目的:胰腺癌病例正在增加,据报道,这种疾病的风险随着年龄的增长而增加。近年来,关于胰腺癌患者身体功能的报道越来越多.应建立6分钟步行距离(6MWD)等方法来评估身体机能,运动能力的下降是这些患者的重要指标。最近,6MWD也已用于评估胰腺癌患者的身体功能。在健康的老年人中,据报道,6MWD的下降与内在能力和健康状况有关。这些因素使得评估6MWD变得重要。然而,6MWD的测量需要相当大的测量环境。五次坐立(FTSTS)测试是一种简单的方法,可以使用椅子进行。FTSTS被认为是胰腺癌患者的有用评估量表,因为如果可以通过评估FTSTS来估计6MWD的下降,则在临床实践中很容易估计身体功能的下降。该研究的目的是阐明这一假设,并确定在临床实践中确定6MWD下降所需的截止值。
方法:研究了60例术前胰腺癌患者的身体功能评估。6MWD(<400米)是客观变量,并进行二元logistic回归分析,随着年龄,BMI,性别,FTSTS,和HGS作为解释变量。对解释变量进行受试者工作特征(ROC)曲线分析,根据逻辑回归分析,发现这些数据是显著的。还计算曲线下面积(AUC)。灵敏度,特异性,负预测值(NPV),和阳性预测值(PPV)进行评估。本研究获得广岛大学医院伦理委员会批准(批准号:E808-1)。
结果:60例患者中有57例纳入分析。Logistic回归分析显示FTSTS是显著的解释变量;ROC曲线分析显示AUC为0.872,截止值为8.98s。特异性,PPV,净现值为82.4%,80.0%,63.6%,91.4%,分别。
结论:通过FTSTS可以发现胰腺癌患者术前6MWD的降低。
OBJECTIVE: Cases of pancreatic cancer are increasing, and the risk of developing this disease reportedly increases with age. In recent years, there has been an increasing number of
reports on physical function in patients with pancreatic cancer. Methods such as the 6-min walk distance (6 MWD) should be established to evaluate physical function, as a decline in exercise capacity is an important index in these patients. Recently, the 6 MWD has also been used to evaluate physical function in patients with pancreatic cancer. In healthy older adults, a decrease in 6 MWD is reportedly associated with intrinsic capacity and health status. Such factors make assessing 6 MWD important. However, the measurement of 6 MWD requires a sizable measurement environment. The five times sit to stand (FTSTS) test is a simple method that can be performed using a chair. FTSTS is hypothesized to be a useful assessment scale in patients with pancreatic cancer because it is easy to estimate the decline in physical function in clinical practice if the decline in 6 MWD can be estimated by evaluating FTSTS. The study\'s purpose was to clarify this hypothesis and ascertain the cutoff required to determine the decrease in 6 MWD in clinical practice.
METHODS: Sixty consecutive patients with preoperative pancreatic cancer who were assessed for physical function were studied. 6 MWD (< 400 m) was the objective variable, and binary logistic regression analysis was performed, with age, BMI, sex, FTSTS, and HGS as explanatory variables. Receiver-operating characteristic (ROC) curve analysis was performed for the explanatory variables, which were found to be significant based on logistic regression analysis. The area under the curve (AUC) was also calculated. Sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) were evaluated. This study was approved by Hiroshima University Hospital\'s ethics committee (approval number: E808-1).
RESULTS: Fifty-seven of the 60 patients were included in the analysis. Logistic regression analysis showed that FTSTS was a significant explanatory variable; ROC curve analysis showed an AUC of 0.872 and a cutoff value of 8.98 s. The sensitivity, specificity, PPV, and NPV were 82.4%, 80.0%, 63.6%, and 91.4%, respectively.
CONCLUSIONS: A decrease in 6 MWD in preoperative pancreatic cancer patients can be identified by performing FTSTS.