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Abstract：
Previous observational studies have shown an association between inflammatory bowel disease (IBD) and sarcopenia. However, the causal relationship between IBD (including ulcerative colitis and Crohn\'s disease) and sarcopenia remains unclear. Thus, this study investigated whether genetically predicted IBD play a function in the occurrence of sarcopenia using Mendelian randomization (MR) analysis. This study used independent single nucleotide polymorphisms (SNPs) significantly associated with IBD as instrument variables (IVs). Sarcopenia-related components (hand grip strength, walking space, and appendicular lean mass (ALM)) were investigated as outcome factors, with summary-level data regarding these components of sarcopenia obtained from the UK Biobank. The IVW-MR analysis revealed that there were significant negative associations between IBD and hand grip strength (both left and right) as well as ALM. Besides, the results of IVW-MR analysis provided strong evidence of a causal relationship between genetically predicted Crohn\'s disease and hand grip strength and ALM. However, there were no significant associations found between ulcerative colitis and sarcopenia-related traits. Sensitivity tests confirmed the accuracy and robustness of the above MR analysis. Conclusions: Our MR analysis showed the causal effect of Crohn\'s disease on hand grip strength and ALM. This suggests that Crohn\'s disease may be a potential risk factor for sarcopenia.
摘要：
先前的观察性研究表明，炎症性肠病（IBD）与肌肉减少症之间存在关联。然而,IBD(包括溃疡性结肠炎和克罗恩病)与肌肉减少症之间的因果关系尚不清楚.因此，本研究使用孟德尔随机化(MR)分析,调查了基因预测的IBD在少肌症的发生中是否发挥了作用.这项研究使用与IBD显着相关的独立单核苷酸多态性（SNP）作为仪器变量（IVs）。肌肉减少症相关成分（手握力，步行空间,和阑尾瘦体重(ALM)作为结果因素进行了调查，从英国生物银行获得的关于肌肉减少症这些成分的汇总数据。IVW-MR分析显示，IBD与手握力（左右）以及ALM之间存在显着负相关。此外,IVW-MR分析的结果提供了基因预测的克罗恩病与手握力和ALM之间因果关系的有力证据。然而,溃疡性结肠炎与肌肉减少症相关性状之间未发现显著关联.灵敏度测试证实了上述MR分析的准确性和鲁棒性。结论：我们的MR分析显示克罗恩病对手部握力和ALM的因果关系。这表明克罗恩病可能是肌肉减少症的潜在危险因素。
