羟考酮,经常用作镇痛药,是一种有效的阿片类药物。虽然其有效性已在控制中度至急性疼痛中得到证明,过度使用羟考酮会导致心力衰竭,心悸,减少红细胞,骨痛,甚至死亡。因此,监测血液中的羟考酮浓度对于急诊护理至关重要。为此,基于介孔g-C3N4(M-C3N4)修饰的玻碳电极,设计了一种新型的电化学传感器,氮掺杂碳纳米洋葱(N-CNO),和金纳米粒子。起初,采用SEM和XRD技术对制备的M-C3N4和N-CNO样品进行了表征。通过循环和差分脉冲伏安法评估羟考酮的电氧化行为。基于电位扫描速率和溶液pH对羟考酮氧化伏安响应的影响,提出了一种氧化还原机理。对于羟考酮分析获得16nM的检测限,线性响应在0.05-150μM范围内。该传感器显示出在血浆样品中检测羟考酮的显着能力。长期稳定,优越的选择性,该传感器的再现性证明了其在正宗香料中准确和精确地测量羟考酮的能力。
Oxycodone, often used as an analgesic, is a potent opioid. While its effectiveness has been proven in the control of moderate to acute pain, excessive use of oxycodone imposes heart failure, heart palpitations, reduction of red blood cells, bone pain, and even death. Therefore, monitoring the oxycodone concentration in blood is vital for emergency care. For this purpose, a novel electrochemical sensor was designed based on a glassy carbon electrode modified with mesoporous g-C3N4 (M-C3N4), carbon nano-onions doped with nitrogen (N-CNO), and gold nanoparticles. At first, the SEM and XRD techniques were employed to characterize prepared M-C3N4 and N-CNO samples. The electro-oxidation behavior of the oxycodone was evaluated by cyclic and differential pulse voltammetric methods. Based on the influence of the potential scanning rate and solution pH on the voltammetric response of oxycodone oxidation, a redox mechanism was proposed. A 16 nM detection limit was acquired for the oxycodone analysis with a linear response in the 0.05-150 µM range. This sensor showed a remarkable ability for oxycodone detection in plasma samples. The long-term stability, superior selectivity, and reproducibility of this sensor prove its ability to measure oxycodone accurately and precisely in authentic spices.