■鼻喷雾剂广泛用于治疗鼻和鼻窦疾病;然而,关于鼻腔喷雾剂给药效率的研究很少。在这项研究中,使用3D打印的鼻腔模型在体外评估了三种不同鼻腔喷雾装置的药物递送效率。
■在鼻腔和鼻旁窦的3D模型中使用了三种具有不同喷嘴和给药角度的鼻喷雾装置。喷涂面积(SA),最大喷涂距离(MSD),记录鼻中隔和鼻侧壁的喷雾分布评分。
■不同的鼻喷装置有自己的特点,包括每次喷雾的体积,SA,和羽流角度。鼻中隔上的三个喷嘴的SA随着给药角度的增加而增加。当给药角度为50°时,每个喷嘴达到最大SA。在三个角度下,三个喷嘴之间的MSD没有统计学上的显着差异。使用三种不同喷射角度的每个喷嘴的总分如下:喷嘴A,40°>30°>50°;喷嘴B,30°>40°>50°;和喷嘴C,30°>40°>50°。使用相同角度的不同喷嘴的总分在统计学上有显著差异,并且喷嘴C的得分最高。喷嘴C具有最小羽流角度。在此模型中,三个喷嘴都不能以任何角度有效地将药物输送到中鼻道。
■喷嘴的设计影响鼻腔喷雾装置的药物输送效率。理想的给药角度是50°。具有较小羽流角度的喷嘴具有较高的药物输送效率。目前的鼻腔喷雾装置可以很容易地将药物输送到鼻腔的大部分区域,比如鼻甲,鼻中隔,嗅裂,和鼻咽部,但不是中道。这些发现对于喷嘴的选择和装置的改进是有意义的。
UNASSIGNED: Nasal sprays are widely used in treating nasal and sinus diseases; however, there are very few studies on the drug delivery efficiency of nasal sprays. In this study, the drug delivery efficiency of three different nasal spray devices was evaluated in vitro using a 3D printed cast model of nasal cavity.
UNASSIGNED: Three nasal spray devices with different nozzles and angles of administration were used in the 3D model of the nasal cavity and paranasal sinuses. The spraying area (SA), maximal spraying distance (MSD), and spraying distribution scores on the nasal septum and lateral nasal wall were recorded.
UNASSIGNED: Different nasal spray devices have their own characteristics, including volume of each spray, SA, and plume angle. The SA of the three nozzles on the nasal septum increased with an increasing angle of administration. When the angle of administration was 50°, each nozzle reached the maximal SA. There was no statistically significant difference in MSD among the three nozzles at the three angles. The total scores for each nozzle using the three different spraying angles were as follows: nozzle A, 40° > 30° > 50°; nozzle B, 30° > 40° > 50°; and nozzle C, 30° > 40° > 50°. The total scores for different nozzles using the same angle were statistically significantly different and the scores for nozzle C were the highest. Nozzle C had the minimum plume angle. None of the three nozzles could effectively delivered drugs into the middle meatus at any angle in this model.
UNASSIGNED: The design of the nozzle affects drug delivery efficiency of nasal spray devices. The ideal angle of administration is 50°. The nozzle with smaller plume angle has higher drug delivery efficiency. Current nasal spray devices can easily deliver drugs to most areas of the nasal cavity, such as the turbinate, nasal septum, olfactory fissure, and nasopharynx, but not the middle meatus. These findings are meaningful for nozzle selection and device improvements.