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Abstract：
BACKGROUND: Women at middle age are puzzled by a series of menopausal disturbances, can be distressing and considerably affect the personal, social and work lives. We aim to estimate the global prevalence of nineteen menopausal symptoms among middle-aged women by performing a systematic review and meta-analysis.
METHODS: Comprehensive search was performed in multiple databases from January, 2000 to March, 2023 for relevant studies. Random-effect model with double-arcsine transformation was used for data analysis.
RESULTS: A total of 321 studies comprised of 482,067 middle-aged women were included for further analysis. We found varied prevalence of menopausal symptoms, with the highest prevalence of joint and muscular discomfort (65.43%, 95% CI 62.51-68.29) and lowest of formication (20.5%, 95% CI 13.44-28.60). Notably, South America shared dramatically high prevalence in a sort of menopausal symptoms including depression and urogenital symptoms. Besides, countries with high incomes (49.72%) had a significantly lower prevalence of hot flashes than those with low (65.93%), lower-middle (54.17%), and upper-middle (54.72%, p < 0.01), while personal factors, such as menopausal stage, had an influence on most menopausal symptoms, particularly in vaginal dryness. Prevalence of vagina dryness in postmenopausal women (44.81%) was 2-fold higher than in premenopausal women (21.16%, p < 0.01). Furthermore, a remarkable distinction was observed between body mass index (BMI) and prevalence of sleep problems, depression, anxiety and urinary problems.
CONCLUSIONS: The prevalence of menopausal symptoms affected by both social and personal factors which calls for attention from general public.
METHODS: Comprehensive search was performed in multiple databases from January, 2000 to March, 2023 for relevant studies. Random-effect model with double-arcsine transformation was used for data analysis.
RESULTS: A total of 321 studies comprised of 482,067 middle-aged women were included for further analysis. We found varied prevalence of menopausal symptoms, with the highest prevalence of joint and muscular discomfort (65.43%, 95% CI 62.51-68.29) and lowest of formication (20.5%, 95% CI 13.44-28.60). Notably, South America shared dramatically high prevalence in a sort of menopausal symptoms including depression and urogenital symptoms. Besides, countries with high incomes (49.72%) had a significantly lower prevalence of hot flashes than those with low (65.93%), lower-middle (54.17%), and upper-middle (54.72%, p < 0.01), while personal factors, such as menopausal stage, had an influence on most menopausal symptoms, particularly in vaginal dryness. Prevalence of vagina dryness in postmenopausal women (44.81%) was 2-fold higher than in premenopausal women (21.16%, p < 0.01). Furthermore, a remarkable distinction was observed between body mass index (BMI) and prevalence of sleep problems, depression, anxiety and urinary problems.
CONCLUSIONS: The prevalence of menopausal symptoms affected by both social and personal factors which calls for attention from general public.
摘要：
背景：中年女性对一系列更年期障碍感到困惑，可能会令人痛苦，并对个人产生相当大的影响，社会和工作生活。我们旨在通过系统评价和荟萃分析来估计中年妇女中19种更年期症状的全球患病率。
方法：从1月开始在多个数据库中进行全面搜索，2000年3月,2023年进行相关研究。采用双反正弦变换的随机效应模型进行数据分析。
结果：共321项研究，包括482,067名中年妇女，用于进一步分析。我们发现更年期症状的患病率不同，关节和肌肉不适的患病率最高(65.43%，95%CI62.51-68.29）和最低的正式治疗（20.5%，95%CI13.44-28.60）。值得注意的是,南美在某种更年期症状中的患病率极高，包括抑郁症和泌尿生殖道症状。此外,高收入国家（49.72％）的潮热患病率明显低于低收入国家（65.93％），中下层(54.17%)，和中上层(54.72%，p<0.01),而个人因素,如更年期，对大多数更年期症状有影响，特别是在阴道干燥。绝经后妇女阴道干燥的患病率(44.81%)比绝经前妇女高2倍(21.16%,p<0.01)。此外，在体重指数（BMI）和睡眠问题的患病率之间观察到显着的区别，抑郁症,焦虑和泌尿问题。
结论：更年期症状的患病率受社会和个人因素的影响，需要引起公众的关注。
方法：从1月开始在多个数据库中进行全面搜索，2000年3月,2023年进行相关研究。采用双反正弦变换的随机效应模型进行数据分析。
结果：共321项研究，包括482,067名中年妇女，用于进一步分析。我们发现更年期症状的患病率不同，关节和肌肉不适的患病率最高(65.43%，95%CI62.51-68.29）和最低的正式治疗（20.5%，95%CI13.44-28.60）。值得注意的是,南美在某种更年期症状中的患病率极高，包括抑郁症和泌尿生殖道症状。此外,高收入国家（49.72％）的潮热患病率明显低于低收入国家（65.93％），中下层(54.17%)，和中上层(54.72%，p<0.01),而个人因素,如更年期，对大多数更年期症状有影响，特别是在阴道干燥。绝经后妇女阴道干燥的患病率(44.81%)比绝经前妇女高2倍(21.16%,p<0.01)。此外，在体重指数（BMI）和睡眠问题的患病率之间观察到显着的区别，抑郁症,焦虑和泌尿问题。
结论：更年期症状的患病率受社会和个人因素的影响，需要引起公众的关注。
