hand grip strength

手握力
  • 文章类型: Journal Article
    背景:最近的研究强调了肌肉力量作为身体健康的关键因素的重要性,总死亡率风险的有力指标,和预防慢性病的重要目标。这项研究使用了蛋白质组范围的孟德尔随机化分析和低握力的共定位分析来探索肌肉无力的潜在治疗目标。
    方法:我们从四个队列中进行了两个孟德尔随机样本分析,以确定和验证血浆蛋白与低握力之间的因果关系。我们还采用了双向孟德尔随机化分析与Steiger滤波,贝叶斯协同定位,和表型扫描来检测反向因果关系,从而巩固我们的孟德尔随机化研究结果。还对鉴定的蛋白质进行了下游分析,包括淘汰赛模型,富集分析,和蛋白质-蛋白质相互作用网络。最后,我们评估了鉴定的蛋白质的可药用性.
    结果:在Bonferroni意义上(P<6.82×10-5),孟德尔随机化分析显示,三种蛋白质与低握力有因果关系。增加MGP(OR=0.85)和HP(OR=0.96)降低了低握力的风险,而升高的ART4(OR=1.06)增加了低握力的风险。这三种蛋白质在低握力下都没有反向因果关系。贝叶斯共定位表明,MGP共享具有低握力的相同变体(coloc。abf-PPH4=0.826)。进一步的下游分析表明,MGP,在肌肉骨骼系统中高度表达,是肌肉无力的潜在新目标。
    结论:全蛋白质组孟德尔随机化研究发现了三种与肌肉无力风险相关的蛋白质。MGP,HP,ART4作为肌无力的潜在治疗靶点值得进一步研究.
    BACKGROUND: Recent research highlights the importance of muscular strength as a key factor in physical fitness, a strong indicator of overall mortality risk, and a vital target for preventing chronic diseases. This study used a proteome-wide Mendelian randomization analysis plus colocalization analysis for low hand grip strength to explore potential therapeutic targets for muscle weakness.
    METHODS: We conducted two two-sample Mendelian randomization analyses from four cohorts to identify and validate the causal relationship between plasma proteins and low grip strength. We also employed bidirectional Mendelian randomization analysis with Steiger filtering, Bayesian co-localization, and phenotype scanning to detect reverse causality, thereby consolidating our Mendelian randomization findings. Downstream analyses were also undertaken of identified proteins, including knockout models, enrichment analyses, and protein-protein interaction networks. Finally, we assessed the druggability of the identified proteins.
    RESULTS: At Bonferroni significance (P < 6.82 × 10-5), Mendelian randomization analysis revealed that three proteins were causally associated with low grip strength. Increased MGP (OR = 0.85) and HP (OR = 0.96) decreased the risk of low grip strength, whereas elevated ART4 (OR = 1.06) increased the risk of low grip strength. None of the three proteins had reverse causality with low grip strength. Bayesian co-localization suggested that MGP shared the same variant with low grip strength (coloc.abf-PPH4 = 0.826). Further downstream analyses showed that MGP, which is highly expressed in musculoskeletal system, is a potential novel target for muscle weakness.
    CONCLUSIONS: The proteome-wide Mendelian randomization investigation identified three proteins associated with the risk of muscle weakness. MGP, HP, and ART4 deserve further investigation as potential therapeutic targets for muscle weakness.
