■布朗-麦克莱恩综合征(BMS)是一种临床疾病,其特征是周围角膜水肿具有中央角膜透明度。本研究旨在使用Pentacam®AXL和CORVISST®(OculusOptikgeräteGmbH,Wetzlar,德国)。
■介绍了BMS的三种情况。案例1涉及一名26岁的男性,案例2一个55岁的男性,病例3是一名74岁的男性。病例1和3的患者有双侧BMS,而病例2的患者右眼有BMS,左眼有无晶状体大疱性角膜病变。白内障手术后,所有三名患者均无晶状体。值得注意的是,病例1和2是一级亲属(儿子和父亲),双侧微球体无晶状体眼和儿童白内障手术产生的双侧无晶状体眼。断层扫描分析显示BMS眼睛从中心到周边的角膜厚度持续增加,以角膜厚度空间分布(CTSP)和厚度增加百分比(PTI)曲线从最薄点向周边突然上升为标志。没有平行等高线的损失,角膜的最薄点没有位移,没有证据显示角膜后表面凹陷,泛发性角膜水肿的典型征象。生物力学,BMS眼睛表现出相对正常的角膜僵硬度,综合半径,Ambrósio与水平剖面的关系厚度(ARTh),以及距角膜顶点2mm处的最大变形幅度比(DA比)。然而,病例2患者的左眼患有无晶状体大疱性角膜病变,显示生物力学参数改变,表明角膜较软,失去刚性。
■该病例系列是第一个评估带有BMS的眼睛的生物力学和断层摄影特征的病例。尽管CTSP和PTI曲线从最薄点向外围突然上升,当水肿仅限于周边时,预计这些BMS眼的中央角膜生物力学指数相对正常.当进展为中央角膜水肿并伴有大泡性角膜病变时,这些指标变得异常。
UNASSIGNED: Brown-McLean syndrome (BMS) is a clinical condition characterized by peripheral corneal edema with central corneal transparency. This study aims to document the tomographic and biomechanical characteristics of 3 patients with typical BMS features using the Pentacam® AXL and CORVIS ST® (Oculus Optikgeräte GmbH, Wetzlar, Germany).
UNASSIGNED: Three cases of BMS are presented. Case 1 involves a 26-year-old male, Case 2 a 55-year-old male, and Case 3 a 74-year-old male. The patients in Cases 1 and 3 had bilateral BMS, while the patient in Case 2 had BMS in the right eye and aphakic bullous keratopathy in the left eye. All three patients were aphakic following cataract surgery. Notably, Cases 1 and 2 were first-degree relatives (son and father), both with bilateral microspherophakia and resultant bilateral aphakia from pediatric cataract surgery. Tomographic analysis revealed a consistent increase in corneal thickness from the center to the periphery in BMS eyes, marked by an abrupt rise in the corneal thickness spatial profile (CTSP) and percentage thickness increase (PTI) curves from the thinnest point towards the periphery. There was no loss of parallel isopachs, no displacement of the thinnest point of the cornea, and no evidence of focal posterior corneal surface depression, typical signs of generalized corneal edema. Biomechanically, BMS eyes exhibited relatively normal corneal stiffness, integrated radius, Ambrósio\'s relational thickness to the horizontal profile (ARTh), and maximum deformation amplitude ratio at 2mm from the corneal apex (DA ratio). However, the left eye of the patient in Case 2, which had aphakic bullous keratopathy, showed altered biomechanical parameters indicative of a softer cornea with loss of rigidity.
UNASSIGNED: This case series is the first to evaluate the biomechanical and tomographic features of eyes with BMS. Despite the abrupt rise in CTSP and PTI curves from the thinnest point towards the periphery, the relatively normal central corneal biomechanical indices in these BMS eyes are expected when edema is limited to the periphery. These indices become abnormal when there is progression to central corneal edema with bullous keratopathy.