特定因素对恐惧消退或暴露疗法的影响揭示了有希望的结果，例如，性或压力荷尔蒙如何发挥能力来批判性地改变灭绝学习和巩固过程。然而,我们必须承认，在现实生活中，这些因素不是孤立地运作的，他们手牵手。在这一章中,有关性别和应激激素对灭绝过程和暴露疗法的相互作用的现有证据将被整合和讨论。首先存在的提示是，这些因素结合在一起的关键目标是灭绝学习和巩固过程，呼吁对确切的潜在机制进行更详细的研究。除了大样本量的实验，我们必须致力于全世界实验室的共同努力，以便能够确定与改进相关的因素的关键组合，但也损害了灭绝过程和暴露疗法的成功。我们预计，进一步相关因素的启示将不仅限于性和压力荷尔蒙之间的相互作用，还将包括睡眠和运动等因素。从长远来看,发现最重要的相互作用的影响，将给我们提供关键的提示，以实现不同的治疗方案，在意义上的个性化医疗方法。
Effects of a specific factor on fear extinction or exposure therapy have revealed promising results, for example how sex or stress hormones exert the capability to critically change extinction learning and consolidation processes. However, we must acknowledge that in real life these factors do not operate in isolation, they go hand in hand. In this chapter, the available evidence regarding interactions of sex and stress hormones on extinction processes and exposure therapy will be integrated and discussed. First hints exist that these factors in combination critically target extinction learning and consolidation processes, calling for more detailed research on the exact underlying mechanisms. In addition to experiments with high sample sizes, we must aim for a collaborative effort of laboratories across the whole world to be able to identify critical combinations of factors associated with improved, but also impaired extinction processes and exposure therapy success. We expect that the revelation of further relevant factors will not only be limited to the interplay between sex and stress hormones but will include factors such as sleep and exercise as well. In the long run, uncovering the most important interaction effects will give us critical hints for differential treatment options to be realized in the sense of a personalized medicine approach.