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  • 文章类型: Journal Article
    先前的观察性研究表明,握力与有害妊娠和围产期结局之间存在关联。然而,这种关系的因果关系仍然不确定。
    本研究旨在调查握力与不良妊娠和围产期结局之间是否存在因果关系,提供证据支持积极干预不良妊娠结局。
    使用双样本孟德尔随机化方法从UKBiobank和FinnGenBiobank中选择GWAS数据作为数据源。采用方差逆加权法作为主要分析方法。通过敏感性分析验证了结果的可靠性,包括Cochran的Q测试,MR-egger截距回归分析,遗漏分析,和漏斗图。独立的队列也用于验证结果的可靠性。
    该研究表明,遗传预测的手握力与后代出生体重之间存在显着正相关,特别是左手握力(β=0.193,95%CI:0.099-0.286,p=0.0001)和右手握力(β=0.310,95%CI:0.235-0.384,p=3.27E-16)。敏感性分析表明无水平多效,留一法分析和漏斗图显示没有异常。验证队列也产生类似的结果。
    这项研究揭示了握力相关性状与后代出生体重之间的显着关联,表明有潜在的保护作用。此外,其他不良妊娠结局也出现阴性预测趋势.通过积极的生活方式和持续监测孕妇的握力来改变握力可能对改善妊娠结局有影响。然而,需要进一步的研究来更全面地调查这些发现.
    UNASSIGNED: Previous observational studies have demonstrated an association between grip strength and detrimental pregnancy and perinatal outcomes. However, the causality of this relationship remains uncertain.
    UNASSIGNED: This study aims to investigate if there is a causal relationship between grip strength and adverse pregnancy and perinatal outcomes, providing evidence to support active intervention for adverse pregnancy outcomes.
    UNASSIGNED: A two-sample Mendelian randomization method was used to select GWAS data from the UK Biobank and the FinnGen Biobank as data sources. The inverse variance weighting method was used as the main analysis method. The reliability of the results was verified through sensitivity analysis, including Cochran\'s Q test, MR-egger intercept regression analysis, leave-one-out analysis, and funnel plot. Independent queues are also used to verify the reliability of the results.
    UNASSIGNED: The study demonstrated a significant positive correlation between genetically predicted hand grip strength and offspring birth weight, specifically left-hand grip strength (β = 0.193, 95 % CI: 0.099-0.286, p = 0.0001) and right-hand grip strength (β = 0.310, 95 % CI: 0.235-0.384, p = 3.27E-16). Sensitivity analysis indicated no horizontal multi-effect, and leave-one-out analysis along with the funnel plot showed no abnormalities. The verification queue also yielded similar results.
    UNASSIGNED: This study revealed a significant association between grip strength-related traits and offspring birth weight, suggesting a potential protective effect. Moreover, a negative predictive trend was observed for other adverse pregnancy outcomes. Modifying grip strength through an active lifestyle and continuous monitoring of pregnant women\'s grip strength may have implications for improving pregnancy outcomes. However, further research is warranted to investigate these findings more comprehensively.
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  • 文章类型: Journal Article
    背景:新的证据表明,BCAA代谢的改变可能与肌肉减少症的发病机制有关。然而,支链氨基酸(BCAAs)与肌肉减少症之间的关系尚未完全了解,和现有的文献提出了相互矛盾的结果。在这项研究中,我们进行了一项基于社区的研究,涉及超过100,000名英国成年人,以全面探索BCAA与肌少症之间的关联,并评估肌肉质量在介导BCAA与肌肉力量之间关系中的潜在作用。
    方法:多变量线性回归分析了循环BCAA与肌肉质量/力量之间的关系。Logistic回归分析评估循环BCAAs和四分位数BCAAs对肌肉减少症风险的影响。亚组分析探讨了不同年龄的关联变化,和性别。中介分析研究了肌肉质量对BCAA-肌肉力量关系的潜在中介作用。
    结果:在108,017名参与者中(平均年龄:56.40±8.09岁;46.23%的男性),观察到总BCAA,异亮氨酸,亮氨酸,缬氨酸,和肌肉质量(β,0.56-2.53;p<0.05)和总BCAA,亮氨酸,缬氨酸,和肌肉力量(β,0.91-3.44;p<0.05)。Logistic回归分析显示,循环缬氨酸的增加与肌肉减少症风险降低47%相关(比值比=0.53;95%置信区间=0.3-0.94;p=0.029)。亚组分析表明,男性和年龄≥60岁的个体的循环BCAA与肌肉质量/力量之间存在很强的关联。中介分析表明,肌肉质量完全介导了总BCAA,缬氨酸水平和肌肉力量,部分介导了亮氨酸水平和肌肉力量之间的关系,掩盖异亮氨酸对肌肉力量的真正影响。
    结论:这项研究表明BCAA在保持肌肉质量/力量方面的潜在益处,突出的肌肉质量可能是BCAA-肌肉力量关联的媒介。我们的发现为临床预防和治疗肌肉减少症和涉及肌肉质量/力量丧失的相关疾病提供了新的证据。
    BACKGROUND: Emerging evidence suggests that alterations in BCAA metabolism may contribute to the pathogenesis of sarcopenia. However, the relationship between branched-chain amino acids (BCAAs) and sarcopenia is incompletely understood, and existing literature presents conflicting results. In this study, we conducted a community-based study involving > 100,000 United Kingdom adults to comprehensively explore the association between BCAAs and sarcopenia, and assess the potential role of muscle mass in mediating the relationship between BCAAs and muscle strength.
