longitudinal design

纵向设计
  • 文章类型: Journal Article
    背景:淀粉样蛋白阳性(Aβ)个体的主观认知功能下降(SCD)被认为是阿尔茨海默病(AD)连续体2期的临床指标,但这需要跨文化的进一步验证,措施,和招聘策略。
    方法:来自SILCODE和DELCODE队列的8121名参与者,包括正常对照(NC)和从社区或记忆诊所招募的SCD患者,接受了长达6年的神经心理学评估。淀粉样蛋白阳性来自正电子发射断层扫描或血浆生物标志物。使用线性混合效应模型分析了全球认知变化。
    结果:在合并和分层的队列中,与患有SCD的NC或Aβ参与者相比,患有SCD的Aβ参与者显示出更陡的认知下降或实践效果减弱。使用SCD和淀粉样蛋白阳性的不同操作证实了这些发现,以及不同的SCD招募设置。
    结论:德国和中国人群中的Aβ+SCD患者表现出更大的全球认知能力下降,可以作为干预试验的目标。
    结论:淀粉样蛋白阳性(Aβ+)参与者的SCD预示着更严重的认知功能下降。该发现不依赖于特定的SCD或淀粉样蛋白操作。这一发现并非特定于从记忆诊所招募的SCD患者。这一发现在德国和中国人群中都是有效的。Aβ+患有SCD的老年人可能是介入试验的目标人群。
    BACKGROUND: Subjective cognitive decline (SCD) in amyloid-positive (Aβ+) individuals was proposed as a clinical indicator of Stage 2 in the Alzheimer\'s disease (AD) continuum, but this requires further validation across cultures, measures, and recruitment strategies.
    METHODS: Eight hundred twenty-one participants from SILCODE and DELCODE cohorts, including normal controls (NC) and individuals with SCD recruited from the community or from memory clinics, underwent neuropsychological assessments over up to 6 years. Amyloid positivity was derived from positron emission tomography or plasma biomarkers. Global cognitive change was analyzed using linear mixed-effects models.
    RESULTS: In the combined and stratified cohorts, Aβ+ participants with SCD showed steeper cognitive decline or diminished practice effects compared with NC or Aβ- participants with SCD. These findings were confirmed using different operationalizations of SCD and amyloid positivity, and across different SCD recruitment settings.
    CONCLUSIONS: Aβ+ individuals with SCD in German and Chinese populations showed greater global cognitive decline and could be targeted for interventional trials.
    CONCLUSIONS: SCD in amyloid-positive (Aβ+) participants predicts a steeper cognitive decline. This finding does not rely on specific SCD or amyloid operationalization. This finding is not specific to SCD patients recruited from memory clinics. This finding is valid in both German and Chinese populations. Aβ+ older adults with SCD could be a target population for interventional trials.
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  • 文章类型: Journal Article
    COVID-19大流行对人们的人际关系和心理健康产生了持久的影响。利用中国的四波数据(N=222,女性占54.50%,法师=31.53,SD=8.17),本研究通过大流行中期感知的社会支持和/或感恩,调查了大流行前关系满意度是否与大流行后COVID-19焦虑相关.结果表明,人群的COVID-19焦虑从流行的高峰到低谷阶段下降;感知的社会支持从流行到高峰显著增加,随后保持稳定。而关系满意度始终保持不变。Further,这是中期大流行感知的社会支持,不是感恩,这介导了流行前关系满意度和流行后COVID-19焦虑之间的关系,这表明感知的社会支持在这一过程中发挥了至关重要的作用。最后,建议将感知的社会支持与感恩区分为社会互动的两个不同组成部分。
    The COVID-19 pandemic has had lasting impacts on people\'s interpersonal relationship and mental health. Using four-wave data in China (N = 222, 54.50% female, Mage = 31.53, SD = 8.17), the current study examined whether prepandemic relationship satisfaction was related to postpandemic COVID-19 anxiety through midpandemic perceived social support and/or gratitude. The results showed that people\'s COVID-19 anxiety decreased from the peak to the trough stage of the pandemic; perceived social support increased markedly from prepandemic to the peak and remained stable subsequently, while relationship satisfaction remained unchanged throughout. Further, it was midpandemic perceived social support, not gratitude, that mediated the association between prepandemic relationship satisfaction and postpandemic COVID-19 anxiety, indicating that perceived social support played a crucial role in this process. Finally, it is suggested that perceived social support should be distinguished from gratitude as two different components of social interactions.
