PDF(Pubmed)
Abstract：
OBJECTIVE: A meta-analysis study was performed to systematically assess the association between tea consumption and CRC risk.
METHODS: Cochrane Library, Embase, PubMed, and Web of Science were retrieved to collect articles in English since 24 July 2023. Databases were searched and evaluated by two reviewers independently.We screened the literature based on inclusion and exclusion criteria. After determining the random effect model or fixed utility model based on a heterogeneity test, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.
RESULTS: We included fourteen articles in this meta-analysis. We analyzed the data using a random effect model to explore the association between tea consumption and CRC because of apparent heterogeneity (P < 0.001, I2 = 99.5%). The combined results of all tests showed that there is no statistically significant association between tea consumption and CRC risk (OR = 0.756, 95%CI = 0.470-1.215, P = 0.247). Subsequently, subgroup analysis and sensitivity analysis were performed. Excluding any single study, the overall results ranged from 0.73 (95%CI = 0.44-1.20) to 0.86 (95%CI = 0.53-1.40). It was determined that there was no significant publication bias between tea consumption and CRC risk (P = 0.064) by Egger\'s tests.
CONCLUSIONS: The results indicated that tea consumption may not be significantly associated with the development of CRC.
CONCLUSIONS: Tea reduces colon cancer risk by 24%, but the estimate is uncertain. The actual effect on risk can range from a reduction of 51% to an increase of 18%, but regional and population differences may cause differences.
METHODS: Cochrane Library, Embase, PubMed, and Web of Science were retrieved to collect articles in English since 24 July 2023. Databases were searched and evaluated by two reviewers independently.We screened the literature based on inclusion and exclusion criteria. After determining the random effect model or fixed utility model based on a heterogeneity test, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.
RESULTS: We included fourteen articles in this meta-analysis. We analyzed the data using a random effect model to explore the association between tea consumption and CRC because of apparent heterogeneity (P < 0.001, I2 = 99.5%). The combined results of all tests showed that there is no statistically significant association between tea consumption and CRC risk (OR = 0.756, 95%CI = 0.470-1.215, P = 0.247). Subsequently, subgroup analysis and sensitivity analysis were performed. Excluding any single study, the overall results ranged from 0.73 (95%CI = 0.44-1.20) to 0.86 (95%CI = 0.53-1.40). It was determined that there was no significant publication bias between tea consumption and CRC risk (P = 0.064) by Egger\'s tests.
CONCLUSIONS: The results indicated that tea consumption may not be significantly associated with the development of CRC.
CONCLUSIONS: Tea reduces colon cancer risk by 24%, but the estimate is uncertain. The actual effect on risk can range from a reduction of 51% to an increase of 18%, but regional and population differences may cause differences.
摘要：
目的：进行了一项荟萃分析研究，以系统地评估饮茶与CRC风险之间的关系。
方法：Cochrane图书馆，Embase,PubMed,自2023年7月24日以来，检索了WebofScience以收集英文文章。由两个独立的审阅者搜索和评估数据库。我们根据纳入和排除标准筛选了文献。在基于异质性检验确定随机效应模型或固定效用模型后，计算比值比(OR)和95%置信区间(CI).
结果：我们在这项荟萃分析中纳入了14篇文章。我们使用随机效应模型分析数据，以探索茶消费与CRC之间的关联，因为明显的异质性（P<0.001，I2=99.5％）。所有测试的综合结果表明，饮茶量与CRC风险之间没有统计学上的显着关联（OR=0.756，95CI=0.470-1.215，P=0.247）。随后，进行亚组分析和敏感性分析.不包括任何一项研究，总体结果范围为0.73(95CI=0.44-1.20)至0.86(95CI=0.53-1.40).通过Egger检验，确定茶消费和CRC风险之间没有显著的发表偏倚（P=0.064）。
结论：结果表明，饮茶可能与CRC的发展没有显著关联。
结论：茶可将结肠癌风险降低24%，但是估计是不确定的。对风险的实际影响范围从减少51%到增加18%，但是地区和人口差异可能会导致差异。
方法：Cochrane图书馆，Embase,PubMed,自2023年7月24日以来，检索了WebofScience以收集英文文章。由两个独立的审阅者搜索和评估数据库。我们根据纳入和排除标准筛选了文献。在基于异质性检验确定随机效应模型或固定效用模型后，计算比值比(OR)和95%置信区间(CI).
结果：我们在这项荟萃分析中纳入了14篇文章。我们使用随机效应模型分析数据，以探索茶消费与CRC之间的关联，因为明显的异质性（P<0.001，I2=99.5％）。所有测试的综合结果表明，饮茶量与CRC风险之间没有统计学上的显着关联（OR=0.756，95CI=0.470-1.215，P=0.247）。随后，进行亚组分析和敏感性分析.不包括任何一项研究，总体结果范围为0.73(95CI=0.44-1.20)至0.86(95CI=0.53-1.40).通过Egger检验，确定茶消费和CRC风险之间没有显著的发表偏倚（P=0.064）。
结论：结果表明，饮茶可能与CRC的发展没有显著关联。
结论：茶可将结肠癌风险降低24%，但是估计是不确定的。对风险的实际影响范围从减少51%到增加18%，但是地区和人口差异可能会导致差异。
