PDF(Pubmed)
Abstract：
The relationship between diabetes mellitus and ocular complications has been extensively studied by many authors. Diabetic keratopathy has already been well characterized and defined as a clinical entity. This review focuses on exploring corneal epithelial changes in diabetic patients, aiming to provide a pragmatic overview of the existing knowledge on this topic. The paper systematically examines alterations in corneal epithelial structure and their impact on diabetic patients. Advanced imaging techniques are also discussed for their role in precise characterization and improved diagnostics. Additionally, the paper explores the mechanisms behind corneal epithelial changes in diabetes, looking at factors such as hyperglycemia, oxidative stress, and Advanced Glycation End-Products. The impact of altered corneal epithelial integrity on barrier function and susceptibility to external issues is considered, addressing potential links to heightened proteolytic enzyme activities and delayed wound healing observed in diabetic individuals. The review also covers the practical implications of corneal epithelial changes, including the association with corneal erosions, persistent epithelial defects, and an increased risk of dry eye syndrome in diabetic patients.
摘要：
许多作者已经广泛研究了糖尿病与眼部并发症之间的关系。糖尿病性角膜病变已经被很好地表征和定义为临床实体。本文就糖尿病患者角膜上皮的改变作一综述,旨在提供有关该主题的现有知识的务实概述。本文系统地研究了角膜上皮结构的改变及其对糖尿病患者的影响。还讨论了先进的成像技术在精确表征和改进的诊断中的作用。此外,本文探讨了糖尿病角膜上皮改变背后的机制，看看高血糖等因素，氧化应激，和高级糖基化终产物。考虑了角膜上皮完整性改变对屏障功能和外部问题易感性的影响，解决了在糖尿病个体中观察到的与蛋白水解酶活性增强和伤口愈合延迟的潜在联系。该综述还涵盖了角膜上皮变化的实际意义，包括角膜糜烂，持续性上皮缺损,糖尿病患者干眼综合征的风险增加。