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  • 文章类型: Journal Article
    这项研究探讨了产前应激之间的相互作用,儿童性,注意缺陷/多动障碍(ADHD)的多基因风险评分(PGS)与ADHD相关的大脑区域的结构发育变化有关。我们使用了来自两个基于人口的出生队列的数据:在新加坡长大,来自新加坡的健康结果(GUSTO)(n=113)和来自鹿特丹的R代,荷兰(n=433)。使用问卷评估产前压力。我们使用验证性因素分析获得了产前逆境和产前情绪问题的潜在结构。参与者使用全基因组单核苷酸多态性阵列进行基因分型,和ADHDPGSs进行计算。磁共振成像扫描在4.5年和6年(GUSTO),10岁和14岁(R代)。我们估计与ADHD相关的大脑结局的年龄相关变化率,并通过性别互动模型进行(1)产前应激,(2)产前应激采用ADHDPGS交互作用模型,和(3)三向交互模型,包括产前压力,性别,和多动症PGS。我们观察到产前应激和ADHDPGS对R代平均皮质厚度年变化率的相互作用(即,在多动症PGS较高的个体中,较高的产前应激与较低的皮质变薄率相关,而在多动症PGS较低的个体中,较高的产前应激与较高的皮质变薄率相关)。其他测试的相互作用均无统计学意义。在ADHD遗传脆弱性较高的个体中,较高的产前压力可能会促进青春期大脑发育速度较慢,而在ADHD遗传脆弱性较低的个体中,它可能会促进更快的大脑发育速度。
    This study explored the interactions among prenatal stress, child sex, and polygenic risk scores (PGS) for attention-deficit/hyperactivity disorder (ADHD) on structural developmental changes of brain regions implicated in ADHD. We used data from two population-based birth cohorts: Growing Up in Singapore Towards healthy Outcomes (GUSTO) from Singapore (n = 113) and Generation R from Rotterdam, the Netherlands (n = 433). Prenatal stress was assessed using questionnaires. We obtained latent constructs of prenatal adversity and prenatal mood problems using confirmatory factor analyses. The participants were genotyped using genome-wide single nucleotide polymorphism arrays, and ADHD PGSs were computed. Magnetic resonance imaging scans were acquired at 4.5 and 6 years (GUSTO), and at 10 and 14 years (Generation R). We estimated the age-related rate of change for brain outcomes related to ADHD and performed (1) prenatal stress by sex interaction models, (2) prenatal stress by ADHD PGS interaction models, and (3) 3-way interaction models, including prenatal stress, sex, and ADHD PGS. We observed an interaction between prenatal stress and ADHD PGS on mean cortical thickness annual rate of change in Generation R (i.e., in individuals with higher ADHD PGS, higher prenatal stress was associated with a lower rate of cortical thinning, whereas in individuals with lower ADHD PGS, higher prenatal stress was associated with a higher rate of cortical thinning). None of the other tested interactions were statistically significant. Higher prenatal stress may promote a slower brain developmental rate during adolescence in individuals with higher ADHD genetic vulnerability, whereas it may promote a faster brain developmental rate in individuals with lower ADHD genetic vulnerability.
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  • 文章类型: Journal Article
    这项研究旨在基于工作需求-资源模型,证明工作中的无聊和工作投入与其潜在的前因(工作需求和工作资源)和后果(心理困扰和离职意向)有关的经验独特性。在日本一家互联网调查公司的注册监测员中进行了三波纵向调查。问卷包括工作中无聊的量表,工作参与,心理困扰,和离职意向以及参与者的工作特征和人口统计学变量。通过结构方程模型对1,019名全职工作的参与者进行了假设模型评估。不出所料,工作中的无聊与定量工作需求和工作资源呈负相关,与心理困扰和离职倾向呈正相关。相比之下,工作投入与工作资源呈正相关,与离职倾向呈负相关。因此,工作中的无聊和工作投入具有不同的潜在前因,并且与员工幸福感和组织成果成反比。然而,与预期相反,定性工作需求与工作中的无聊感没有显著相关.需要进一步调查以了解无聊和定性工作需求之间的关系,这需要持续的认知负荷和使用更高的技能。
    This study aimed to demonstrate the empirical distinctiveness of boredom at work and work engagement in relation to their potential antecedents (job demands and job resources) and consequences (psychological distress and turnover intention) based on the Job Demands-Resources model. A three-wave longitudinal survey was conducted among registered monitors of an Internet survey company in Japan. The questionnaire included scales for boredom at work, work engagement, psychological distress, and turnover intention as well as participants\' job characteristics and demographic variables. The hypothesized model was evaluated via structural equation modeling with 1,019 participants who were employed full-time. As expected, boredom at work was negatively associated with quantitative job demands and job resources and positively associated with psychological distress and turnover intention. In contrast, work engagement was positively associated with job resources and negatively associated with turnover intention. Thus, boredom at work and work engagement had different potential antecedents and were inversely related to employee well-being and organizational outcomes. However, contrary to expectations, qualitative job demands were not significantly associated with boredom at work. Further investigation is needed to understand the relationship between boredom and qualitative job demands, which require sustained cognitive load and the use of higher skills.