    METHODS: Multivariable linear regression analysis examined the relationship between circulating BCAAs and muscle mass/strength. Logistic regression analysis assessed the impact of circulating BCAAs and quartiles of BCAAs on sarcopenia risk. Subgroup analyses explored the variations in associations across age, and gender. Mediation analysis investigated the potential mediating effect of muscle mass on the BCAA-muscle strength relationship.
    RESULTS: Among 108,017 participants (mean age: 56.40 ± 8.09 years; 46.23% men), positive associations were observed between total BCAA, isoleucine, leucine, valine, and muscle mass (beta, 0.56-2.53; p < 0.05) and between total BCAA, leucine, valine, and muscle strength (beta, 0.91-3.44; p < 0.05). Logistic regression analysis revealed that increased circulating valine was associated with a 47% reduced sarcopenia risk (odds ratio = 0.53; 95% confidence interval = 0.3-0.94; p = 0.029). Subgroup analyses demonstrated strong associations between circulating BCAAs and muscle mass/strength in men and individuals aged ≥ 60 years. Mediation analysis suggested that muscle mass completely mediated the relationship between total BCAA, and valine levels and muscle strength, partially mediated the relationship between leucine levels and muscle strength, obscuring the true effect of isoleucine on muscle strength.
    CONCLUSIONS: This study suggested the potential benefits of BCAAs in preserving muscle mass/strength and highlighted muscle mass might be mediator of BCAA-muscle strength association. Our findings contribute new evidence for the clinical prevention and treatment of sarcopenia and related conditions involving muscle mass/strength loss.
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  • 文章类型: Journal Article
    背景:肌肉减少症是肌肉质量和功能的进行性丧失。由于骨骼肌在代谢稳态中起关键作用,确定血液代谢产物与肌肉减少症成分的关系将有助于了解肌肉减少症的病因。
    方法:进行了两个样本的孟德尔随机研究,以检查血液代谢物与肌肉减少症成分的因果关系。309种已知代谢物的汇总遗传关联数据来自英国双胞胎队列和KORAF4研究(7824名参与者)。肌肉减少症成分的统计摘要[手握力(HGS),步行速度(WP),和阑尾瘦体重(ALM)]从IEUOpenGWAS项目(461,089名参与者)获得。采用逆方差加权法,和MR-Egger,加权中位数,和MR-PRESSO用于敏感性分析。进一步进行代谢途径分析。
    结果:从275种已知的代谢产物库中选择了54种与肌肉减少症成分相关的代谢产物。与肌肉减少症成分有因果关系的代谢物主要富含氨基糖和核苷酸糖代谢,半乳糖代谢,果糖和甘露糖代谢,肉碱合成,和生物素代谢。十五烷酸(15:0)与ALM的关联,Bonferroni校正后,3-脱氢肉碱和异戊酰基肉碱与HGS的阈值为P<1.82×10-4(0.05/275)。同时,猪去氧胆酸盐和甘氨酸与正确的HGS的关联,和硫酸雄酮与ALM在敏感性分析中具有显著意义。
    结论:来自不同代谢途径的血液代谢产物与肌少症的成分有因果关系。这些发现可能有助于了解肌肉减少症的生物学机制和肌肉健康的靶向药物开发。
    BACKGROUND: Sarcopenia is a progressive loss of muscle mass and function. Since skeletal muscle plays a critical role in metabolic homeostasis, identifying the relationship of blood metabolites with sarcopenia components would help understand the etiology of sarcopenia.
