虽然许多可注射的粘胶补充剂产品可用于骨关节炎(OA)管理,可进一步优化多种水凝胶功能属性以增强功效。这项研究的目的是在功能上对四种市售的基于透明质酸的粘胶补充剂(Ostenil,OstenilPlus,Synvisc,和Innoryos),专注于关键(流变学,润滑,粘合剂,和稳定性)属性。因此,体外和离体定量表征面板(振荡流变学,旋转摩擦学,和具有牛软骨的质地分析)用于水凝胶产品功能基准测试,使用马滑液作为生物对照。具体来说,保留的实验方法使作者能够稳健地评估和讨论基于透明质酸水凝胶的各种功能增强方案(化学交联和添加抗氧化剂稳定剂).结果表明,Innoryos产品,一种烟酰胺增强的线性透明质酸水凝胶,在保留的实验设置中表现出最佳的整体功能行为(高粘附性和润滑性以及对氧化降解的实质性抵抗力)。相反,与其他研究的产品相比,Ostenil产品显示出不太期望的用于增粘补充的功能性质。一般来说,这项研究证实了配方开发和控制方法优化的高度重要性,旨在增强新型OA靶向产品的关键功能属性及其临床成功的可能性。总的来说,这项工作证实了对基于透明质酸的粘性补充剂产品功能基准(骨科医生的产品开发和产品选择)的综合方法的切实需求,以最大限度地提高有效的临床OA管理的机会.
While many injectable viscosupplementation products are available for osteoarthritis (OA) management, multiple hydrogel functional attributes may be further optimized for efficacy enhancement. The objective of this study was to functionally benchmark four commercially available hyaluronan-based viscosupplements (Ostenil, Ostenil Plus, Synvisc, and Innoryos), focusing on critical (rheological, lubricative, adhesive, and stability) attributes. Therefore, in vitro and ex vivo quantitative characterization panels (oscillatory rheology, rotational
tribology, and texture analysis with bovine cartilage) were used for hydrogel product functional benchmarking, using equine synovial fluid as a biological control. Specifically, the retained experimental methodology enabled the authors to robustly assess and discuss various functional enhancement options for hyaluronan-based hydrogels (chemical cross-linking and addition of antioxidant stabilizing agents). The results showed that the Innoryos product, a niacinamide-augmented linear hyaluronan-based hydrogel, presented the best overall functional behavior in the retained experimental settings (high adhesivity and lubricity and substantial resistance to oxidative degradation). The Ostenil product was conversely shown to present less desirable functional properties for viscosupplementation compared to the other investigated products. Generally, this study confirmed the high importance of formulation development and control methodology optimization, aiming for the enhancement of novel OA-targeting product critical functional attributes and the probability of their clinical success. Overall, this work confirmed the tangible need for a comprehensive approach to hyaluronan-based viscosupplementation product functional benchmarking (product development and product selection by orthopedists) to maximize the chances of effective clinical OA management.