PDF(Pubmed)
Abstract：
The treatment and management of ocular surface diseases have shifted towards a co-treatment approach focusing on overall ocular surface homeostasis. When treating issues related to the eye, it is essential to not only focus on the damaged or disabled areas but also consider the larger picture. Meibomian gland dysfunction (MGD), Demodex infection, and blepharitis all interact at the eyelid site and can cause damage to the ocular surface to varying degrees. Palpebral lesions disrupt the balance of ocular surface homeostasis, leading to dry eye and keratitis. Traditional treatments, such as manual physical hot compress massage, have limited effectiveness due to the structure of the eyelid. However, intense pulsed light (IPL) technology uses penetrating light energy to generate heat energy, which can eliminate inflammation of capillaries or kill Demodex. Additionally, the LipiFlow thermal effect and physical compression provide a more vital and longer-lasting therapeutic effect on MGD by excluding other primary causes of ocular surface inflammation. Therefore, personalized treatment techniques based on photothermal effects may be effective. In the future, IPL and LipiFlow may potentially dismiss immune-inflammation factors causing ocular surface disease or block the delivery of systemic immune-related diseases.
摘要：
眼表疾病的治疗和管理已转向专注于整体眼表稳态的联合治疗方法。在治疗与眼睛有关的问题时，不仅要关注受损或残疾地区，还要考虑更大的图景。睑板腺功能障碍(MGD),蠕形螨感染，和眼睑炎都在眼睑部位相互作用，并可能对眼表造成不同程度的损害。眼睑病变破坏眼表稳态的平衡，导致干眼症和角膜炎。传统治疗,如手动物理热敷按摩，由于眼睑的结构，效果有限。然而,强脉冲光（IPL）技术利用穿透光能产生热能，可以消除毛细血管炎症或杀死蠕形螨。此外,LipiFlow热效应和物理压迫通过排除眼表炎症的其他主要原因，对MGD提供了更重要和更持久的治疗效果。因此,基于光热效应的个性化治疗技术可能是有效的。在未来,IPL和LipiFlow可能会消除引起眼表疾病的免疫炎症因子或阻断全身性免疫相关疾病的传递。
