1991年苏维埃社会主义共和国联盟(苏联)解体后,前苏联(FSU)国家的跨境流动性增加。此外,贩毒和注射毒品的使用开始增加,导致血源性感染在FSU国家内部和之间的传播和传播。为了检查血源性感染在该地区的传播,我们分析了两种血液传播病毒的公开序列的系统发育关系,丙型肝炎病毒(HCV)和人类免疫缺陷病毒(HIV),来自FSU国家。
我们分析了来自HCV基因型1b和3a的614和295个NS5B序列,分别,来自9个FSU国家。来自FSU的13个国家,我们分析了347个HIVgag和1282个HIVenv序列.为了检查传播网络和感染的起源,分别,进行了系统发育和贝叶斯分析。
我们的分析显示HCV和HIV序列混合,表明这些病毒在FSU国家内部和之间的传播。我们显示了三个主要人群参与传播:注射吸毒者,异性恋,和跨境移民。
这项研究强调了在FSU国家中,需要将减少伤害的工作重点放在控制上述高危人群中血液传播感染的传播上。
Following the collapse of the Union of Soviet Socialist Republic (
USSR) in 1991, trans-border mobility increased within the former Soviet Union (FSU) countries. In addition, drug-trafficking and injection drug use began to rise, leading to the propagation and transmission of blood-borne infections within and across the FSU countries. To examine the transmission of blood-borne infections within this region, we analyzed the phylogenetic relationship of publically available sequences of two blood-borne viruses, hepatitis C virus (HCV) and human immunodeficiency virus (HIV), from FSU countries.
We analysed 614 and 295 NS5B sequences from HCV genotypes 1b and 3a, respectively, from 9 FSU countries. From 13 FSU countries, we analysed 347 HIV gag and 1282 HIV env sequences. To examine transmission networks and the origins of infection, respectively, phylogenetic and Bayesian analyses were performed.
Our analysis shows intermixing of HCV and HIV sequences, suggesting transmission of these viruses both within and across FSU countries. We show involvement of three major populations in transmission: injection drug user, heterosexual, and trans-border migrants.
This study highlights the need to focus harm reduction efforts toward controlling transmission of blood-borne infections among the abovementioned high-risk populations in the FSU countries.