PDF(Pubmed)
Abstract：
Objectives: Nocturia with or without asthma is one of the aging diseases. Desmopressin has been used as a nasal spray for patients who are suffering from nocturia. This study determined the effects of desmopressin on isolated tracheal smooth muscle in vitro. Methods: We evaluated desmopressin\'s efficiency on isolated rat tracheal smooth muscle. Desmopressin was evaluated for the following effects on tracheal smooth muscle: (1) effect on resting tension; (2) effect on contraction brought on by parasympathetic mimetic 10-6 M methacholine; and (3) effect on electrically produced tracheal smooth muscle contractions. Results: As the concentration grew, desmopressin by itself had no impact on the trachea\'s baseline tension. Addition of desmopressin at doses of 10-5 M or above elicited a significant relaxation response to 10-6 M methacholine-induced contraction. Desmopressin could also inhibit spike contraction of the trachea induced by electrical field. Conclusion: According to this study, desmopressin at high quantities may prevent the trachea\'s parasympathetic activity. Due to its ability to block parasympathetic activity and lessen the contraction of the tracheal smooth muscle brought on by methacholine, Desmopressin nasal spray might help nocturia sufferers experience fewer asthma attacks.
摘要：
目的：伴有或不伴有哮喘的夜尿症是衰老疾病之一。去氨加压素已被用作患有夜尿症的患者的鼻喷雾剂。这项研究确定了去氨加压素对离体气管平滑肌的影响。方法:评价去氨加压素对离体大鼠气管平滑肌的疗效。评估去氨加压素对气管平滑肌的以下作用：（1）对静息张力的影响；（2）对副交感神经模拟物10-6M乙酰甲胆碱引起的收缩的影响；（3）对电产生的气管平滑肌收缩的影响。结果：随着浓度的增加，去氨加压素本身对气管基线张力无影响。以10-5M或以上的剂量添加去氨加压素会引起对10-6M乙酰甲胆碱诱导的收缩的显着舒张反应。去氨加压素还可以抑制电场引起的气管尖峰收缩。结论:根据本研究,大量去氨加压素可能阻止气管副交感神经活动。由于其能够阻断副交感神经活动并减轻乙酰甲胆碱引起的气管平滑肌收缩，去氨加压素鼻喷雾剂可以帮助夜尿症患者减少哮喘发作。
