背景和目的:日本代谢功能障碍相关的脂肪变性肝病(MASLD)和相关的代谢功能障碍的趋势尚不清楚。因此,我们的目的是在日本2019年新型冠状病毒病大流行之前澄清这些趋势。材料和方法:我们包括在我们中心接受健康检查的25-79岁的日本人。我们分析了人体测量学,与生活方式有关的疾病,和营养摄入量与2010-2019年MASLD趋势的关系。结果:MASLD的患病率在所有年龄和体重指数(BMI)类别中都有所增加,男性达到30.3%,女性达到16.1%,MASLD占脂肪变性肝脏病例的75%,占所有2型糖尿病(T2DM)和高腰围(HWC)病例的一半以上。MASLD患病率的增加被认为主要归因于脂肪变性肝脏发病率的增加。其他因素的患病率没有增加,比如超重,T2DM,高血压,和血脂异常。葡萄糖代谢紊乱(GMDs)和高血压的患病率下降。国家营养数据显示能量摄入增加,总脂肪,饱和脂肪酸,单不饱和脂肪酸,和多不饱和脂肪酸,这与GMDs的减少有关。盐的摄入量也减少了,这与高血压有关。MASLD组所有相关代谢因子的患病率均高于非MASLD组,尤其是HWC,T2DM,和高脂血症。结论:MASLD的患病率随着脂肪变性肝脏的患病率而增加,无论年龄或BMI。增加膳食脂肪之间的关系,增加的脂肪变性的肝脏,并建议减少GMDs。
Background and Objectives: The trends in metabolic dysfunction-associated steatotic liver disease (MASLD) and related metabolic dysfunctions in Japan are unknown. Thus, we aimed to clarify these trends before the novel coronavirus disease 2019 pandemic in Japan. Materials and Methods: We included Japanese individuals aged 25-79 years who underwent health examinations at our center. We analyzed anthropometry, lifestyle-related disease, and nutritional intake in relation to MASLD trends from 2010-2019. Results: The prevalence of MASLD increased in all ages and body mass index (BMI) classes, reaching 30.3% in males and 16.1% in females, with MASLD accounting for 75% of steatotic liver cases and more than half of all type 2 diabetes mellitus (T2DM) and high waist circumference (HWC) cases. The increase in the prevalence of MASLD was thought to be largely attributable to an increase in that of the incidence of steatotic liver itself, and there was no increase in the prevalence of other factors, such as overweight, T2DM, hypertension, and dyslipidemia. The prevalence of glucose metabolic disorders (GMDs) and hypertension decreased. National nutritional data showed an increase in energy intake, total fat, saturated fatty acids, monounsaturated fatty acids, and polyunsaturated fatty acids, which correlated with a decrease in GMDs. Salt intake also decreased, which correlated with hypertension. The MASLD group had a higher prevalence of all related metabolic factors than the non-MASLD group, especially HWC, T2DM, and hyperlipidemia. Conclusions: The prevalence of MASLD increased with that of steatotic liver, regardless of age or BMI. A relationship between increased dietary fat, increased steatotic liver, and decreased GMDs was suggested.