    METHODS: A two-sample Mendelian randomization study was conducted to examine the causal relationship of blood metabolites with the components of sarcopenia. Summary genetic association data for 309 known metabolites were obtained from the Twins UK cohort and KORA F4 study (7824 participants). The summary statistics for sarcopenia components [hand grip strength (HGS), walking pace (WP), and appendicular lean mass (ALM)] were obtained from the IEU Open GWAS project (461,089 participants). The inverse variance weighted method was used, and the MR-Egger, weighted median, and MR-PRESSO were used for the sensitivity analyses. Metabolic pathways analysis was further performed.
    RESULTS: Fifty-four metabolites associated with sarcopenia components were selected from 275 known metabolites pool. Metabolites that are causally linked to the sarcopenia components were mainly enriched in amino sugar and nucleotide sugar metabolism, galactose metabolism, fructose and mannose metabolism, carnitine synthesis, and biotin metabolism. The associations of pentadecanoate (15:0) with ALM, and 3-dehydrocarnitine and isovalerylcarnitine with HGS were significant after Bonferroni correction with a threshold of P < 1.82 × 10- 4 (0.05/275). Meanwhile, the association of hyodeoxycholate and glycine with the right HGS, and androsterone sulfate with ALM were significant in the sensitivity analyses.
    CONCLUSIONS: Blood metabolites from different metabolism pathways were causally related to the components of sarcopenia. These findings might benefit the understanding of the biological mechanisms of sarcopenia and targeted drugs development for muscle health.
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  • 文章类型: Journal Article
    先前的研究表明,马赛人和欧洲人倾向于对马赛人男性面孔的体力和侵略性进行评级。校准到手的握力(HGS)。然而,不同人群对这些面孔吸引力的看法不同。在这项研究中,通过几何形态计量学创造了三个年轻的马赛人变形,并描绘平均样本和两个极值(HGS的±4SD),来自坦桑尼亚的男性和女性进行了评估,捷克共和国,俄罗斯,巴基斯坦,中国,和墨西哥(总样本=1540)。这项研究的目的是测试跨文化差异的感知年轻马赛人的复合材料校准HGS,关注四个特征:体力,吸引力,侵略性,和乐于助人。来自所有六种文化的个体能够区分低,中等,和高HGS肖像。在所有研究人群中,HGS较低的马赛人的肖像被认为不那么有吸引力,更具侵略性,和更少的帮助。这表明来自不同人群的人对基于面部形状的体力有着相似的看法,以及将类似的社交品质,如侵略性和乐于助人归因于这些面部图像。来自所有样本的参与者都将弱小的马赛人的合成图像评为最不吸引人。
    Previous research has demonstrated that Maasai and Europeans tend to align in their ratings of the physical strength and aggressiveness of Maasai male faces, calibrated to hand grip strength (HGS). However, perceptions of attractiveness of these faces differed among populations. In this study, three morphs of young Maasai men created by means of geometric morphometrics, and depicting the average sample and two extrema (± 4 SD of HGS), were assessed by men and women from Tanzania, Czech Republic, Russia, Pakistan, China, and Mexico (total sample = 1540). The aim of this study was to test cross-cultural differences in the perception of young Maasai men\'s composites calibrated to HGS, focusing on four traits: physical strength, attractiveness, aggressiveness, and helpfulness. Individuals from all six cultures were able to distinguish between low, medium, and high HGS portraits. Across all study populations, portrait of Maasai men with lower HGS was perceived as less attractive, more aggressive, and less helpful. This suggests that people from diverse populations share similar perceptions of physical strength based on facial shape, as well as attribute similar social qualities like aggressiveness and helpfulness to these facial images. Participants from all samples rated the composite image of weak Maasai men as the least attractive.
