本研究全面概述了耐药结核病研究的现状。在PubMed和Scopus数据库上进行了广泛的电子搜索,以确定与耐药结核病相关的临床试验。使用BiblioshinyApp和VOSviewer软件对数据进行网络分析和可视化。这项文献计量学研究的重点是揭示出版趋势,主要贡献者,关键机构,专题重点,和引文模式。对研究论文出版物的分析揭示了多年来一致的上升轨迹,以周期性下降和随后的激增为特征。Scopus和PubMed在2013年和2010年观察到了值得注意的峰值,分别,紧随其后的是明显的下降,在2021年至2023年之间尤其值得注意。PubMed和Scopus的数据表明,美国和南非是主要的贡献者。根据PubMed和Scopus数据库,开普敦大学和斯泰伦博斯大学是贡献最大的机构。关键词和主题分析强调了主要研究集中在耐药结核病(DR-TB),包括药物联合治疗,痰的微生物分析,抗结核药的治疗用途,耐药性(DR),多药耐药(MDR),和结核分枝杆菌.趋势主题分析揭示了研究重点随时间的动态变化,从单一药物治疗过渡到解决耐药性,并强调在耐多药结核病病例中对有效药物治疗的新需求。值得注意的是,大多数关于耐药结核病的研究论文是单一国家出版物。Scopus数据库中的引文分析表明,每年的平均引文和每年的平均总引文在2005-2006年期间达到峰值。这表明在此期间,研究界的影响力和认可度有了一段时间。这项研究的结果可能为抗击耐药结核病的战略规划提供信息,最终有助于未来加强预防,诊断,和治疗策略。
This study provides a comprehensive overview of the current landscape in drug-resistant tuberculosis research. An extensive electronic search was conducted on PubMed and Scopus databases to identify clinical trials related to drug-resistant tuberculosis. Network analysis and visualization were performed on the data using the Biblioshiny App and VOSviewer software. This bibliometric study focuses on revealing publication trends, leading contributors, key institutions, thematic focuses, and citation patterns. The analysis of research paper publications reveals a consistent upward trajectory over the years, characterized by periodic declines and subsequent surges. Noteworthy peaks in 2013 and 2010 are observed in Scopus and PubMed, respectively, followed by marked declines, particularly notable between 2021 and 2023. PubMed and Scopus data indicate that the United States and South Africa are the leading contributors. According to the PubMed and Scopus databases, the University of Cape Town and Stellenbosch University are the institutions that contribute the most. Keyword and thematic analyses underscore the primary research focuses on drug-resistant tuberculosis (DR-TB), including drug combination therapy, microbiological analysis of sputum, therapeutic uses of antitubercular agents, drug resistance (DR), multidrug resistance (MDR), and Mycobacterium tuberculosis. The trend-topic analysis reveals dynamic shifts in research focus over time, transitioning from single-drug therapy to addressing drug resistance and highlighting the emerging need for effective drug therapy in cases of multidrug-resistant tuberculosis. Notably, most research papers on drug-resistant tuberculosis are single-country publications. Citation analysis in the Scopus database indicates that the average citation per year and mean total citation per year peaked during 2005-2006. This suggests a period of heightened impact and recognition within the research community during that timeframe. The study\'s findings may inform strategic planning for combating drug-resistant tuberculosis, ultimately contributing to future enhanced prevention, diagnosis, and treatment strategies.