背景:对于接受无创通气(NIV)的脓毒症患者,早期康复至关重要。坐式八段锦(SBE)是一种适用于卧床患者的高效早期康复运动。关于SBE对NIV脓毒症患者早期康复的影响尚无共识。本研究集中于SBE如何影响NIV脓毒症患者的早期康复。
方法:将96例NIV脓毒症患者随机分为接受常规康复锻炼的八段锦组(n=48)或接受常规康复锻炼的对照组(n=48)。主要结果是医学研究理事会(MRC)评分,和Barthel指数得分,NIV的持续时间,ICU住院时间,总停留时间,住院费用作为次要结果。
结果:共筛查了245例脓毒症患者,随机分配96个。该研究由96名参与者中的90名患者完成。结果显示,两组的MRC评分均增加,但是八段锦组肌肉力量的改善更明显,具有统计学意义(p<0.001)。两组患者转出ICU当天Barthel指数差异有统计学意义(P=0.028)。与对照组相比,八段锦组患者的NIV持续时间平均减少了24.09h,住院总时间平均减少了3.35d(p<0.05)。值得注意的是,八段锦组住院总费用明显降低。干预期间无严重不良事件发生。
结论:在脓毒症患者中,SBE似乎可以改善肌肉力量和日常生活活动(ADL),随着NIV的持续时间,总停留时间的长度,和住院费用。
背景:该研究在中国临床试验注册中心注册(www.chictr.org.cn),临床试验标识符ChiCTR1800015011(28/02/2018)。
BACKGROUND: For patients with sepsis receiving non-invasive ventilation (NIV), early rehabilitation is crucial. The Sitting Baduanjin (SBE) is an efficient early rehabilitation exercise suitable for bed patients. There is no consensus about the effect of SBE on the early rehabilitation of septic patients with NIV. This study focused on how the SBE affected the early rehabilitation of sepsis patients with NIV.
METHODS: 96 sepsis patients with NIV were randomly assigned to either an Baduanjin group that received the SBE based on the routine rehabilitation exercise (n = 48) or a control group (n = 48) that received routine rehabilitation exercise. The primary outcome was the Medical Research Council(MRC)score, and the Barthel Index score, the duration of NIV, length of ICU stay, length of total stay, hospitalization expense as secondary outcomes.
RESULTS: A total of 245 sepsis patients were screened, with 96 randomly assigned. The study was completed by 90 patients out of the 96 participants.Results revealed that the MRC score increased in both groups, but the improvement of muscle strength in Baduanjin group was more obvious, with statistical significance (p < 0.001).There was statistically significantly difference between the two groups in Barthel Index at the day of transfer out of ICU(P = 0.028).The patients in the Baduanjin group had an average reduction of 24.09 h in the duration of NIV and 3.35 days in total length of hospital stay compared with the control group (p < 0.05).Of note, the Baduanjin group had significantly reduction the total hospitalization expense. No serious adverse events occurred during the intervention period.
CONCLUSIONS: In patients with sepsis, the SBE appears to improve muscle strength and activities of daily living (ADL), and lowed the duration of NIV, the length of the total stay, and the hospitalization expense.
BACKGROUND: The study registered on the Chinese Clinical Trial Registry ( www.chictr.org.cn ), Clinical Trials identifier ChiCTR1800015011 (28/02/2018).