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  • 文章类型: Journal Article
    目的:该研究旨在初步评估感知压力量表(PSS-C-10)的10项简体中文版的测量特性,评估纵向测量不变性(LMI)。
    方法:使用PSS-C-10对方便的医疗保健学生进行了纵向调查。我们主要使用复合分析方法评估PSS-C-10,包括探索性图分析(EGA)和验证性因子分析(CFA),以建议最佳拟合因子结构并评估测量不变性。
    结果:EGA确定了一种双因素结构解决方案,基线时的准确度为98.6%,7天随访时的准确度为100%。CFA随后证实了这种结构,基线时的比较拟合指数为0.963,随访时的比较拟合指数为0.987,基线时塔克-刘易斯指数为0.951,随访时为0.982,基线时的均方根误差为0.111,随访时的均方根误差为0.089。LMI得到了拟合优度指数的支持,它们的变化落在建议的截止范围内。此外,Cronbachα(基线为0.885,随访为0.904),麦当劳的欧米茄(基线为0.885,随访为0.902),7天的ICC值为0.816,证明了PSS-C-10的可靠可靠性。
    结论:PSS-C-10表现出稳定的双因素结构,具有有希望的LMI和测量性能。
    The study aimed to initially assess the measurement properties of the 10-item simplified Chinese version of the Perceived Stress Scale (PSS-C-10) and as a first, assess a longitudinal measurement invariance (LMI).
    A longitudinal survey was conducted with a convenient sample of healthcare students using the PSS-C-10. We assessed the PSS-C-10 mainly using composite analytical approaches, including exploratory graph analysis (EGA) and confirmatory factor analysis (CFA) to suggest the best-fit factor structure and assess measurement invariance.
    The EGA identified a two-factor structural solution with an accuracy of 98.6% at baseline and 100% at a 7-day follow-up. The CFA subsequently confirmed this structure, with a comparative fit index of 0.963 at baseline and 0.987 at follow-up, Tucker-Lewis index of 0.951 at baseline and 0.982 at follow-up, and root mean square error of approximation of 0.111 at baseline and 0.089 at follow-up. The LMI was supported by the goodness-of-fit indices, and their changes fell within the recommended cut-off range. Additionally, Cronbach\'s alpha (0.885 at baseline and 0.904 at follow-up), McDonald\'s omega (0.885 at baseline and 0.902 at follow-up), and an ICC value of 0.816 for 7 days demonstrated the robust reliability of the PSS-C-10.
    The PSS-C-10 exhibited a stable two-factor structure with promising LMI and measurement properties.
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  • 文章类型: Journal Article
    自我控制和自我真实性对个体的心理健康和社会适应都至关重要,但是他们的关系很少受到关注。研究表明,施加自我控制可以帮助个人实现真实的自我,并且可以通过感知真实性来促进。因此,这项研究采用了纵向设计,并在2,982名中国青少年的大样本中调查了自我控制与自我真实性之间的时间关系(Mage=17.53,SD=0.84)。相关分析显示,自我控制力较高的参与者具有较高的自我真实性。交叉滞后路径分析显示,随着时间的推移,自我控制与自我真实性之间存在着相互关系。此外,双变量潜在变化得分模型表明,自我控制预测自我真实性随时间的增加,反之亦然。总的来说,这项研究促进了我们的理解,并表明抑制诱惑和冲动可以促进青少年的真实性,以及真实性的体验,反过来,促进他们的自我调节。
    Both self-control and self-authenticity are critical to individuals\' mental health and social adjustment, but their relationship has received little attention. Research demonstrates that exerting self-control could help individuals achieve true self and might be promoted by perceiving authenticity. Accordingly, this study utilized a longitudinal design and investigated the temporal relationship between self-control and self-authenticity in a large sample of 2,982 Chinese adolescents (Mage = 17.53, SD = 0.84). Correlation analysis showed that participants possessing higher self-control were associated with greater self-authenticity. Cross-lagged path analysis revealed a reciprocal relationship between self-control and self-authenticity over time. Moreover, bivariate latent change score model indicated that self-control predicted an increase in self-authenticity across time, and vice versa. Overall, this study advances our understanding and suggests that restraining temptation and impulse can promote adolescents\' authenticity, and that the experience of authenticity, in turn, facilitates their self-regulation.
