PDF(Pubmed)
Abstract：
BACKGROUND: Observational studies have suggested that depression is associated with sarcopenia. However, the causal relationship between depression and sarcopenia remains unclear.
OBJECTIVE: To investigate the causal relationship between depression and sarcopenia.
METHODS: We performed a Mendelian randomization (MR) analysis to identify the bidirectional relationship between depression and sarcopenia-related traits. Summary-level data and independent variants used as instrumental variables came from large genome-wide association studies of depression (414055 cases and 892299 controls), of appendicular lean mass (ALM, 450243 participants), and of hand grip strength (exposure: 360000 participants; outcome: 334925 participants).
RESULTS: We identified a negative association of depression with lower ALM [odds ratio (OR): 0.932, 95% confidence interval (95%CI): 0.889-0.979, P = 0.005]. In the reverse MR analysis, we also observed an inverse association of hand grip strength with depression (OR: 0.200, 95%CI: 0.108-0.370, P < 0.001). Similar results were obtained in sensitivity analyses.
CONCLUSIONS: Depression was causally related to decreased muscle mass, and declined muscle strength might lead to a higher risk of depression.
OBJECTIVE: To investigate the causal relationship between depression and sarcopenia.
METHODS: We performed a Mendelian randomization (MR) analysis to identify the bidirectional relationship between depression and sarcopenia-related traits. Summary-level data and independent variants used as instrumental variables came from large genome-wide association studies of depression (414055 cases and 892299 controls), of appendicular lean mass (ALM, 450243 participants), and of hand grip strength (exposure: 360000 participants; outcome: 334925 participants).
RESULTS: We identified a negative association of depression with lower ALM [odds ratio (OR): 0.932, 95% confidence interval (95%CI): 0.889-0.979, P = 0.005]. In the reverse MR analysis, we also observed an inverse association of hand grip strength with depression (OR: 0.200, 95%CI: 0.108-0.370, P < 0.001). Similar results were obtained in sensitivity analyses.
CONCLUSIONS: Depression was causally related to decreased muscle mass, and declined muscle strength might lead to a higher risk of depression.
摘要：
背景：观察性研究表明抑郁症与肌肉减少症有关。然而,抑郁症与肌少症之间的因果关系尚不清楚.
目的：探讨抑郁症与肌肉减少症的因果关系。
方法：我们进行了孟德尔随机化（MR）分析，以确定抑郁症与肌肉减少症相关性状之间的双向关系。摘要水平数据和独立变异用作工具变量来自抑郁症的大型全基因组关联研究（414055例和892299例对照），阑尾瘦体重(ALM，450243名参与者)，和握力（暴露：360000名参与者；结果：334925名参与者）。
结果：我们发现抑郁与ALM降低呈负相关[比值比（OR）：0.932，95%置信区间（95CI）：0.889-0.979，P=0.005]。在反向MR分析中，我们还观察到握力与抑郁呈负相关(OR:0.200,95CI:0.108-0.370,P<0.001).在敏感性分析中获得了类似的结果。
结论：抑郁症与肌肉质量下降有因果关系，肌肉力量下降可能导致更高的抑郁症风险。
目的：探讨抑郁症与肌肉减少症的因果关系。
方法：我们进行了孟德尔随机化（MR）分析，以确定抑郁症与肌肉减少症相关性状之间的双向关系。摘要水平数据和独立变异用作工具变量来自抑郁症的大型全基因组关联研究（414055例和892299例对照），阑尾瘦体重(ALM，450243名参与者)，和握力（暴露：360000名参与者；结果：334925名参与者）。
结果：我们发现抑郁与ALM降低呈负相关[比值比（OR）：0.932，95%置信区间（95CI）：0.889-0.979，P=0.005]。在反向MR分析中，我们还观察到握力与抑郁呈负相关(OR:0.200,95CI:0.108-0.370,P<0.001).在敏感性分析中获得了类似的结果。
结论：抑郁症与肌肉质量下降有因果关系，肌肉力量下降可能导致更高的抑郁症风险。
