背景:尽管有强有力的证据支持运动对压力引起的影响的保护作用,关于代谢方面的文献仍然没有定论。因此,本研究旨在评估游泳运动对束缚应激大鼠代谢参数的影响。
方法:Wistar大鼠(n=40)分为4组:对照组(C),受过训练(T),强调(S),和训练/强调(TS)。约束应激方案涉及将动物限制在PVC管中60分钟/天,持续12周。同时,游泳PT方案是在没有额外负荷的情况下进行的,需要在相同持续时间内每周5天进行60分钟的疗程.分析了以下参数:通过体能测试评估的健身进展,体重,血清葡萄糖水平,甘油三酯,胆固醇和皮质酮,以及血糖耐受性测试,葡萄糖给药后评估(2g/kg,i.p.)。
结果:训练组(T和TS)表现出增强的身体能力(增加169±21和162±22%,分别)与未经训练的组相比(C:9±5和S:11±13%增加)。S组皮质酮水平(335±9nmoL/L)明显高于C组(141±3nmoL/L),T(174±3nmoL/L)和TS(231±7nmoL/L),它们彼此没有区别。血清葡萄糖无明显变化,胆固醇,和甘油三酯水平。然而,葡萄糖负荷后的血糖曲线显示S组的血糖升高(曲线下面积913±30AU),但TS组的血糖值(673±12AU)与C组(644±10AU)和T组(649±9AU)相似.
结论:以游泳为基础的训练可减弱大鼠应激诱导的皮质酮释放并预防葡萄糖不耐受,加强运动作为减轻应激病理生理影响的潜在策略的重要性。
Despite strong evidences supporting the protective role of exercise against stress-induced repercussions, the literature remains inconclusive regarding metabolic aspects. Therefore, this study aimed to evaluate the effect of Physical Training (PT) by swimming on the metabolic parameters of rats subjected to restraint stress.
Wistar rats (n = 40) were divided into four groups: Control (C), Trained (T), Stressed (S), and Trained/Stressed (TS). The restraint stress protocol involved confining the animals in PVC pipes for 60 minutes/day for 12 weeks. Concurrently, the swimming PT protocol was performed without additional load in entailed sessions of 60 minutes conducted five days a week for the same duration. The following parameters were analyzed: fitness progression assessed by the physical capacity test, body mass, serum level of glucose, triglyceride, cholesterol and corticosterone, as well as glycemic tolerance test, evaluated after glucose administration (2 g/kg, i.p.).
Trained groups (T and TS) exhibited enhanced physical capacity (169 ± 21 and 162 ± 22% increase, respectively) compared to untrained groups (C: 9 ± 5 and S: 11 ± 13% increase). Corticosterone levels were significantly higher in the S group (335 ± 9 nmoL/L) compared to C (141 ± 3 nmoL/L), T (174 ± 3 nmoL/L) and TS (231 ± 7 nmoL/L), which did not differ from each other. There were no significant changes in serum glucose, cholesterol, and triglyceride levels among the groups. However, the glycemic curve after glucose loading revealed increased glycemia in the S group (area under curve 913 ± 30 AU) but the TS group exhibited values (673 ± 12 AU) similar to the groups C (644 ± 10 AU) and T (649 ± 9 AU).
Swimming-based training attenuated stress-induced corticosterone release and prevented glucose intolerance in rats, reinforcing the importance of exercise as a potential strategy to mitigate the pathophysiological effects of stress.