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  • 文章类型: Journal Article
    背景:有记录表明,在COVID-19大流行期间,卫生专业人员的职业压力水平增加。尽管对服务的需求增加,但很少有研究检查大流行对精神卫生专业人员的影响。
    方法:多语言,纵向,世卫组织全球临床实践网络(GCPN)成员在大流行期间的三个时间点进行了全球调查。来自86个国家的786名GCPN成员对评估职业困扰的调查做出了回应,健康和创伤后压力症状。
    结果:平均而言,受访者的幸福感随着时间的推移而恶化,而他们的创伤后应激症状显示出适度的改善。线性生长模型表明,作为女性,更年轻,为COVID-19患者提供面对面的医疗服务,生活在低收入或中等收入国家或COVID-19死亡率较高的国家,随着时间的推移,幸福感差和压力症状水平较高的风险更大。增长混合模型确定了职业幸福感和压力症状的轨迹。大多数心理健康职业对幸福感没有影响,保持适度,非临床水平的压力症状,或在最初的困难时期后表现出改善。然而,一些参与者组表现出健康状况恶化,接近临床阈值(25.8%),并且随着时间的推移,创伤后应激症状持续较高水平和具有临床意义的水平(19.6%).
    结论:这项研究表明,尽管大多数心理健康专业人员在大流行期间表现出稳定的积极幸福感和低压力症状,在大流行期间,已经负担沉重的全球精神卫生工作人员中,有相当一部分人的心理状况持续恶化或恶化。
    Increased levels of occupational stress among health professionals during the COVID-19 pandemic have been documented. Few studies have examined the effects of the pandemic on mental health professionals despite the heightened demand for their services.
    A multilingual, longitudinal, global survey was conducted at 3 time points during the pandemic among members of the World Health Organization\'s Global Clinical Practice Network. A total of 786 Global Clinical Practice Network members from 86 countries responded to surveys assessing occupational distress, well-being, and posttraumatic stress symptoms.
    On average, respondents\' well-being deteriorated across time while their posttraumatic stress symptoms showed a modest improvement. Linear growth models indicated that being female, being younger, providing face-to-face health services to patients with COVID-19, having been a target of COVID-related violence, and living in a low- or middle-income country or a country with a higher COVID-19 death rate conveyed greater risk for poor well-being and higher level of stress symptoms over time. Growth mixed modeling identified trajectories of occupational well-being and stress symptoms. Most mental health professions demonstrated no impact to well-being; maintained moderate, nonclinical levels of stress symptoms; or showed improvements after an initial period of difficulty. However, some participant groups exhibited deteriorating well-being approaching the clinical threshold (25.8%) and persistently high and clinically significant levels of posttraumatic stress symptoms (19.6%) over time.
    This study indicates that although most mental health professionals exhibited stable, positive well-being and low stress symptoms during the pandemic, a substantial minority of an already burdened global mental health workforce experienced persistently poor or deteriorating psychological status over the course of the pandemic.
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  • 文章类型: Journal Article
    背景:近年来,非自杀性自我伤害(NSSI)引起了越来越多的关注,网络受害(CV)已被确定为青少年NSSI的危险因素。然而,对这种关联的纵向中介和调节机制知之甚少。在经验回避模型的指导下,本研究采用简短的纵向设计来研究抑郁症状的中介作用以及CV和NSSI之间情绪反应性的调节作用.
    方法:共有577名中国中学生(Mage=14.38,SD=0.67)完成了CV的测量,NSSI,抑郁症状,和情绪反应性。他们提供了两个波(T1和T2,相隔6个月)的数据。
    结果:结果发现CV和NSSI之间存在纵向关联以及抑郁症状的中介作用。此外,情绪反应性通过抑郁症状放大了CV和NSSI之间的关系;特别是,抑郁症状与NSSI之间的关系仅在情绪反应性高的青少年中显著.
    结论:目前的研究发现,情绪反应性调节了抑郁症状对CV和NSSI之间关系的间接影响。这些发现对青少年早期NSSI的识别和干预具有重要意义。
    Nonsuicidal self-injury (NSSI) has garnered growing attention in recent years, and cybervictimization (CV) has been identified as a risk factor for NSSI among adolescents. However, little is known about this association\'s longitudinal mediating and moderating mechanisms. Guided by the experiential avoidance model, the present study used a short longitudinal design to examine the mediating role of depressive symptoms and the moderating role of emotional reactivity between CV and NSSI.