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  • 文章类型: Journal Article
    胆石症是一种常见的消化系统疾病,可引发无数不良并发症。肌少症与各种消化系统疾病的相关性已被广泛研究,而其与胆石症的关联仍未报道。我们旨在通过前瞻性和孟德尔随机化(MR)分析来调查相关性,并建立反映少肌症相关标志物对胆石症影响的定量评分。这项前瞻性研究涉及来自英国生物银行的448627名参与者。Cox比例风险模型用于研究少肌症相关标志物与胆石症之间的相关性。为了定量评估胆石症的风险,SARCHO评分来自多变量Cox模型.进行双向双样本MR分析以验证因果关联。在12年的中位随访期间,共有16738名个体发生胆石症。胆石症的危险比(HR)在骨骼肌指数三位数上逐步降低(最高三位数:参考;中间三位数:1.23,p<.001;最低三位数:1.33,p<.001)。握力的三分位数显示出类似的模式。与步行速度正常的人相比,步行速度缓慢的人患胆石症的风险更高(HR1.23;p<.001)。我们的SARCHO评分更好地量化了胆石症的风险。MR分析显示肌肉质量与胆石症之间存在因果关系(OR0.81;p<.001)。未观察到胆石症对瘦体重的因果影响。前瞻性和MR分析一致表明,肌肉质量降低的个体患胆石症的风险增加。此外,SARCHO评分进一步量化胆石症发生风险。这些发现为肌肉加强预防胆石症提供了令人信服的证据。
    Cholelithiasis is a common digestive disease that drives a myriad of adverse complications. The correlation between sarcopenia and various digestive disorders has been extensively researched, whereas its association with cholelithiasis remains unreported. We aimed to investigate the association through prospective and Mendelian randomization (MR) analyses and establish a quantitative score reflecting the impact of sarcopenia-related markers on cholelithiasis. The prospective study involved 448 627 participants from the UK Biobank. Cox proportional hazard models were employed to investigate the correlation between sarcopenia-related markers and cholelithiasis. To quantitatively assess cholelithiasis risk, the SARCHO score was derived from a multivariable Cox model. Bidirectional two-sample MR analysis was conducted to validate the causal association. A total of 16 738 individuals developed cholelithiasis during a median follow-up of 12 years. Hazard ratios (HRs) of cholelithiasis decreased stepwise over skeletal muscle index tertiles (highest tertile: reference; middle tertile: 1.23, p < .001; lowest tertile: 1.33, p < .001). The tertiles of grip strength showed a similar pattern. Individuals with slow walking pace had a higher risk of cholelithiasis compared to those with normal walking pace (HR 1.23; p < .001). Our SARCHO score better quantifies the risk of cholelithiasis. MR analysis showed a causal relationship between muscle mass and cholelithiasis (OR 0.81; p < .001). No causal effect of cholelithiasis on lean mass was observed. Prospective and MR analyses have consistently demonstrated an increased risk of cholelithiasis in individuals with decreased muscle mass. Additionally, SARCHO score further quantified the cholelithiasis occurrence risk. These findings provide compelling evidence for muscle strengthening in preventing cholelithiasis.
