目的:本研究的目的是检查通过降低秩回归(RRR)模型得出的膳食模式之间的关联,该模型反映了新型生物标志物(三甲胺N-氧化物,β-丙氨酸,色氨酸指数,和维生素B6)有中风风险。
结果:我们基于一项基于社区的队列研究“中国心血管发病率和死亡率前瞻性随访研究(PFS-CMMC)”进行分析。因子负荷是通过RRR计算的,使用通过经过验证的食物频率问卷收集的11个食物组,以及基于其嵌套病例对照数据的四个反应变量(393例中风与393个匹配的控件)。通过将因子负荷应用于整个队列中的食物组来得出饮食模式得分(n=15,518)。使用Cox比例风险模型评估饮食模式与卒中风险的相关性。膳食模式的特点是红肉和家禽的摄入量较高,但新鲜蔬菜的摄入量较低,新鲜水果,并确定了鱼类/海产品进行进一步分析。最高风险比(HR)与总卒中最低四分位数为1.55[95%置信区间(CI):1.18-2.03,P趋势=0.001],非缺血性卒中2.96[95%CI:1.53-5.71,P趋势<0.001],在性别调整后,年龄,教育程度,目前吸烟,当前饮酒,身体质量指数,总能量摄入,中风家族史,高血压,糖尿病,高脂血症,和估计的肾小球滤过率。
结论:我们的研究结果强调了限制肉类摄入量和增加新鲜蔬菜摄入量的重要性。水果,和鱼类/海产品在预防中国成年人中风中的作用。
OBJECTIVE: The aim of this study was to examine the associations of dietary patterns derived by reduced-rank regression (RRR) model reflecting variation in novel biomarkers (trimethylamine N-oxide, β-alanine, tryptophan index, and vitamin B6) with stroke risk.
RESULTS: We performed analyses based on a community-based cohort study \"the Prospective Follow-up Study on Cardiovascular Morbidity and Mortality in
China (PFS-CMMC)\". Factor loadings were calculated by RRR using 11 food groups collected via a validated food frequency questionnaire and the four response variables based on its nested case-control data (393 cases of stroke vs. 393 matched controls). Dietary pattern scores were derived by applying the factor loadings to the food groups in the entire cohort (n = 15,518). The associations of dietary pattern with the stroke risk were assessed using Cox proportional hazards models. The dietary pattern characterized with higher intakes of red meat and poultry but lower intakes of fresh vegetables, fresh fruits, and fish/seafoods were identified for further analyses. The hazard ratios (HR) for the highest vs. lowest quartile was 1.55 [95 % confidence interval (CI): 1.18-2.03, P trend = 0.001] for total stroke, 2.96 [95 % CI: 1.53-5.71, P trend <0.001] for non-ischemic stroke, after adjustment for sex, age, educational attainment, current smoking, current drinking, body mass index, total energy intake, family history of stroke, hypertension, diabetes, hyperlipidemia, and estimated glomerular filtration rate.
CONCLUSIONS: Our findings highlight the importance of limited meat intake and increased intakes of fresh vegetables, fruits, and fish/seafoods in the prevention of stroke among Chinese adults.