背景:舌下辅助免疫疗法(SLIT)在纠正由螨引起的变应性鼻炎(AR)患者的结构问题中的疗效尚未研究。
方法:这项非随机对照研究招募了患有AR(由螨引起)并并发间隔偏离和下鼻甲肥大的患者,在台湾的一家三级医院。对所有患者进行SMP作为手术干预。然后将患者分为两组:对照组,只接受了手术,和实验组,接受SLIT作为辅助治疗。分析人口统计学数据和鼻炎控制评估测试(RCAT)结果。
结果:本研究共纳入96例患者(SMP+SLIT组,n=52;仅SMP组,n=44)。手术前和手术后一个月,两组之间的任何变量均无显着差异。然而,在第三个月和第六个月的评估中,与仅SMP组相比,SMP+SLIT组RCAT总分显着改善(28.6±1.56vs.24.5±3.66,p<0.001;27.1±2.87vs.19.9±5.56,p<0.001)。此外,在第3个月和第6个月评估时,在SMP+SLIT组中观察到所有RCAT亚类的控制显著更好.
结论:SLIT可作为AR患者SMP后的理想辅助治疗。
方法:三级喉镜,2024.
BACKGROUND: The efficacy of adjuvant sublingual immunotherapy (SLIT) in correcting structural problems in patients with allergic rhinitis (AR) caused by mite who have undergone septomeatoplasty (SMP) has not been studied.
METHODS: This non-randomized controlled study recruited patients with AR (caused by mite) and concurrent septal deviation and inferior turbinate hypertrophy, at a tertiary hospital in Taiwan. SMP was performed on all patients as a surgical intervention. The patients were then divided into two groups: the control group, which underwent surgery only, and the experimental group, which received SLIT as an adjuvant treatment. Demographic data and rhinitis control assessment test (RCAT) results were analyzed.
RESULTS: A total of 96 patients were enrolled in the study (SMP + SLIT group, n = 52; SMP only group, n = 44). No significant differences were observed in any of the variables between the two groups before and one month after surgery. However, during evaluations at the third and sixth month, the SMP + SLIT group showed significant improvement in the total RCAT scores compared to the SMP only group (28.6 ± 1.56 vs. 24.5 ± 3.66, p < 0.001; 27.1 ± 2.87 vs. 19.9 ± 5.56, p < 0.001). In addition, significantly better control of all RCAT sub-categories was observed in the SMP + SLIT group at the third and sixth month evaluations.
CONCLUSIONS: SLIT may serve as an ideal adjuvant therapy after SMP in patients with AR.
METHODS: 3 Laryngoscope, 134:3073-3079, 2024.