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  • 文章类型: Journal Article
    先前的观察性研究表明,炎症性肠病(IBD)与肌肉减少症之间存在关联。然而,IBD(包括溃疡性结肠炎和克罗恩病)与肌肉减少症之间的因果关系尚不清楚.因此,本研究使用孟德尔随机化(MR)分析,调查了基因预测的IBD在少肌症的发生中是否发挥了作用.这项研究使用与IBD显着相关的独立单核苷酸多态性(SNP)作为仪器变量(IVs)。肌肉减少症相关成分(手握力,步行空间,和阑尾瘦体重(ALM)作为结果因素进行了调查,从英国生物银行获得的关于肌肉减少症这些成分的汇总数据。IVW-MR分析显示,IBD与手握力(左右)以及ALM之间存在显着负相关。此外,IVW-MR分析的结果提供了基因预测的克罗恩病与手握力和ALM之间因果关系的有力证据。然而,溃疡性结肠炎与肌肉减少症相关性状之间未发现显著关联.灵敏度测试证实了上述MR分析的准确性和鲁棒性。结论:我们的MR分析显示克罗恩病对手部握力和ALM的因果关系。这表明克罗恩病可能是肌肉减少症的潜在危险因素。
    Previous observational studies have shown an association between inflammatory bowel disease (IBD) and sarcopenia. However, the causal relationship between IBD (including ulcerative colitis and Crohn\'s disease) and sarcopenia remains unclear. Thus, this study investigated whether genetically predicted IBD play a function in the occurrence of sarcopenia using Mendelian randomization (MR) analysis. This study used independent single nucleotide polymorphisms (SNPs) significantly associated with IBD as instrument variables (IVs). Sarcopenia-related components (hand grip strength, walking space, and appendicular lean mass (ALM)) were investigated as outcome factors, with summary-level data regarding these components of sarcopenia obtained from the UK Biobank. The IVW-MR analysis revealed that there were significant negative associations between IBD and hand grip strength (both left and right) as well as ALM. Besides, the results of IVW-MR analysis provided strong evidence of a causal relationship between genetically predicted Crohn\'s disease and hand grip strength and ALM. However, there were no significant associations found between ulcerative colitis and sarcopenia-related traits. Sensitivity tests confirmed the accuracy and robustness of the above MR analysis. Conclusions: Our MR analysis showed the causal effect of Crohn\'s disease on hand grip strength and ALM. This suggests that Crohn\'s disease may be a potential risk factor for sarcopenia.
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  • 文章类型: Journal Article
    背景:据报道,硒(Se)对动物中的重金属具有拮抗作用。然而,缺乏流行病学研究,研究硒是否可以减轻镉(Cd)和铅(Pb)对中老年人手握力(HGS)的不利影响。方法:本研究使用2011-2014年全国健康与营养调查(NHANES)的数据。HGS测量由训练有素的检查者用测力计进行。硒的浓度,Cd,通过电感耦合等离子体质谱法测定血液中的铅。我们采用线性回归,受限三次样条,和分位数g计算(qgcomp)来评估重金属和HGS之间的个体和组合关联。该研究还探讨了硒对这些关联的潜在影响。结果:在调整了混杂因素的单个金属和多金属模型中,一般线性回归显示硒与HGS呈正相关,而Cd和Pb与它成反比。在不同的Se-Cd和Se-Pb浓度下,高硒相对于低硒可以减弱镉和铅的HGS影响。Se与最大值和组合HGS之间存在倒U形相关性,硒的效益稳定在200μg/L以上Se四分位数的分层分析显示,Cd和Pb的不利HGS效应随着Se水平的增加而减弱。Qgcomp回归分析检测到硒减轻了Cd和Pb联合暴露对HGS的损害。随后的亚组分析确定了女性的敏感性,老年人,和那些有糖尿病风险的人,由重金属引起的HGS损害,适度补充硒有利于减轻这种影响。在有糖尿病风险的人群中,硒对重金属毒性诱导的HGS还原的保护作用被抑制,提示糖尿病患者应特别避免重金属引起的手握损伤。结论:血液中Cd和Pb水平与HGS呈负相关。硒可以减轻这种负面影响,但其有效性高于200μg/L。女人,老年人,那些有糖尿病风险的人更容易受到重金属的HGS损害。虽然补充硒可以有所帮助,其对糖尿病高危人群的保护作用有限。
