查显示，角化的复层鳞状上皮具有潜在的纤维结缔组织基质。基质是高度粘液瘤，并表现出牙源性上皮岛和慢性炎症细胞浸润。牙源性上皮的交错链显示星状网状细胞和偶尔的鳞状化生区域，具有细胞和核多态性。此外,注意到有丝分裂图。与临床的相关性，射线照相,和组织学特征，该病变被诊断为成釉细胞癌。手术切除病灶，治疗后随访6个月，未发现恶性肿瘤复发。
