UNASSIGNED: Patients diagnosed with PLCNEC between 2007 and 2022 at the oncology center, were retrospectively included. Patients who underwent surgery were pathologically re-staged post-surgery. Potential prognostic parameters (neutrophil/lymphocyte ratio, platelet/lymphocyte ratio [PLR], panimmune inflammatory value, prognostic nutritional index and modified Glasgow prognostic score [mGPS]) were calculated at that time of diagnosis.
UNASSIGNED: Sixty patients were included. The median follow-up was 23 months. Thirty-eight patients initially diagnosed with early or locally advanced. The mGPS was identified as a poor prognostic factor that influenced disease free survival (DFS) fourfold (p = 0.03). All patients\' median OS was 45 months. Evaluating factors affecting OS in all patients, statistically significant relationships were observed between OS and the prognostic nutritional index (p = 0.001), neutrophil/lymphocyte ratio (p = 0.03), platelet/lymphocyte ratio (p = 0.002), and pan-immunoinflammatory value (p = 0.005). Upon multivariate analysis, the platelet/lymphocyte ratio was identified as an independent poor prognostic factor for OS, increasing the mortality risk by 5.4 times (p = 0.002).
UNASSIGNED: mGPS was significantly linked with prognosis in non-metastatic PLCNEC, with patients with higher mGPS exhibiting poorer long-term DFS. This finding contributes to the evolving understanding of PLCNEC. The multivariable predictive model we employed suggests that PLR is an independent predictor of OS at all stages. A lower PLR was correlated with worse overall survival. Thus, PLR can be a readily accessible and cost-effective prognostic factor in PLCNEC patients.
■2007年至2022年在肿瘤中心诊断为PLCNEC的患者,被回顾性地包括在内。接受手术的患者在手术后经病理重新分期。潜在的预后参数(中性粒细胞/淋巴细胞比率,血小板/淋巴细胞比率[PLR],泛免疫炎症价值,在诊断时计算预后营养指数和改良的格拉斯哥预后评分[mGPS])。
■纳入60例患者。中位随访时间为23个月。最初诊断为早期或局部晚期的38例患者。mGPS被确定为影响无病生存(DFS)四倍(p=0.03)的不良预后因素。所有患者的中位OS为45个月。评估影响所有患者OS的因素,在OS和预后营养指数之间观察到有统计学意义的关系(p=0.001),中性粒细胞/淋巴细胞比率(p=0.03),血小板/淋巴细胞比率(p=0.002),和泛免疫炎症值(p=0.005)。经过多变量分析,血小板/淋巴细胞比率被确定为OS的独立不良预后因素,死亡风险增加5.4倍(p=0.002)。
■mGPS与非转移性PLCNEC的预后显著相关,mGPS较高的患者表现出较差的长期DFS。这一发现有助于不断发展对PLCNEC的理解。我们采用的多变量预测模型表明,PLR在所有阶段都是操作系统的独立预测因子。较低的PLR与较差的总体生存率相关。因此,PLR可能是PLCNEC患者容易获得且具有成本效益的预后因素。