■哮喘和过敏性鼻炎(AR)可以共存并导致残疾。本研究旨在评估AR,哮喘控制,哮喘相关的生活质量,和其他合并症。
■一项横断面研究是在泰国六家医院的成人哮喘患者中进行的。结果是通过哮喘控制测试(ACT)评估的哮喘控制关联,AR,和哮喘合并症。未良好控制的哮喘定义为ACT评分≤22。AR的严重程度通过视觉模拟量表(VAS)确定。重度AR定义为VAS≥5。哮喘相关生活质量(AQLQ),合并症,并记录总IgE。
■共纳入682名哮喘患者。中位年龄(IQR)为58.0(47.0-64.0)岁。69.9%为女性。44.7%的哮喘控制不佳。AR的患病率为86.1%。21.7%的患者诊断为中度/重度持续性AR,30.2%的患者诊断为重度AR。97.7%的患者服用了含皮质类固醇的吸入方案。鼻内皮质类固醇和抗组胺药分别为65.7%和31.7%,分别。哮喘控制不佳的患者体重指数较高,VAS评分,污染暴露的比例,空气过敏原致敏,严重AR,鼻息肉,荨麻疹,食物过敏,胃食管反流病,抑郁和焦虑,消化性溃疡,和哮喘恶化,但是年龄更小,较低的AQLQ分数,更低的FEV1。AR严重程度与ACT之间存在相关性(r=-0.461,p<0.001),AQLQ(r=-0.512,p<0.001),和总IgE(r=0.246,p<0.023)。多元回归分析显示,ACT,AQLQ,FEV1/FVC的百分比与严重AR显著相关。
■过敏性鼻炎在泰国哮喘患者中普遍存在。AR严重程度与哮喘控制有关,生活质量,和肺功能。全面的护理对于未控制的哮喘患者至关重要,特别是与条件共存时。
UNASSIGNED: Asthma and allergic rhinitis (AR) can coexist and cause disabilities. This study aimed to assess the association between AR, asthma control, asthma-related quality of life, and other comorbidities.
UNASSIGNED: A cross-sectional study was conducted in adults with asthma in six hospitals in Thailand. The outcomes were association of asthma control assessed by the asthma control test (
ACT), AR, and asthma comorbidities. Not-well-controlled asthma was defined as
ACT scores ≤22. The severity of AR was determined by visual analog scale (VAS). Severe AR was defined as VAS ≥5. Asthma-related quality of life (AQLQ), comorbidities, and total IgE were recorded.
UNASSIGNED: A total of 682 asthmatic patients were included. Median (IQR) age was 58.0 (47.0-64.0) years. 69.9% were female. Not-well-controlled asthma was present in 44.7%. The prevalence of AR was 86.1%. Moderate/severe persistent AR was diagnosed in 21.7% and severe AR was diagnosed in 30.2% of the patients. Inhaled corticosteroid-containing regimens were prescribed in 97.7% of patients. Intranasal corticosteroid and antihistamine were prescribed in 65.7 and 31.7%, respectively. Patients with not-well-controlled asthma had higher body mass index, VAS scores, proportions of pollution exposure, aeroallergen sensitization, severe AR, nasal polyp, urticaria, food allergy, gastroesophageal reflux disease, depression and anxiety, peptic ulcer, and asthma exacerbations, but younger age, lower AQLQ scores, and lower FEV1. Correlation was found between AR severity and
ACT (r = -0.461, p < 0.001), AQLQ (r = -0.512, p < 0.001), and total IgE (r = 0.246, p < 0.023). Multiple regression analysis revealed that
ACT, AQLQ, and percentage of FEV1/FVC were significantly associated with severe AR.
UNASSIGNED: Allergic rhinitis is prevalent in Thai asthmatic patients. AR severity is associated with asthma control, quality of life, and pulmonary function. Comprehensive care is essential for patients with uncontrolled asthma, particularly when coexisting with conditions.