    Background: Selenium (Se) has been reported to have an antagonistic effect on heavy metals in animals. Nevertheless, there is a lack of epidemiological research examining whether Se can mitigate the adverse effects of cadmium (Cd) and lead (Pb) on hand grip strength (HGS) in middle-aged and elderly individuals. Methods: This study used data from the 2011-2014 National Health and Nutrition Examination Survey (NHANES). HGS measurements were conducted by trained examiners with a dynamometer. Concentrations of Se, Cd, and Pb in blood were determined via inductively coupled plasma mass spectrometry. We employed linear regression, restricted cubic splines, and quantile g-computation (qgcomp) to assess individual and combined associations between heavy metals and HGS. The study also explored the potential influence of Se on these associations. Results: In both individual metal and multi-metal models adjusted for confounders, general linear regression showed Se\'s positive association with HGS, while Cd and Pb inversely related to it. At varying Se-Cd and Se-Pb concentrations, high Se relative to low Se can attenuate Cd and Pb\'s HGS impact. An inverted U-shaped correlation exists between Se and both maximum and combined HGS, with Se\'s benefit plateauing beyond approximately 200 μg/L. Stratified analysis by Se quartiles reveals Cd and Pb\'s adverse HGS effects diminishing as Se levels increase. Qgcomp regression analysis detected Se alleviating HGS damage from combined Cd and Pb exposure. Subsequent subgroup analyses identified the sensitivity of women, the elderly, and those at risk of diabetes to HGS impairment caused by heavy metals, with moderate Se supplementation beneficial in mitigating this effect. In the population at risk for diabetes, the protective role of Se against heavy metal toxicity-induced HGS reduction is inhibited, suggesting that diabetic individuals should particularly avoid heavy metal-induced handgrip impairment. Conclusion: Blood Cd and Pb levels are negatively correlated with HGS. Se can mitigate this negative impact, but its effectiveness plateaus beyond 200 μg/L. Women, the elderly, and those at risk of diabetes are more vulnerable to HGS damage from heavy metals. While Se supplementation can help, its protective effect is limited in high diabetes risk groups.
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  • 文章类型: Journal Article
    背景:观察性研究表明抑郁症与肌肉减少症有关。然而,抑郁症与肌少症之间的因果关系尚不清楚.
    目的:探讨抑郁症与肌肉减少症的因果关系。
    方法:我们进行了孟德尔随机化(MR)分析,以确定抑郁症与肌肉减少症相关性状之间的双向关系。摘要水平数据和独立变异用作工具变量来自抑郁症的大型全基因组关联研究(414055例和892299例对照),阑尾瘦体重(ALM,450243名参与者),和握力(暴露:360000名参与者;结果:334925名参与者)。
    结果:我们发现抑郁与ALM降低呈负相关[比值比(OR):0.932,95%置信区间(95CI):0.889-0.979,P=0.005]。在反向MR分析中,我们还观察到握力与抑郁呈负相关(OR:0.200,95CI:0.108-0.370,P<0.001).在敏感性分析中获得了类似的结果。
    结论:抑郁症与肌肉质量下降有因果关系,肌肉力量下降可能导致更高的抑郁症风险。
    BACKGROUND: Observational studies have suggested that depression is associated with sarcopenia. However, the causal relationship between depression and sarcopenia remains unclear.
    OBJECTIVE: To investigate the causal relationship between depression and sarcopenia.
    METHODS: We performed a Mendelian randomization (MR) analysis to identify the bidirectional relationship between depression and sarcopenia-related traits. Summary-level data and independent variants used as instrumental variables came from large genome-wide association studies of depression (414055 cases and 892299 controls), of appendicular lean mass (ALM, 450243 participants), and of hand grip strength (exposure: 360000 participants; outcome: 334925 participants).
