了解纳米颗粒的物理化学和生物相互作用对于纳米材料的生物医学应用是强制性的。通过结合蛋白质,纳米粒子在生物流体中获得新的表面身份,蛋白质电晕。各种研究揭示了蛋白质冠的动态结构和纳米生物相互作用。蛋白质的结合不仅赋予生物流体中的纳米颗粒新的表面身份,而且显着影响其生物活性,稳定性,和靶向特异性。有趣的是,最近的努力已经着手利用蛋白质电晕的潜力,而不是逃避它的存在。这种“蛋白质-纳米颗粒联盟”的开发具有改变纳米医学领域的巨大潜力。这里,我们对蛋白质电晕的最新研究进行了全面的研究,包括它的形成,动力学,最近的事态发展,和多样化的生物应用。此外,我们还旨在探索纳米生物界面的相互作用,为创新策略铺平道路,以提高蛋白质电晕的应用潜力。通过解决控制蛋白质电晕形成的挑战和承诺,这篇综述提供了对“蛋白质-纳米颗粒联盟”不断发展的格局的见解,并强调了新兴的发展。
Understanding both the physicochemical and biological interactions of nanoparticles is mandatory for the biomedical application of nanomaterials. By binding proteins, nanoparticles acquire new surface identities in biological fluids, the protein corona. Various studies have revealed the dynamic structure and nano-bio interactions of the protein corona. The binding of proteins not only imparts new surface identities to nanoparticles in biological fluids but also significantly influences their bioactivity, stability, and targeting specificity. Interestingly, recent endeavors have been undertaken to harness the potential of the protein corona instead of evading its presence. Exploitation of this \'protein-nanoparticle alliance\' has significant potential to change the field of nanomedicine. Here, we present a thorough examination of the latest research on protein corona, encompassing its formation, dynamics, recent developments, and diverse bioapplications. Furthermore, we also aim to explore the interactions at the nano-bio interface, paving the way for innovative strategies to advance the application potential of the protein corona. By addressing challenges and promises in controlling protein corona formation, this review provides insights into the evolving landscape of the \'protein-nanoparticle alliance\' and highlights emerging.