在这项研究中,我们的目的是评估冠心病(CHD)的严重程度与随后的眼睑炎严重程度之间的相关性.这项基于人群的回顾性队列研究是使用台湾国家健康保险研究数据库(NHIRD)进行的。有CHD诊断的参与者以1:2的比例分为轻度CHD和重度CHD组。根据是否进行经皮冠状动脉介入治疗(PCI)。主要结果是应用抗生素后发展为眼睑炎和严重眼睑炎。进行Cox比例风险回归以获得眼睑炎的校正风险比(aHR),组间置信区间(CI)为95%。在轻度和重度CHD组中,有22,161和15,369例眼睑炎事件,以及9597和4500例严重眼睑炎发作。分别。严重CHD组表现出明显更高的眼睑炎发展发生率(aHR,1.275;95%CI:1.051-1.912,p=0.0285),而严重眼睑炎的发生率在两组之间没有显着差异(aHR,0.981;95%CI:0.945-1.020,p=0.3453)。重度CHD组发生睑缘炎的累积概率明显高于轻度CHD组(p<0.001)。在亚组分析中,与年轻组相比,70岁以上患者的重度CHD与眼睑炎之间的相关性更为显著(p=0.0115).总之,严重的CHD比轻度CHD有更高的眼睑炎发病率,这种相关性在70岁以上的人中更为突出。
In this study, we aimed to evaluate the association between the severity of coronary heart disease (CHD) and the subsequent severity of
blepharitis. This retrospective population-based cohort study was conducted using the National Health Insurance Research Database (NHIRD) of Taiwan. The participants with a CHD diagnosis were divided into mild CHD and severe CHD groups at a 1:2 ratio, according to whether percutaneous coronary intervention (PCI) was performed. The main outcomes were the development of
blepharitis and severe
blepharitis with the application of antibiotics. Cox proportional hazard regression was performed to obtain the adjusted hazard ratio (aHR) for blepharitis, with a 95% confidence interval (CI) between the groups. There were 22,161 and 15,369
blepharitis events plus 9597 and 4500 severe
blepharitis episodes in the mild and severe CHD groups, respectively. The severe CHD group showed a significantly higher incidence of
blepharitis development (aHR, 1.275; 95% CI: 1.051-1.912, p = 0.0285), whereas the incidence of severe blepharitis was not significantly different between the groups (aHR, 0.981; 95% CI: 0.945-1.020, p = 0.3453). The cumulative probability of blepharitis was significantly higher in the severe CHD group than in the mild CHD group (p < 0.001). In the subgroup analyses, the correlation between severe CHD and
blepharitis was more significant in patients older than 70 years compared to the younger group (p = 0.0115). In conclusion, severe CHD is associated with a higher incidence of blepharitis than mild CHD, and this correlation is more prominent in individuals older than 70 years.