■乳腺癌(BC)被认为是性功能障碍的危险因素,这可能与诊断本身或肿瘤治疗有关。然而,在BC幸存者中,性功能障碍通常仍未被诊断和解决。
■该研究旨在评估绝经后BC幸存者与无BC的绝经后妇女的性功能。
■这项病例对照研究包括178名绝经后BC幸存者(I-III期),45到70岁,闭经≥12个月,性生活活跃。他们与178名没有BC的女性进行了比较,自绝经以来的年龄和时间匹配(±2岁),比例为1:1。使用女性性功能指数(FSFI)评估性功能,它由6个域(欲望,唤醒,润滑,性高潮,满意,和痛苦),总分≤26.5,表明性功能障碍的风险。统计分析包括学生t检验,卡方检验,和逻辑回归(比值比[OR])。
■评估接受BC治疗的绝经后妇女的性功能。
■绝经后BC幸存者在欲望域中表现出较差的性功能(P=0.002)。在其他FSFI域和总分方面,组间没有观察到显著差异(P>.05)。与对照组(51.6%)相比,绝经后BC幸存者的性功能障碍风险较高(64.6%,总分≤26.5)(P=.010)。对绝经后年龄和时间的调整风险分析显示,与没有癌症的女性相比,BC幸存者发生性功能障碍的风险更高(OR,1.98;95%置信区间,1.29-2.96;P=.007)。在BC幸存者中,使用激素治疗与更高的性功能障碍风险相关(OR,3.46;95%置信区间,1.59-7.51;P=.002)。
■应在治疗前和整个过程中定期评估绝经后BC幸存者,以便早期发现和诊断性功能障碍。
■主要优势在于,与没有BC的女性相比,这项研究可能有助于更好地了解绝经后BC幸存者的性功能。主要的局限性是,虽然FSFI是评估女性性功能的有效和可靠的工具,它不允许对性功能障碍进行全面诊断,因为它不适用于合作伙伴。
■与没有BC的绝经后妇女相比,绝经后BC幸存者面临更高的性功能障碍风险,特别是在用辅助激素治疗时。
UNASSIGNED: Breast cancer (BC) is considered a risk factor for sexual dysfunction, which may be associated with the diagnosis itself or with oncological treatments. However, sexual dysfunction often remains underdiagnosed and unaddressed among BC survivors.
UNASSIGNED: The study sought to evaluate the sexual function of postmenopausal BC survivors compared with postmenopausal women without BC.
UNASSIGNED: This case-control study included 178 postmenopausal BC survivors (stages I-III), 45 to 70 years of age, with amenorrhea for ≥12 months and sexually active. They were compared with 178 women without BC, matched (±2 years) for age and time since
menopause in a 1:1 ratio. Sexual function was evaluated using the Female Sexual Function Index (FSFI), which consists of 6 domains (desire, arousal, lubrication, orgasm, satisfaction, and pain), with a total score ≤26.5 indicating risk of sexual dysfunction. Statistical analysis included Student\'s t test, chi-square test, and logistic regression (odds ratio [OR]).
UNASSIGNED: Evaluation of sexual function in postmenopausal women treated for BC.
UNASSIGNED: Postmenopausal BC survivors showed poorer sexual function in the desire domain (P = .002). No significant differences were observed between groups in the other FSFI domains and total score (P > .05). Postmenopausal BC survivors had a higher prevalence of risk of sexual dysfunction (64.6% with a total score ≤26.5) compared with the control group (51.6%) (P = .010). Adjusted risk analysis for age and time since
menopause revealed a higher risk of sexual dysfunction in BC survivors compared with women without cancer (OR, 1.98; 95% confidence interval, 1.29-2.96; P = .007). Among BC survivors, the use of hormone therapy was associated with a higher risk of sexual dysfunction (OR, 3.46; 95% confidence interval, 1.59-7.51; P = .002).
UNASSIGNED: Postmenopausal BC survivors should be regularly assessed before and throughout treatment to enable the early detection and diagnosis of sexual dysfunction.
UNASSIGNED: The main strength is that this study might contribute to a better understanding of sexual function in postmenopausal BC survivors compared with women without BC. The main limitation is that while the FSFI is a valid and reliable tool for the evaluation of female sexual function, it does not allow a comprehensive diagnosis of sexual dysfunction, as it is not applicable to partners.
UNASSIGNED: Compared with postmenopausal women without BC, postmenopausal BC survivors face a higher risk of sexual dysfunction, especially when treated with adjuvant hormone therapy.