背景:带状疱疹(HZ)的发病率正在迅速增加,在中国造成临床和经济负担。关于中国居民对每种疫苗接种属性的疫苗偏好和支付意愿(WTP)知之甚少。
目的:本研究旨在了解中国城市成年人(25岁或以上)对HZ疫苗接种计划的偏好,并计算每个疫苗接种属性的WTP。
方法:在本研究中,我们采访了中国9个城市的2864名居民。进行了离散选择实验,以调查居民对HZ疫苗接种的偏好,并预测不同疫苗方案的摄取率。使用混合logit模型来估计每个属性的偏好和WTP。实验中包含了七个不同级别的属性,我们将其他属性的系数除以价格系数来衡量WTP。
结果:疫苗有效性,保护持续时间,副作用的风险,原产地,事实证明,成本会影响中国成年人对HZ疫苗接种的偏好。HZ疫苗的有效性是对居民偏好产生最主要影响的属性,其次是保护期限。居民愿意支付974元人民币(145美元),将疫苗的有效性从45%提高到90%,他们几乎不会支付将疫苗接种时间表从2剂换成1剂。建议将保护率从45%增加到90%,可以最大程度地促进预期的吸收(20.84%)。
结论:中国城市成年人在疫苗有效性之间进行了权衡,保护持续时间,原产地,副作用,和HZ疫苗接种的费用。疫苗的有效性是最重要的特征。居民的WTP最高(974元人民币;145美元),以提高疫苗的有效性。为了最大限度地吸收HZ疫苗,卫生当局应提高疫苗的有效性。
BACKGROUND: The incidence of herpes zoster (HZ) is rapidly increasing, causing both clinical and economic burdens in
China. Very little is known about Chinese residents\' HZ vaccine preferences and willingness to pay (WTP) for each vaccination attribute.
OBJECTIVE: This study aims to elicit the preferences of Chinese urban adults (aged 25 years or older) regarding HZ vaccination programs and to calculate WTP for each vaccination attribute.
METHODS: In this study, we interviewed 2864 residents in 9 cities in
China. A discrete choice experiment was conducted to investigate the residents\' preferences for HZ vaccination and to predict the uptake rate for different vaccine scenarios. A mixed logit model was used to estimate the preferences and WTP for each attribute. Seven attributes with different levels were included in the experiment, and we divided the coefficients of other attributes by the coefficient of price to measure WTP.
RESULTS: Vaccine effectiveness, protection duration, risk of side effects, place of origin, and cost were proven to influence Chinese adults\' preferences for HZ vaccination. The effectiveness of the HZ vaccine was the attribute that had the most predominant impact on residents\' preferences, followed by protection duration. The residents were willing to pay CN ¥974 (US $145) to increase the vaccine effectiveness from 45% to 90%, and they would barely pay to exchange the vaccination schedule from 2 doses to 1 dose. It is suggested that the expected uptake could be promoted the most (by 20.84%) with an increase in the protection rate from 45% to 90%.
CONCLUSIONS: Chinese urban adults made trade-offs between vaccine effectiveness, protection duration, place of origin, side effects, and cost of HZ vaccination. Vaccine effectiveness was the most important characteristic. The residents have the highest WTP (CN ¥974; US $145) for enhancing the effectiveness of vaccines. To maximize HZ vaccine uptake, health authorities should promote vaccine effectiveness.