■为了确定SCD中血管闭塞事件的数量是否与岩藻糖基转移酶7(FUT7)的血浆浓度有关,它催化选择素配体的合成。
■预期,分析研究。
■三级医疗保健中心的血液学和化学病理学部门。
■13-45岁的稳态HbSS个体,20例患者有3例或3例以上血管闭塞危象,前一年需要入院治疗(有或没有SCD并发症);17例其他HbSS患者有0-1例血管闭塞危象,前一年需要入院治疗,无疾病并发症。
■比较了通过ELISA测得的FUT7的稳态血浆浓度,这些患者在前一年有一次血管闭塞危象需要住院治疗,但没有疾病并发症,以及有或没有并发症的>3次危象。
■每位HbSS患者的FUT7血浆水平和血管闭塞事件的数量。
■前一年血管闭塞危象>3例患者血浆FUT7浓度均值+标准差为8.6+2.7ng/ml,0-1例危象无并发症者为7.3+1.7ng/ml;独立样本t检验,p>0.05,差异不显著。
■岩藻糖基转移酶7的血浆浓度与镰状细胞病中血管闭塞事件的数量无关。
■没有声明。
UNASSIGNED: To determine if the number of vaso-occlusive events in SCD relates to plasma concentration of fucosyltransferase 7 (FUT7), which catalyses the synthesis of selectin ligands.
UNASSIGNED: A prospective, analytical study.
UNASSIGNED: Haematology and Chemical Pathology Departments of tertiary healthcare centres.
UNASSIGNED: Steady state HbSS individuals aged 13-45 years, 20 had 3 or more vaso-occlusive crises that required hospital admission in the previous year (with or without complications of SCD); 17 other HbSS persons had 0-1 vaso-occlusive crisis that required hospital admission in the previous year and no disease complications.
UNASSIGNED: Steady-state plasma concentrations of FUT7 measured by ELISA were compared between SCD patients who had one vaso-occlusive crisis requiring hospital treatment in the previous year but no disease complications and those who had >3 crises with or without complications.
UNASSIGNED: Plasma level of FUT7and the number of vaso-occlusive events in each HbSS patient.
UNASSIGNED: Mean + standard deviation plasma concentration of FUT7 was 8.6 + 2.7 ng/ml in patients with >3 vasoocclusive crises in the previous year and 7.3 + 1.7 ng/ml in those with 0-1 crisis and no complications; independent sample t-test, p > 0.05, not significantly different.
UNASSIGNED: Plasma concentration of fucosyltransferase7 is not associated with the number of vaso-occlusive events in sickle cell disease.
UNASSIGNED: None declared.