■母亲肥胖以前与早产风险增加有关;然而,这一观察背后的实际病理生理学仍然未知。颈部长度似乎在超重之间有区别,肥胖和极度肥胖的患者,与正常体重的女性相比。然而,迄今为止,体重指数和宫颈长度之间的实际关联仍然未知.在这次系统审查中,提供积累的证据来帮助建立临床实施和研究观点。
■我们搜索了Medline,Scopus,Cochrane中央受控试验中央登记册,谷歌学者,和Clinicaltrials.gov数据库从成立到2023年2月。包括对怀孕期间接受超声评估宫颈长度的妇女的观察性研究,当有关于他们体重指数的数据时。用RStudio进行统计学荟萃分析。采用纽卡斯尔-渥太华质量评估量表(NOS)对纳入研究的质量进行评估。
■总的来说,20项研究纳入本系统综述,12项纳入荟萃分析。与体重正常的女性相比,体重不足的女性与CL<15mm或<30mm的风险增加无关,且她们的平均CL具有可比性(MD-1.51;95%CI-3.07,0.05).与正常体重的女性相比,超重女性的宫颈长度更长(MD1.87;95%CI0.52,3.23),并且CL<30mm的风险较低(OR0.65;95%CI0.47,0.90)。
■有必要进一步研究孕妇的BMI是否与宫颈长度有关,大,精心设计,与对照组相匹配的前瞻性队列研究。
UNASSIGNED: Maternal obesity has been previously linked to increased risk of preterm birth; however, the actual pathophysiology behind this observation remains unknown. Cervical length seems to differentiate among overweight, obese and extremely obese patients, compared to normal weight women. However, to date the actual association between body mass index and cervical length remains unknown. In this systematic
review, accumulated evidence is presented to help establish clinical implementations and research perspectives.
UNASSIGNED: We searched Medline, Scopus, the Cochrane Central Register of Controlled Trials CENTRAL, Google Scholar, and Clinicaltrials.gov databases from inception till February 2023. Observational studies that reported on women undergone ultrasound assessment of their cervical length during pregnancy were included, when there was data regarding their body mass index. Statistical meta-analysis was performed with RStudio. The quality of the included studies was assessed using the Newcastle-Ottawa Quality Assessment Scale (NOS).
UNASSIGNED: Overall, 20 studies were included in this systematic
review and 12 in the meta-analysis. Compared to women with normal weight,
underweight women were not associated with increased risk of CL < 15 mm or < 30 mm and their mean CL was comparable (MD -1.51; 95% CI -3.07, 0.05). Overweight women were found to have greater cervical length compared to women with normal weight (MD 1.87; 95% CI 0.52, 3.23) and had a lower risk of CL < 30 mm (OR 0.65; 95% CI 0.47, 0.90).
UNASSIGNED: Further research into whether BMI is associated with cervical length in pregnant women is deemed necessary, with large, well-designed, prospective cohort studies with matched control group.