PDF(Pubmed)
Abstract：
Perinatal exposure to omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) can be characterized through biomarkers in maternal or cord blood or breast milk. Objectives were to describe perinatal PUFA status combining multiple biofluids and to investigate how it was influenced by dietary intake during pregnancy and maternal FADS and ELOVL gene polymorphisms. This study involved 1,901 mother-child pairs from the EDEN cohort, with PUFA levels measured in maternal and cord erythrocytes, and colostrum. Maternal dietary PUFA intake during the last trimester was derived from a food frequency questionnaire. Twelve single-nucleotide polymorphisms in FADS and ELOVL genes were genotyped from maternal DNA. Principal component analysis incorporating PUFA levels from the three biofluids identified patterns of perinatal PUFA status. Spearman\'s correlations explored associations between patterns and PUFA dietary intake, and linear regression models examined pattern associations with FADS or ELOVL haplotypes. Five patterns were retained: \"High omega-3 LC-PUFAs, low omega-6 LC-PUFAs\"; \"Omega-6 LC-PUFAs\"; \"Colostrum LC-PUFAs\"; \"Omega-6 precursor (LA) and DGLA\"; \"Omega-6 precursor and colostrum ALA\". Maternal omega-3 LC-PUFA intakes were correlated with \"High omega-3 LC-PUFAs, low omega-6 LC-PUFAs\" (r(DHA) = 0.33) and \"Omega-6 LC-PUFAs\" (r(DHA) = -0.19) patterns. Strong associations were found between FADS haplotypes and PUFA patterns except for \"High omega-3 LC-PUFAs, low omega-6 LC-PUFAs\". Lack of genetic association with the \"High omega-3 LC-PUFAs, low omega-6 LC-PUFAs\" pattern, highly correlated with maternal omega-3 LC-PUFA intake, emphasizes the importance of adequate omega-3 LC-PUFA intake during pregnancy and lactation. This study offers a more comprehensive assessment of perinatal PUFA status and its determinants.
摘要：
围产期暴露于omega-3和omega-6多不饱和脂肪酸（PUFA）可以通过母体或脐带血中的生物标志物来表征。或母乳。目标是描述围产期PUFA状态结合多种生物液体，并探讨其如何受孕期膳食摄入和母体FADS和ELOVL基因多态性的影响。这项研究涉及来自EDEN队列的1,901对母子，在母体和脐带红细胞中测量PUFA水平，还有初乳.最后三个月的母体饮食PUFA摄入量来自食物频率问卷。从母体DNA对FADS和ELOVL基因中的12个单核苷酸多态性进行了基因分型。结合来自三种生物流体的PUFA水平的主成分分析确定了围产期PUFA状态的模式。Spearman的相关性探讨了模式与PUFA饮食摄入量之间的关联，和线性回归模型检查了与FADS或ELOVL单倍型的模式关联。保留了五种模式：“高omega-3LC-PUFA，低omega-6LC-PUFAs\";\"Omega-6LC-PUFAs\";\"初乳LC-PUFAs\";\"Omega-6前体(LA)和DGLA\";\"Omega-6前体和初乳ALA\"。母亲的omega-3LC-PUFA摄入量与高omega-3LC-PUFA相关，低omega-6LC-PUFAs“(r(DHA)=0.33)和”Omega-6LC-PUFAs“(r(DHA)=-0.19)模式。在FADS单倍型和PUFA模式之间发现了强烈的关联，除了高omega-3LC-PUFA，低omega-6LC-PUFA。“缺乏与高omega-3LC-PUFA的遗传关联，低omega-6LC-PUFAs“模式，与母体omega-3LC-PUFA摄入量高度相关，强调在怀孕和哺乳期间摄入足够的omega-3LC-PUFA的重要性。这项研究提供了围产期PUFA状态及其决定因素的更全面评估。
