目的:在对非小细胞肺癌(NSCLC)患者进行的研究中,许多因素,如年龄,舞台,减肥,淋巴结,和胸膜受累已被证明会影响生存率。另一方面,全身炎症在增殖中起关键作用,迁移,入侵,和转移。据报道,炎症和基于营养的预后评分与NSCLC患者的生存相关。我们研究的目的是显示这些评分对NSCLC患者的生存和疾病进展的影响。
方法:中性粒细胞与淋巴细胞比率(NLR),血小板与淋巴细胞比率(PLR),改良的格拉斯哥预后评分(mGPS),回顾性分析102例1,2和3A期NSCLC患者的预后营养指数(PNI)值.
结果:NLR(p<0.001),PLR(p=0.001),PNI(p<0.001),和mGPS(p=0.001)变量显示出根据死亡率组的统计学差异。患者的NLR和PLR值较高。然而,存活患者的PNI值较高。NLR(p<0.001),PLR(p=0.004),PNI(p=0.001),和mGPS(p=0.015)变量在局部复发方面显示出统计学上的显着差异。PNI(p=0.001)和mGPS(p=0.001)在随访和治疗期间的远处转移发展方面显示出统计学上的显着差异。
结论:NLR,PLR,PNI,和mGPS是容易获得的非侵入性参数,并提供有关生存和疾病进程的预测信息。我们显示了这些参数对预后的影响。
OBJECTIVE: In studies conducted on non-small cell lung cancer (NSCLC) patients, many factors such as age, stage, weight loss, lymph node, and pleural involvement have been shown to affect survival. On the other hand, systemic inflammation plays a critical role in proliferation, migration, invasion, and metastasis. Inflammation and nutrition-based prognostic scores are reported to be associated with survival in patients with NSCLC. The aim of our study is to show the effects of these scores on survival and disease progression in NSCLC patients.
METHODS: Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), modified Glasgow prognostic score (mGPS), and prognostic nutritional index (PNI) values in 102 patients with stages 1, 2, and 3A NSCLC were analyzed retrospectively.
RESULTS: NLR (p < 0.001), PLR (p = 0.001), PNI (p < 0.001), and mGPS (p = 0.001) variables showed a statistically significant difference according to mortality groups. NLR and PLR values were higher in exitus patients. However, PNI values were higher in surviving patients. NLR (p < 0.001), PLR (p = 0.004), PNI (p = 0.001), and mGPS (p = 0.015) variables showed a statistically significant difference in terms of locoregional recurrence. PNI (p = 0.001) and mGPS (p = 0.001) in terms of distant metastasis development during follow-up and treatment showed a statistically significant difference.
CONCLUSIONS: NLR, PLR, PNI, and mGPS are easily accessible noninvasive parameters and provide predictive information about survival and disease course. We showed the effect of these parameters on the prognosis.