    A total of 577 Chinese middle school students (Mage  = 14.38, SD = 0.67) completed the measures of CV, NSSI, depressive symptoms, and emotional reactivity. They provided data in two waves (T1 and T2, 6 months apart).
    The results found a longitudinal association between CV and NSSI as well as the mediating role of depressive symptoms. Moreover, emotional reactivity amplified the relationship between CV and NSSI via depressive symptoms; specifically, the relationship between depressive symptoms and NSSI was only significant for adolescents with high emotional reactivity.
    The current study has found that emotional reactivity moderated the indirect effect of depressive symptoms on the relationship between CV and NSSI. These findings have implications for the identification and intervention of NSSI in early adolescents.
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  • 文章类型: Journal Article
    This study investigates the longer-term effects of parental migration on the psychological well-being of children who stay behind in two major labor-sending countries in Southeast Asia, namely, Indonesia and the Philippines. Adopting the framework of the \'care triangle\', we further examine how caregivers\' mental health and caregiving quality moderate the associations between parental migration and children\'s psychological well-being.
    Using longitudinal data collected in 2008 and 2016/17, we assess children\'s psychological well-being during early childhood (aged 3-5 years) and again in adolescence (aged 11-13 years). We apply both fixed-effects and random-effects models, using the Hausman test to indicate the preferred model.
    The findings indicate that there is no significant longer-term effect of parental migration on children\'s psychological well-being, but parental migration tends to show adverse effects on Filipino children\'s psychological well-being when they are cared for by a caregiver with poor mental health.
    The two-country comparison demonstrates the complexities of understanding the gender-based influences of parental migration on children\'s psychological well-being. The findings also highlight the caregiver\'s role in maintaining frequent communications with migrant parents within the care triangle, which is crucial to children\'s well-being.
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  • 文章类型: Journal Article
    背景:先前的研究表明,工作记忆(WM)更新和WM容量在数学能力中起着至关重要的作用。然而,目前还不清楚WM能力是否介导WM更新对数学的影响,以及级联效应是否随不同的数学领域而变化。
    目的:本研究旨在探讨WM能力在WM更新与数学性能之间的纵向中介作用,以及关系如何随着年龄和领域而变化。
    方法:共有131名中国一年级学生参加了这项研究。
    方法:要求参与者完成一年级和二年级WM更新和WM能力的任务,以及三年级数学成绩的纸笔测试。研究了WM更新和能力在学生数学成绩发展中的作用。
    结果:结果表明,1年级的言语WM更新通过其对2年级的言语WM能力的级联效应来预测3年级的基本算术和逻辑视觉空间能力。此外,1年级的视觉空间WM更新预测了2年级的视觉空间WM容量。1年级的视觉空间WM能力预测了3年级的逻辑视觉空间能力,而不是3年级的基本算术能力。
    结论:研究结果表明,WM更新通过WM能力对瞳孔的数学表现产生影响,同时,这种效果取决于儿童的数学领域。
    BACKGROUND: Previous studies indicated that working memory (WM) updating and WM capacity play essential roles in mathematical ability. However, it is unclear whether WM capacity mediates the effect of WM updating on mathematics, and whether the cascading effects vary with different mathematical domains.
    OBJECTIVE: The current study aims to explore the longitudinal mediating role of WM capacity between WM updating and mathematical performance, and how the relations change with the age and domains.
    METHODS: A total of 131 Chinese first-graders participated the study.
    METHODS: Participants were required to complete tasks on WM updating and WM capacity in Grade 1 and Grade 2, as well as paper-and-pencil tests on mathematics achievement in Grade 3. The role of WM updating and capacity in the development of pupil\'s mathematical achievement was examined.
    RESULTS: Results revealed that verbal WM updating in Grade 1 predicted basic arithmetic and logical-visuospatial ability in Grade 3 via its cascading effect on verbal WM capacity in Grade 2. Moreover, visuospatial WM updating in Grade 1 predicted visuospatial WM capacity in Grade 2. Visuospatial WM capacity in Grade 1 predicted logical-visuospatial ability in Grade 3 instead of basic arithmetic ability in Grade 3.
    CONCLUSIONS: The findings suggested that WM updating exerts effect on pupil\'s mathematical performance via WM capacity, meanwhile, this effect depends on children\'s mathematics domain.
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