PDF(Pubmed)
Abstract：
UNASSIGNED: Antenatal iron deficiency and anaemia are associated with gestational hypertension and diabetes mellitus, but so are elevated iron stores and haemoglobin. In South Africa, pregnant women receive routine iron supplementation regardless of iron status.
UNASSIGNED: This study aimed to assess associations of antenatal iron status and anaemia with blood pressure in pregnant women in urban South Africa. Secondary to this, associations with heart rate, fasting glucose and glucose tolerance were also investigated.
UNASSIGNED: Johannesburg, South Africa.
UNASSIGNED: A total of 250 pregnant women, aged 27 (24-32) years, were recruited using consecutive sampling. The authors measured biomarkers of iron status and anaemia at < 18 and ± 22 weeks\', blood pressure and heart rate at ± 36 weeks\', and fasting glucose and glucose tolerance between 24 and 28 weeks\' gestation. Associations were determined using multivariable regression models adjusted for confounders.
UNASSIGNED: The odds of prehypertension in late pregnancy among women with anaemia at ± 22 weeks\' gestation were three times higher than among women without anaemia (odds ratio [OR]: 3.01, 95% confidence interval [CI]: 1.22, 7.42). Participants with anaemia at ± 22 weeks\' gestation had 2.15 times higher odds of having elevated mean arterial pressure than women without anaemia (OR: 2.15, 95% CI: 1.01, 4.60).
UNASSIGNED: Anaemia at mid-pregnancy could be a predictor of hypertensive disorders in pregnancy. The cause of antenatal anaemia may need further investigation apart from iron deficiency. The effective management of anaemia in pregnant women living in urban South Africa remains a challenge.
UNASSIGNED: This study provides evidence about the health impact of pregnant women regarding antenatal supplementation practices in South Africa.
UNASSIGNED: This study aimed to assess associations of antenatal iron status and anaemia with blood pressure in pregnant women in urban South Africa. Secondary to this, associations with heart rate, fasting glucose and glucose tolerance were also investigated.
UNASSIGNED: Johannesburg, South Africa.
UNASSIGNED: A total of 250 pregnant women, aged 27 (24-32) years, were recruited using consecutive sampling. The authors measured biomarkers of iron status and anaemia at < 18 and ± 22 weeks\', blood pressure and heart rate at ± 36 weeks\', and fasting glucose and glucose tolerance between 24 and 28 weeks\' gestation. Associations were determined using multivariable regression models adjusted for confounders.
UNASSIGNED: The odds of prehypertension in late pregnancy among women with anaemia at ± 22 weeks\' gestation were three times higher than among women without anaemia (odds ratio [OR]: 3.01, 95% confidence interval [CI]: 1.22, 7.42). Participants with anaemia at ± 22 weeks\' gestation had 2.15 times higher odds of having elevated mean arterial pressure than women without anaemia (OR: 2.15, 95% CI: 1.01, 4.60).
UNASSIGNED: Anaemia at mid-pregnancy could be a predictor of hypertensive disorders in pregnancy. The cause of antenatal anaemia may need further investigation apart from iron deficiency. The effective management of anaemia in pregnant women living in urban South Africa remains a challenge.
UNASSIGNED: This study provides evidence about the health impact of pregnant women regarding antenatal supplementation practices in South Africa.
摘要：
产前缺铁和贫血与妊娠期高血压和糖尿病有关，但是铁储备和血红蛋白升高也是如此。在南非,孕妇接受常规补铁，无论铁的状态。
本研究旨在评估南非城市孕妇产前铁状态和贫血与血压的关系。其次，与心率有关，我们还研究了空腹血糖和糖耐量.
■约翰内斯堡，南非。
■共有250名孕妇,27岁（24-32岁），采用连续抽样招募。作者在<18周和±22周测量了铁状态和贫血的生物标志物，±36周时的血压和心率，妊娠24至28周之间的空腹血糖和糖耐量。使用校正混杂因素的多变量回归模型确定关联。
■妊娠±22周贫血妇女妊娠晚期高血压前期的几率是无贫血妇女的三倍（比值比[OR]：3.01，95％置信区间[CI]：1.22，7.42）。妊娠±22周时贫血的参与者平均动脉压升高的几率是无贫血女性的2.15倍(OR:2.15,95%CI:1.01,4.60)。
■妊娠中期贫血可能是妊娠期高血压疾病的预测因素。除了铁缺乏，产前贫血的原因可能需要进一步调查。生活在南非城市的孕妇贫血的有效管理仍然是一个挑战。
这项研究提供了有关南非孕妇产前补充措施对健康影响的证据。
本研究旨在评估南非城市孕妇产前铁状态和贫血与血压的关系。其次，与心率有关，我们还研究了空腹血糖和糖耐量.
■约翰内斯堡，南非。
■共有250名孕妇,27岁（24-32岁），采用连续抽样招募。作者在<18周和±22周测量了铁状态和贫血的生物标志物，±36周时的血压和心率，妊娠24至28周之间的空腹血糖和糖耐量。使用校正混杂因素的多变量回归模型确定关联。
■妊娠±22周贫血妇女妊娠晚期高血压前期的几率是无贫血妇女的三倍（比值比[OR]：3.01，95％置信区间[CI]：1.22，7.42）。妊娠±22周时贫血的参与者平均动脉压升高的几率是无贫血女性的2.15倍(OR:2.15,95%CI:1.01,4.60)。
■妊娠中期贫血可能是妊娠期高血压疾病的预测因素。除了铁缺乏，产前贫血的原因可能需要进一步调查。生活在南非城市的孕妇贫血的有效管理仍然是一个挑战。
这项研究提供了有关南非孕妇产前补充措施对健康影响的证据。