    RESULTS: We identified a negative association of depression with lower ALM [odds ratio (OR): 0.932, 95% confidence interval (95%CI): 0.889-0.979, P = 0.005]. In the reverse MR analysis, we also observed an inverse association of hand grip strength with depression (OR: 0.200, 95%CI: 0.108-0.370, P < 0.001). Similar results were obtained in sensitivity analyses.
    CONCLUSIONS: Depression was causally related to decreased muscle mass, and declined muscle strength might lead to a higher risk of depression.
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  • 文章类型: Journal Article
    背景:一些观察性研究报道了手握力(HGS)与肺功能(PF)之间的关联。然而,因果关系尚不清楚。为了调查HGS和PF是否存在因果关系,我们进行了孟德尔随机化(MR)分析.
    方法:我们从MRC-IEU联盟中鉴定出110个独立的单核苷酸多态性(SNP)用于右手握力(RHGS),103个独立的单核苷酸多态性用于左手握力(LHGS)。使用逆方差加权(IVW)方法计算MR估计值,并进一步进行多重敏感性分析。
    结果:HGS的遗传责任与用力肺活量(FVC)和一秒钟用力呼气量(FEV1)呈正相关,但不是FEV1/FVC。此外,RHGS和FVC之间存在正相关(OR=1.519;95%CI,1.418-1.627;P=8.96E-33),和FEV1(OR=1.486;95%CI,1.390-1.589;P=3.19E-31);LHGS与FVC(OR=1.464;95%CI,1.385-1.548;P=2.83E-41)和FEV1(OR=1.419;95%CI,1.340-1.502;P=3.19E-33)之间存在正因果关系。然而,RHGS与FEV1/FVC之间无相关性(OR=0.998;95%CI,0.902-1.103;P=9.62E-01),LHGS与FEV1/FVC之间无相关性(OR=0.966;95%CI,0.861-1.083;P=5.52E-01).在几个敏感性分析中显示了类似的结果。
    结论:我们的研究在遗传水平上支持HGS与FVC和FEV1正相关,但与FEV1/FVC无关。作为PF评估的潜在指标,对PF损害中HGS的干预措施值得进一步探索。
    BACKGROUND: Several observational studies have reported an association between hand grip strength (HGS) and pulmonary function (PF). However, causality is unclear. To investigate whether HGS and PF are causally associated, we performed Mendelian randomization (MR) analyses.
    METHODS: We identified 110 independent single nucleotide polymorphisms (SNPs) for right-hand grip strength (RHGS) and 103 independent SNPs for left-hand grip strength (LHGS) at the genome-wide significant threshold (P < 5 × 10-8) from MRC-IEU Consortium and evaluated these related to PF. MR estimates were calculated using the inverse-variance weighted (IVW) method and multiple sensitivity analyses were further performed.
    RESULTS: Genetical liability to HGS was positively causally associated with forced vital capacity (FVC) and forced expiratory volume in one second (FEV1), but not with FEV1/FVC. In addition, there was positive causal association between RHGS and FVC (OR=1.519; 95% CI, 1.418-1.627; P=8.96E-33), and FEV1 (OR=1.486; 95% CI, 1.390-1.589; P=3.19E-31); and positive causal association between LHGS and FVC (OR=1.464; 95% CI, 1.385-1.548; P=2.83E-41) and FEV1 (OR=1.419; 95% CI, 1.340-1.502; P=3.19E-33). Nevertheless, no associations were observed between RHGS and FEV1/FVC (OR=0.998; 95% CI, 0.902-1.103; P=9.62E-01) and between LHGS and FEV1/FVC (OR=0.966; 95% CI, 0.861-1.083; P=5.52E-01). Similar results were shown in several sensitivity analyses.
    CONCLUSIONS: Our study provides support at the genetic level that HGS is positively causally associated with FVC and FEV1, but not with FEV1/FVC. Interventions for HGS in PF impairment deserve further exploration as potential indicators of PF assessment.
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