Abstract:
Metal-organic frameworks (MOFs) with their exceptional properties have the potential to revolutionize the field of electrochemistry and pave the way for new and exciting applications. MOFs is an excellent choice as an active electrocatalyst component in the fabrication of electrochemical sensors. Here, bimetallic NiCo-MOFs, monometallic Ni-MOFs, and Co-MOFs were fabricated to modify the carbon paste electrode. Moreover, the ratio between Co and Ni within the bimetallic MOFs was optimized. Our aim in this work is to synthesize different compositions from bimetallic MOFs and systematically compare their catalytic activity with mono-metallic MOFs on paracetamol. The structure and properties of the 2D NiCo-MOFs were characterized by scanning electron microscope, X-ray photoelectron spectroscopy, Fourier transform infrared, and electrochemical method. Bimetallic Ni0.75Co0.25-MOFs modified carbon paste sensor displayed the optimum sensing performance for the electrochemical detection of paracetamol. A linear response over the range 6.00 × 10- 7 to 1.00 × 10- 4 M with a detection limit of 2.10 × 10- 8 M was obtained. The proposed method was applied to detect paracetamol in spiked human plasma and to determine paracetamol in the presence of its major toxic impurity, p-aminophenol. These findings suggest the considerable potential use of the newly developed sensor as a point-of-care tool for detecting paracetamol and p-aminophenol in the future.
摘要:
金属有机框架(MOFs)具有其卓越的性能,有可能彻底改变电化学领域,并为新的令人兴奋的应用铺平道路。MOFs作为电化学传感器制造中的活性电催化剂组分是极好的选择。这里,双金属NiCo-MOFs,单金属Ni-MOFs,和Co-MOFs被制造以改性碳糊电极。此外,优化了双金属MOFs中Co和Ni的比例。我们在这项工作中的目标是从双金属MOFs合成不同的组合物,并系统地比较它们与对乙酰氨基酚的单金属MOFs的催化活性。通过扫描电子显微镜对2DNiCo-MOFs的结构和性能进行了表征,X射线光电子能谱,傅里叶变换红外,和电化学方法。双金属Ni0.75Co0.25-MOFs改性碳糊传感器在对乙酰氨基酚的电化学检测中表现出最佳的传感性能。在6.00×10-7至1.00×10-4M范围内获得线性响应,检出限为2.10×10-8M。所提出的方法用于检测加标的人血浆中的扑热息痛,并在存在其主要有毒杂质的情况下测定扑热息痛,对氨基苯酚。这些发现表明,新开发的传感器具有相当大的潜在用途,可以作为将来检测对乙酰氨基酚和对氨基苯酚的即时护理工具。