目的:评估1%阿奇霉素滴眼液(AZM)对细菌性睑板腺功能障碍(MGD)患者的疗效。
方法:多中心,单臂,前瞻性干预研究。
方法:在前2天每天两次向受影响的眼睛施用AZM,在随后的12天每天一次。叶缘充血/发红,睫毛根部的香烟,结膜充血,异物感,在第1天,第14天和第28天对其进行评估。干眼相关生活质量评分(DEQS)和MGD相关目标,包括眼睑血管,眼睑边缘不规则,发泡,盖子堵塞,角膜结膜疾病,马克思路线,美布等级,和眼泪分手的时间,也进行了评估。在第1天和第14天进行结膜囊和睑油的细菌培养。
结果:24例患者(10例男性/14例女性,包括平均年龄72.3±13.2)。在第14天和第28天,总分,眼睑血管,盖子堵塞,和meibum等级显着改善(p<0.05)。在第1天,从24只眼中的22只分离出71株菌株(91.7%)。粉刺杆菌,棒状杆菌属。,和葡萄球菌的检测频率很高。治疗结束时结膜囊和睑膜中细菌的总体消失率分别为65.7%和58.3%,分别。没有观察到严重的眼部或全身不良事件。
结论:AZM治疗14天对伴有MGD的眼睑炎患者有效,治疗后AZM的疗效持续一段时间。
OBJECTIVE: To assess the effects of 1% azithromycin ophthalmic solution (AZM) in patients with bacterial
blepharitis accompanied by meibomian gland dysfunction (MGD).
METHODS: A multicenter, single arm, prospective interventional study.
METHODS: AZM was administered to the affected eyes twice daily for the first 2 days and once daily for the subsequent 12 days. Lid margin hyperaemia/redness, collarette at the root of the eyelashes, conjunctival hyperaemia, foreign body sensation, and epiphora were assessed on Days 1, 14, and 28. The Dry Eye-related Quality of Life Score (DEQS) and objectives related to MGD, including lid vascularity, lid margin irregularity, foaming, lid plugging, keratoconjunctival disorders, Marx line, meibum grade, and tear breakup time, were also assessed. Bacterial culture of the conjunctival sac and meibum was performed on Days 1 and 14.
RESULTS: Twenty-four eyes of 24 patients (10 men/14 women, mean age 72.3 ± 13.2) were included. On Days 14 and 28, the total score, lid vascularity, lid plugging, and meibum grade showed significant improvement (p < 0.05). On Day 1, 71 strains were isolated from 22 of the 24 eyes (91.7%). Cutibacterium acnes, Corynebacterium spp., and Staphylococci were detected at high frequencies. The overall disappearance rates of the bacteria in the conjunctival sac and meibum at the end of treatment were 65.7% and 58.3%, respectively. No serious ocular or systemic adverse events were observed.
CONCLUSIONS: Fourteen-day treatment with AZM was effective in patients with
blepharitis accompanied by MGD, and the efficacy of AZM persisted for a period after the treatment.