■抑郁症是主要的全球公共卫生问题之一,在过去的十年中,年轻人的抑郁水平急剧上升。抑郁症的神经可塑性理论假设神经可塑性出现故障,负责学习,记忆,和适应性行为,是该疾病临床表现的主要来源。然而,抑郁症状对联想学习的影响仍未得到充分研究。
■我们使用差异恐惧条件范式来研究抑郁症状对恐惧获得和灭绝学习的影响。皮肤电导反应(SCR)是一个客观的评价指标,和紧张的评级,讨人喜欢,非条件刺激(US)预期是主观评价指标。此外,我们使用计算强化学习模型生成的关联性来表征皮肤电导响应。
■研究结果表明,根据皮肤电导反应的结果,与没有抑郁症状的人相比,有抑郁症状的人在恐惧习得学习方面表现出明显的障碍。此外,在歧视恐惧学习任务中,皮肤电导反应与关联性呈正相关,根据混合模型在无抑郁症状组中的估计。此外,在没有抑郁症状的组中,喜爱度评分改善了灭绝后的学习,在有抑郁症状的组中没有观察到这种增加。
该研究强调,患有明显抑郁症状的个体表现出恐惧的获得和灭绝学习能力受损,暗示联想学习可能存在缺陷。采用混合模型来分析学习过程可以更深入地了解人类的联想学习过程,从而提高对这些心理健康问题的理解和治疗。
UNASSIGNED: Depression is one of the primary global public health issues, and there has been a dramatic increase in depression levels among young people over the past decade. The neuroplasticity theory of depression postulates that a malfunction in neural plasticity, which is responsible for learning, memory, and adaptive behavior, is the primary source of the disorder\'s clinical manifestations. Nevertheless, the impact of depression symptoms on associative learning remains underexplored.
UNASSIGNED: We used the differential fear conditioning paradigm to investigate the effects of depressive symptoms on fear acquisition and extinction learning. Skin conductance response (SCR) is an objective evaluation indicator, and ratings of nervousness, likeability, and unconditioned stimuli (US) expectancy are subjective evaluation indicators. In addition, we used associability generated by a computational reinforcement learning model to characterize the skin conductance response.
UNASSIGNED: The findings indicate that individuals with depressive symptoms exhibited significant impairment in fear acquisition learning compared to those without depressive symptoms based on the results of the skin conductance response. Moreover, in the discrimination fear learning task, the skin conductance response was positively correlated with associability, as estimated by the hybrid model in the group without depressive symptoms. Additionally, the likeability rating scores improved post-extinction learning in the group without depressive symptoms, and no such increase was observed in the group with depressive symptoms.
UNASSIGNED: The study highlights that individuals with pronounced depressive symptoms exhibit impaired fear acquisition and extinction learning, suggesting a possible deficit in associative learning. Employing the hybrid model to analyze the learning process offers a deeper insight into the associative learning processes of humans, thus allowing for improved comprehension and treatment of these mental health problems.