诺如病毒是全球病毒性胃肠炎暴发的主要原因。组织血型抗原(HBGA)是诺如病毒易感性中重要的宿主附着因子。在这项研究中,FUT2基因的关联,参与HBGA的生物合成,对诺如病毒感染进行了调查。
关于FUT2基因与诺如病毒关联的所有相关研究均来自PubMed,WebofScience,Embase,和Cochrane图书馆数据库。使用几率(OR)和95%置信区间(CI)分析提取的数据。I2统计数据,敏感性分析和发表偏倚分析用于证实研究结果.对种族进行了亚组分析,基因型,国家的发展程度,出版年,记录异质性时的年龄和设置。
包括4066名参与者在内的20项研究被纳入荟萃分析。结果表明,FUT2基因与诺如病毒感染有显著相关性(OR=3.02,95CI=2.00~4.55,P<0.001)。此外,中国人诺如病毒感染的OR值(OR=4.49,95CI=2.37~8.50,P<0.001)高于白种人(OR=3.23,95CI=2.20~4.74,P<0.001)。
荟萃分析提示FUT2基因与诺如病毒感染易感性相关。
Norovirus is a leading cause of viral gastroenteritis outbreaks worldwide. Histo-blood group antigens (HBGAs) are important host attachment factors in susceptibility to norovirus. In this study, the association of FUT2 gene, which participates in the biosynthesis of HBGAs, with norovirus infection has been investigated.
All relevant studies on the associations of FUT2 gene with norovirus were retrieved from PubMed, Web of Science, Embase, and Cochrane Library databases. Odds ratios (ORs) and 95% confidence interval (CI) were used to analyze the extracted data. I2 statistic, sensitivity analysis and publication bias analysis were used to confirm the findings. Subgroup analyses were performed for races, genotypes, development degree of the countries, publication years, age and setting when heterogeneity was recorded.
Twenty studies including 4066 participants were included for the meta-analysis. This analysis showed that there is a significant association between FUT2 gene and norovirus infection (OR = 3.02, 95%CI = 2.00-4.55, P < 0.001). Additionally, the ORs of norovirus infection among Chinese (OR = 4.49, 95%CI = 2.37-8.50, P < 0.001) were higher than those among Caucasian (OR = 3.23, 95%CI = 2.20-4.74, P < 0.001).
The meta-analysis suggested that FUT2 gene is associated with susceptibility to norovirus infection.