背景:体重过轻是酒精依赖患者的一个重要症状,然而,很少有研究对中国男性患者的体重过轻进行研究。当前的研究旨在确定患病率,社会人口统计学,中国男性酒精依赖患者体重过轻的临床相关性。
方法:在这项横断面研究中,招募了405名男性酒精依赖住院患者和383名健康男性对照。参与者的人口统计学和临床数据,包括人体测量数据,被收集。我们首先进行了单变量分析,以确定群体之间存在显着差异的七个变量:吸烟行为,住院治疗,酒精消费,脑梗塞,高血压,汉密尔顿抑郁量表(HAMD)评分,阴性症状评定量表(SANS)评分。然后,二元逻辑回归用于评估它们与体重不足的关系,显著性水平为.05。
结果:研究人群体重不足的患病率明显高于对照组(2.99%vs.2.87%;P<.001)。体重过轻的患者吸烟行为和脑梗死的发生率明显较高,以及SANS和HAMD评分高于非体重不足患者。非体重不足患者的每日饮酒量和住院次数较高。此外,Logistic回归分析显示,吸烟行为[优势比(OR)=2.84,95%置信区间(CI)=1.03-7.80,P=.043],脑梗死(OR=5.20,95%CI=1.13~23.85,P=0.036),SANS评分(OR=1.22,95%CI=1.16-1.28,P<.001),HAMD评分(OR=1.06,95%CI=1.02-1.11,P=0.005)与体重过轻相关。
结论:中国样本中超过20%的男性酒精依赖患者体重不足。酒精依赖患者体重不足的一些人口统计学和临床变量独立相关。我们需要关注酒精依赖的吸烟患者,脑梗塞,抑郁症,和更突出的阴性症状。
BACKGROUND: Underweight is a significant symptom in alcohol-dependent patients, yet few studies have examined
underweight in Chinese male patients. The current study aimed to identify the prevalence, sociodemographic, and clinical correlates of
underweight in Chinese male patients with alcohol dependency.
METHODS: In this cross-sectional study, 405 male inpatients with alcohol dependence and 383 healthy male controls were recruited. Participants\' demographic and clinical data, including anthropometric data, were collected. We first conducted univariate analysis to identify seven variables with significant differences between groups: smoking behavior, hospitalization, alcohol consumption, cerebral infarction, hypertension, Hamilton Depression Scale (HAMD) score, and Scale for Assessment of Negative Symptom (SANS) score. Then, binary logistic regression was used to assess their relationship with underweight, with a significance level of .05.
RESULTS: The prevalence of underweight was significantly higher in the study population than in the control group (2.99% vs. 2.87%; P < .001). Patients with underweight had significantly higher rates of smoking behavior and cerebral infarction, as well as higher scores of SANS and HAMD than non-
underweight patients. The non-
underweight patients had higher daily alcohol consumption and times of hospitalization. Furthermore, logistic regression analysis showed that smoking behavior [odds ratio (OR) = 2.84, 95% confidence interval (CI) = 1.03-7.80, P = .043)], cerebral infarction (OR = 5.20, 95% CI = 1.13-23.85, P = .036), SANS score (OR = 1.22, 95% CI = 1.16-1.28, P < .001), and HAMD score (OR = 1.06, 95% CI = 1.02-1.11, P = .005) were associated with underweight.
CONCLUSIONS: More than 20% of male alcohol-dependent patients in a Chinese sample were underweight. Some demographic and clinical variables independent correlates for underweight in alcohol-dependent patients. We need to focus on alcohol-dependent patients with smoking, cerebral infarction, depression, and more prominent negative symptoms.