■病毒感染被认为是喉癌的危险因素。鉴于2019年冠状病毒病(COVID-19)对喉组织的可能影响,我们采用双样本孟德尔随机化(MR)方法研究了COVID-19与喉癌之间的因果关系.
■我们利用了来自COVID-19宿主遗传学倡议(2021年1月18日发布)的第五次全基因组关联研究(GWAS)版的遗传数据和大规模喉癌GWAS,包括180例病例和218,612个欧洲血统对照。我们应用了方差逆加权,Egger先生,和加权中位数方法来推断因果关系。我们使用“留一法”进行了敏感性分析,以验证稳健性。
■我们没有发现基因预测的COVID-19与喉癌之间存在因果关系的证据[赔率(OR)=0.24(95%置信区间(CI),0.05-1.26),P=0.09]。然而,我们观察到基因预测的COVID-19住院率之间的显着负相关[OR=0.51(95%CI,0.28-0.95),P=0.03]和重症患者[OR=0.62(95%CI,0.43-0.90),P=0.01]和喉癌。值得注意的是,这项研究发现了重要的遗传变异,如rs13050728,调节干扰素α受体2(IFNAR2)的表达,表明免疫应答途径在COVID-19和癌症中的可能作用。
■这项研究揭示了COVID-19严重程度之间的潜在相互作用,遗传因素,喉癌,强调在这两种情况下研究免疫应答机制的重要性。这些发现有助于理解COVID-19与喉癌之间的复杂相互作用,并可能指导未来对免疫反应作用的研究。特别是涉及IFNAR2。
UNASSIGNED: Viral infections have been implicated as a risk factor for laryngeal cancer. Given the possible effects of Corona virus disease 2019 (COVID-19) on the laryngeal tissue, we investigated the causal link between COVID-19 and laryngeal cancer using a two-sample Mendelian randomization (MR) approach.
UNASSIGNED: We utilized genetic data from the 5th Genome-wide association studies (GWAS) edition of the COVID-19 Host Genetics Initiative (published on January 18, 2021) and a large-scale laryngeal cancer GWAS comprising 180 cases and 218,612 controls of European ancestry. We applied inverse variance weighting, MR Egger, and weighted median methods to infer causality. We performed sensitivity analysis using the \"leave-one-out\" method to verify robustness.
UNASSIGNED: We found no evidence of a causal association between gene-predicted COVID-19 and laryngeal cancer [Odds ratio (OR)=0.24 (95% Confidence intervals (CI), 0.05-1.26), P=0.09]. However, we observed significant inverse associations between gene-predicted COVID-19 hospitalization [OR=0.51 (95% CI, 0.28-0.95), P=0.03] and severe patients [OR=0.62 (95% CI, 0.43-0.90), P=0.01] and laryngeal cancer. Notably, the study detected important genetic variants, such as rs13050728, that modulate the expression of interferon alpha receptor 2 (IFNAR2), indicating possible roles for immune response pathways in both COVID-19 and cancer.
UNASSIGNED: This study reveals a potential interaction between COVID-19 severity, genetic factors, and laryngeal cancer, underscoring the importance of investigating the immune response mechanisms in both conditions. These findings contribute to the understanding of the complex interactions between COVID-19 and laryngeal cancer and may guide future research on the role of immune response, particularly involving IFNAR2.