PDF(Pubmed)
Abstract：
Malaria poses a global threat to human health, with millions of cases and thousands of deaths each year, mainly affecting developing countries in tropical and subtropical regions. Malaria\'s causative agent is Plasmodium species, generally transmitted in the hematophagous act of female Anopheles sp. mosquitoes. The main approaches to fighting malaria are eliminating the parasite through drug treatments and preventing transmission with vector control. However, vector and parasite resistance to current strategies set a challenge. In response to the loss of drug efficacy and the environmental impact of pesticides, the focus shifted to the search for biocompatible products that could be antimalarial. Plant derivatives have a millennial application in traditional medicine, including the treatment of malaria, and show toxic effects towards the parasite and the mosquito, aside from being accessible and affordable. Its disadvantage lies in the type of administration because green chemical compounds rapidly degrade. The nanoformulation of these compounds can improve bioavailability, solubility, and efficacy. Thus, the nanotechnology-based development of plant products represents a relevant tool in the fight against malaria. We aim to review the effects of nanoparticles synthesized with plant extracts on Anopheles and Plasmodium while outlining the nanotechnology green synthesis and current malaria prevention strategies.
摘要：
疟疾对人类健康构成全球威胁，每年有数百万例病例和数千人死亡，主要影响热带和亚热带地区的发展中国家。疟疾的病原体是疟原虫，通常在雌性按蚊的吸血行为中传播。蚊子。抗击疟疾的主要方法是通过药物治疗消除寄生虫，并通过病媒控制预防传播。然而,媒介和寄生虫对当前策略的抵抗力提出了挑战。针对药效丧失和农药对环境的影响,重点转移到了寻找生物相容性抗疟药物.植物衍生物在传统医学中有着千禧年的应用，包括治疗疟疾，对寄生虫和蚊子有毒性作用，除了可获得和负担得起。它的缺点在于给药的类型，因为绿色化合物会迅速降解。这些化合物的纳米制剂可以提高生物利用度，溶解度，和功效。因此，基于纳米技术的植物产品开发代表了抗击疟疾的相关工具。我们旨在回顾用植物提取物合成的纳米颗粒对按蚊和疟原虫的影响，同时概述纳米技术绿色合成和当前的疟疾预防策略。
